Recent Advances for the Synthesis of N‐Unsubstituted Pyrroles

Abstract

Pyrroles are an interesting class of heterocyclic compounds due to their widespread use both in medical chemistry and in the chemistry of new materials. Search and development of new effective methods for the synthesis of the pyrrole ring is an urgent task. Along with this, the systematization of already known synthesis methods is an equally important task. Herein, we focused on the results of the synthesis of NH‐pyrroles that have been obtained since 2015.

Synthesis of N‐ureido Pyrrole Derivatives Through Gold‐Catalysed Reaction: Solvent and Catalyst Effect

“…There are many published methods for the synthesis of pyrroles and substituted pyrroles. [8][9][10][11][12][13] One of these methods is the synthesis of pyrrole derivatives by metal-catalyzed cyclization of unconjugated ynone starting compounds. Unconjugated ynones are compounds that contain at least one carbon between the carbonyl group and the alkyne group.…”

“…Pyrrole‐containing organic structures are heterocyclic compounds used in natural products, [1–3] pharmaceutical industry, [4,5] electrical/electronic applications [6,7] and many other fields. There are many published methods for the synthesis of pyrroles and substituted pyrroles [8–13] . One of these methods is the synthesis of pyrrole derivatives by metal‐catalyzed cyclization of unconjugated ynone starting compounds.…”

Synthesis and photophysical properties of 1,7-aroyl BODIPYs: an experimental and theoretical study

“…Methods for the synthesis of such compounds are well developed and do not cause synthetic difficulties. 9 There are two diverse synthetic approaches towards this ligand, both adapted from porphyrin chemistry. 1 c The first approach starts with an acid-catalyzed condensation of a pyrrole with an aldehyde forming a dipyrromethane.…”