Recent advances in age-related meibomian gland dysfunction (ARMGD)

Moreno, Isabel; Verma, Sudhir; Gesteira, Tarsis Ferreira; Coulson- Thomas, Vivien J.

doi:10.1016/j.jtos.2023.11.003

Cited by 2 publications

(2 citation statements)

References 107 publications

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“…Meibomian gland dysfunction (MGD) may be determined by observing the morphological structure of the glands and assessing their appearance and function on the eyelid margin, where the orifices of the glands are located and the meibum is secreted [12]. Signs of EDE and ADDE may overlap in the most severe cases of DED, which are highly prevalent in women and those of advanced age [13][14][15]. The meibomian glands suffer from various age-related changes, including meibomian gland atrophy and dropout and decreased acinar cell proliferation [13,15].…”

Section: Introductionmentioning

confidence: 99%

“…Signs of EDE and ADDE may overlap in the most severe cases of DED, which are highly prevalent in women and those of advanced age [13][14][15]. The meibomian glands suffer from various age-related changes, including meibomian gland atrophy and dropout and decreased acinar cell proliferation [13,15]. Moreover, a reduction in tear production seems to occur later in life, close to 50 years old [14].…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Pena-Verdeal,

Garcia-Queiruga,

Sabucedo-Villamarin

et al. 2024

JCM

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(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for the detection of the presence of aqueous deficient dry eye (ADDE). (2) Methods: A sample of 260 participants with dry eye complaints underwent ocular surface examinations thorough diagnostic assessments based on the Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE and ADDE based on TMH. Statistical analyses to determine the optimal TMH|OD-OS| cut-off value in a randomly selected study group (200 participants) were performed, while a separate validation analysis of the cut-off value obtained in a random cross-validation group (60 participants) was also performed. (3) Results: The significant diagnostic capability of TMH|OD-OS| (area under the curve = 0.719 ± 0.036, p < 0.001) was found. The identified cut-off value of 0.033 mm demonstrated reliable specificity (77.6%) and moderate sensitivity (59.1%). Cross-validation confirmed the cut-off value’s association with the TFOS DEWS II diagnostic criterion (Cramer’s V = 0.354, p = 0.006). (4) Conclusions: The present study provides evidence for the diagnostic potential of TMH|OD-OS| in identifying ADDE. The identified cut-off value enhances the specificity and offers moderate sensitivity, providing an objective tool for clinical decision making.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Pena-Verdeal,

Garcia-Queiruga,

Sabucedo-Villamarin

et al. 2024

JCM

View full text Add to dashboard Cite

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Identification of Meibomian gland stem cell populations and mechanisms of aging

Zhu,

Xu,

Portal

et al. 2024

Preprint

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SummaryMeibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related Meibomian gland shrinkage may result in part from stem cell exhaustion and is associated with evaporative dry eye disease, a common condition lacking effective treatment. The identities and niche of Meibomian gland stem cells and the signals controlling their activity are poorly defined. Using snRNA-seq, in vivo lineage tracing, ex vivo live imaging, and genetic studies in mice, we identified markers for stem cell populations that maintain distinct regions of the gland and uncovered Hh signaling as a key regulator of stem cell proliferation. Consistent with this, human Meibomian gland carcinoma exhibited increased Hh signaling. Aged glands displayed decreased Hh and EGF signaling, deficient innervation, and loss of collagen I in niche fibroblasts, indicating that alterations in both glandular epithelial cells and their surrounding microenvironment contribute to age-related degeneration. These findings suggest new approaches to treat aging-associated Meibomian gland loss.

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Recent advances in age-related meibomian gland dysfunction (ARMGD)

Cited by 2 publications

References 107 publications

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

A Comprehensive Study on Tear Meniscus Height Inter-Eye Differences in Aqueous Deficient Dry Eye Diagnosis

Identification of Meibomian gland stem cell populations and mechanisms of aging

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