Recent advances in activatable fluorescence imaging probes for tumor imaging

Zhao, Jing Hua; Jin, Guorui; Weng, Guo-jun; Li, Jianjun; Zhu, Jian; Zhao, Jun-Wu

doi:10.1016/j.drudis.2017.04.006

Cited by 55 publications

(27 citation statements)

References 57 publications

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“…Since sensitivity and selectivity are vital for the early detection of cancer metastases, researchers have developed probes that react with molecules that have major functional roles in pathology—mainly in tumor growth. Such materials have been developed for other imaging modalities such as fluorescence imaging [ 162 ], PET, MRI, computed tomography (CT), and echography [ 163 ] and tested in vivo on tumor-bearing mice. PAI nanoprobes can detect cancer-associated growth on a molecular level and help clinicians administer precise dosage amounts to cancer patients, thus decreasing the adverse side effects of conventional chemotherapy.…”

Section: Contrast Agents For In Vivo Testingmentioning

confidence: 99%

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

et al. 2022

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The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current state-of-the-art oncology imaging techniques have decreased mortality rates, patients still face a diminished quality of life due to treatment. Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. This review summarizes in vivo studies that utilize contrast agents within the field of photoacoustic imaging—a relatively new imaging modality—for tumor detection, with a special focus on imaging and transducer parameters. This paper also details the different types of contrast agents used in this novel diagnostic field, i.e., organic-based, metal/inorganic-based, and dye-based contrast agents. We conclude this review by discussing the challenges and future direction of photoacoustic imaging.

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Section: Contrast Agents For In Vivo Testingmentioning

confidence: 99%

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

et al. 2022

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“…Optical microscopy and more specifically fluorescence microscopy is a crucial tool used to investigate cells, living tissues and small organisms [205,206,207]. While it is compatible with live-cell imaging, the optical diffraction limit of simple imaging tools prevents the structure of objects that are smaller than around the optical wavelength from being resolved [208]: two light sources such as fluorophores that are separated by less than a few hundred nanometres will be indistinguishable.…”

Section: Quantum-enabled Bioimagingmentioning

confidence: 99%

Quantum Biotechnology

Mauranyapin¹,

Terrason²,

Bowen³

2021

Preprint

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Quantum technologies leverage the laws of quantum physics to achieve performance advantages in applications ranging from computing to communications and sensing. They have been proposed to have a range of applications in biological science. This includes better microscopes and biosensors, improved simulations of molecular processes, and new capabilities to control the behaviour of biomolecules and chemical reactions. Quantum effects are also predicted, with much debate, to have functional benefits in biology, for instance, allowing more efficient energy transport and improving the rate of enzyme catalysis. Conversely, the robustness of biological systems to disorder from their environment has led to proposals to use them as components within quantum technologies, for instance as light sources for quantum communication systems. Together, this breadth of prospective applications at the interface of quantum and biological science suggests that quantum physics will play an important role in stimulating future biotechnological advances. This review aims to provide an overview of this emerging field of quantum biotechnology, introducing current capabilities, future prospects, and potential areas of impact. The review is written to be accessible to the non-expert and focuses on the four key areas of quantum-enabled sensing, quantum-enabled imaging, quantum biomolecular control, and quantum effects in biology.

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“…These nanoparticle formulations demonstrate remarkable potentials in the imaging by a targeting molecule mediation and in the photodynamic therapy (PDT) by generating ROS under light irradiation. 48,49 In the present study, dsRNA mPEI nanoparticles are developed for gene therapy by inhibiting the growth, invasion and migration of TNBC cells through knocking-down Fra-1 and its relevant genes. Albeit the differences in the action mechanism and the components of nanoparticles, the results from the present study reveal a promising new nanoparticle formulation to inhibit the growth and to overcome the invasiveness of the TNBC cancer.…”

Section: Inhibition Effect On the Invasiveness Of Tnbc Cellsmentioning

confidence: 99%