Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular normalization

Wang, Kai; Chen, Qinhua; Liu, Nanxin; Zhang, Jie; Pan, Xiaoyan

doi:10.1016/j.drudis.2021.07.024

Cited by 27 publications

(16 citation statements)

References 66 publications

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“…Increasing clinical evidences show that anti-angiogenesis therapy enhances the efficacy of chemotherapy in solid tumors [ 32 , 33 ]. In this study, we found that PELP1 suppression can inhibit angiogenesis in CRC.…”

Section: Resultsmentioning

confidence: 99%

Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer

Zhu

Wang

et al. 2022

Cancers

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Abnormal angiogenesis is one of the important hallmarks of colorectal cancer as well as other solid tumors. Optimally, anti-angiogenesis therapy could restrain malignant angiogenesis to control tumor expansion. PELP1 is as a scaffolding oncogenic protein in a variety of cancer types, but its involvement in angiogenesis is unknown. In this study, PELP1 was found to be abnormally upregulated and highly coincidental with increased MVD in CRC. Further, treatment with conditioned medium (CM) from PELP1 knockdown CRC cells remarkably arrested the function of human umbilical vein endothelial cells (HUVECs) compared to those treated with CM from wildtype cells. Mechanistically, the STAT3/VEGFA axis was found to mediate PELP1-induced angiogenetic phenotypes of HUVECs. Moreover, suppression of PELP1 reduced tumor growth and angiogenesis in vivo accompanied by inactivation of STAT3/VEGFA pathway. Notably, in vivo, PELP1 suppression could enhance the efficacy of chemotherapy, which is caused by the normalization of vessels. Collectively, our findings provide a preclinical proof of concept that targeting PELP1 to decrease STAT3/VEGFA-mediated angiogenesis and improve responses to chemotherapy due to normalization of vessels. Given the newly defined contribution to angiogenesis of PELP1, targeting PELP1 may be a potentially ideal therapeutic strategy for CRC as well as other solid tumors.

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Section: Resultsmentioning

confidence: 99%

Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer

Zhu

Wang

et al. 2022

Cancers

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“…A limitation of anti-VEGF therapeutic strategies is the need of using them in combination with other therapies. A possible explanation is that anti-VEFG drugs can "normalize" the aberrant tumor vasculature, so that it would become more functional, allowing "traditional" chemotherapy to reach the tumor and function more effectively [125,126]. In this line, the use of antiangiogenic strategies is currently being explored to increase the efficacy of immunotherapy, an important therapeutic modality that is revolutionizing cancer treatment [127][128][129].…”

Section: Use Of Inhibitors Of Angiogenesis In Cancermentioning

confidence: 99%

Angioprevention of Urologic Cancers by Plant-Derived Foods

et al. 2022

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The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to decrease the chances to develop cancer, epidemiological evidence support the role of certain plant-derived foods in the prevention of urologic cancer. In many cases, these plants are rich in antiangiogenic phytochemicals, which could be responsible for their protective or angiopreventive properties. Angiogenesis inhibition may contribute to slow down the progression of the tumor at very different stages and, for this reason, angiopreventive strategies could be implemented at different levels of chemoprevention, depending on the targeted population. In this review, epidemiological evidence supporting the role of certain plant-derived foods in urologic cancer prevention are presented, with particular emphasis on their content in bioactive phytochemicals that could be used in the angioprevention of cancer.

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“…The tumor vasculature is disorganized and immature, with loose connections and low pericyte coverage. In addition, this vascular system does not provide a continuous blood supply to the tumor tissue, thus increasing the distant metastasis of tumor cells and decreasing the tropism of CTLs to TME (48)(49)(50)(51). The cGAS-STING pathway-induced activation of Type-1 interferon upregulates the vascular normalization genes such as Cdh5, Angpt1, Pdgfrb, Mcam, and Col4a.…”

Section: Activation Of the Cgas-sting Pathway Promotes The Traffickin...mentioning

confidence: 99%

Cancer immunotherapy strategies that target the cGAS-STING pathway

et al. 2022

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Activation of the cGAS-STING pathway by cytoplasmic DNA induces the production of Type-1 interferons. Recent advances in research suggest that the cGAS-STING pathway is involved in different parts of the cancer-immunity cycle (CIC) to promote or suppress antitumor immune responses. Combination therapy of STING agonists has made certain progress in preclinical as well as clinical trials, but the selection of combination therapy regimens remains a challenge. In this review, we summarize the role of the cGAS-STING in all aspects of CIC, and focus on the combination immunotherapy strategies of STING agonists and current unsolved challenges.

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Recent advances in, and challenges of, anti-angiogenesis agents for tumor chemotherapy based on vascular normalization

Cited by 27 publications

References 66 publications

Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer

Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer

Angioprevention of Urologic Cancers by Plant-Derived Foods

Cancer immunotherapy strategies that target the cGAS-STING pathway

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