Recent advances and perspectives of aggregation-induced emission as an emerging platform for detection and bioimaging

Khan, Imran Mahmood; Niazi, Sobia; Khan, Muhammad Kashif; Pasha, Imran; Mohsin, Ali; Haider, Junaid; Iqbal, Muhammad Waheed; Rehman, Abdur; Yue, Lin; Wang, Zhouping

doi:10.1016/j.trac.2019.115637

Cited by 68 publications

(38 citation statements)

References 161 publications

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“…In this respect, alternate nontoxic fluorescent materials with other required properties are desired. 237 − 244 AIEgens offer unique optical properties with less toxicity, allowing them to be used as promising fluorescent probes for a highly sensitive and selective detection of pathogens and turn-on fluorescent sensing and imaging. Also, in their aggregate form, AIE-based supramolecular nanostructure forms are proven to be efficient for a light-up diagnosis of a pathogen as well as an image-guided photodynamic inactivation (PDI) therapy for a pathogenic infection.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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The COVID-19 outbreak has exposed the world’s preparation to fight against unknown/unexplored infectious and life-threatening pathogens. The unavailability of vaccines, slow or sometimes unreliable real-time virus/bacteria detection techniques, insufficient personal protective equipment (PPE), and a shortage of ventilators and many other transportation equipments have further raised serious concerns. Material research has been playing a pivotal role in developing antimicrobial agents for water treatment and photodynamic therapy, fast and ultrasensitive biosensors for virus/biomarkers detection, as well as for relevant biomedical and environmental applications. It has been noticed that these research efforts nowadays primarily focus on the nanomaterials-based platforms owing to their simplicity, reliability, and feasibility. In particular, nanostructured fluorescent materials have shown key potential due to their fascinating optical and unique properties at the nanoscale to combat against a COVID-19 kind of pandemic. Keeping these points in mind, this review attempts to give a perspective on the four key fluorescent materials of different families, including carbon dots, metal nanoclusters, aggregation-induced-emission luminogens, and MXenes, which possess great potential for the development of ultrasensitive biosensors and infective antimicrobial agents to fight against various infections/diseases. Particular emphasis has been given to the biomedical and environmental applications that are linked directly or indirectly to the efforts in combating COVID-19 pandemics. This review also aims to raise the awareness of researchers and scientists across the world to utilize such powerful materials in tackling similar pandemics in future.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Saraf

Yaraki

Prateek

et al. 2021

ACS Appl. Nano Mater.

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“…[ 43 ] In addition, the size of MC‐TPE micelles underwent decrease to reduce the distance between TPE moieties to restrict intramolecular rotation and vibration at high temperature, so that the fluorescent intensity should show enhancement due to AIE effect. [ 47,48 ] However, the fluorescent intensity of MC‐TPE exhibited decrease with temperature increasing. It was because the decreased intensity caused by heating was much more than that of the increased intensity caused by AIE effect.…”

Section: Figurementioning

confidence: 99%

Synthesis and Fluorescent Thermoresponsive Properties of Tetraphenylethylene‐Labeled Methylcellulose

Wang

Deng

et al. 2020

Macromol. Rapid Commun.

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Functional polymer, especially the one based on renewable and sustainable materials, has attracted increasing attention to satisfy the growing demand for the design of stimuli‐responsive devices. Methylcellulose (MC) is a water‐soluble derivative of cellulose, which has been widely used in many fields for its biocompatibility and biological inertness. In this work, MC is labeled by tetraphenylethylene (TPE) via azide–alkyne click reaction to obtain a fluorescent cellulose‐based derivative of MC‐TPE. The degree of substitution of MC‐TPE is determined to be 0.074, which can be self‐assembled into micelles in water with the size of 42 ± 6 nm. MC‐TPE shows thermoresponsivity and thermoreversibility in size, transmittance, and fluorescence, enabling it to work as a fluorescent thermosensor. Moreover, MC‐TPE exhibits nontoxicity and biocompatibility, allowing its application in MCF‐7 cell imaging. Therefore, this newly functional natural polymer shows promising potentials in the fields of sensing and bioimaging.

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“…Furthermore, they can be applied as biosensors for the detection of amino acids and proteins or for monitoring conformational changes of DNA or proteins [4,12] as well as bioimaging [13] . Along those lines, AIEs can also serve as a biomarker for diagnosing diseases as recently demonstrated by Lou and Xia for a real‐time quantitative light detection of telomerase in the urine of bladder cancer patients with a cationic AIE tetraphenylethene derivative [14] …”

Section: Introductionmentioning

confidence: 99%

“…[13] Along those lines, AIEs can also serve as a biomarker for diagnosing diseases as recently demonstrated by Lou and Xia for a real-time quantitative light detection of telomerase in the urine of bladder cancer patients with a cationic AIE tetraphenylethene derivative. [14] When developing such novel biomarkers or biosensors, the luminophore has to be modified in a way that allows for strong and ideally specific binding to the target molecule. Usually this is achieved either by bioconjugation for example of a peptide or antibody, or by introducing non-natural recognition motifs such as charged groups or supramolecular binding motifs.…”

Section: Introductionmentioning

confidence: 99%

Take your Positions and Shine: Effects of Positioning Aggregation‐Induced Emission Luminophores within Sequence‐Defined Macromolecules

Pasch

Killa

Junghans

et al. 2021

Chemistry A European J

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A luminophore with aggregation‐induced emission (AIE) is employed for the conjugation onto supramolecular ligands to allow for detection of ligand binding. Supramolecular ligands are based on the combination of sequence‐defined oligo(amidoamine) scaffolds and guanidiniocarbonyl‐pyrrole (GCP) as binding motif. We hypothesize that AIE properties are strongly affected by positioning of the luminophore within the ligand scaffold. Therefore, we systematically investigate the effects placing the AIE luminophore at different positions within the overall construct, for example, in the main or side chain of the olig(amidoamine). Indeed, we can show that the position within the ligand structure strongly affects AIE, both for the ligand itself as well as when applying the ligand for the detection of different biological and synthetic polyanions.

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Recent advances and perspectives of aggregation-induced emission as an emerging platform for detection and bioimaging

Cited by 68 publications

References 161 publications

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Insights and Perspectives Regarding Nanostructured Fluorescent Materials toward Tackling COVID-19 and Future Pandemics

Synthesis and Fluorescent Thermoresponsive Properties of Tetraphenylethylene‐Labeled Methylcellulose

Take your Positions and Shine: Effects of Positioning Aggregation‐Induced Emission Luminophores within Sequence‐Defined Macromolecules

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