Recent advances and emerging treatments

Enoch, Stuart; Grey, Joseph E; Harding, Keith

doi:10.1136/bmj.332.7547.962

Cited by 126 publications

(118 citation statements)

References 3 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…Granulocyte-macrophage colony-stimulating factor & Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a growth factor that mediates epidermal cell proliferation [50]. …”

Section: Growth Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Venous Leg Ulcerations: A Treatment Update

Farah

Davis

2010

Curr Treat Options Cardio Med

View full text Add to dashboard Cite

Selecting the appropriate treatment for venous leg ulcerations is essential for optimal wound healing and patient quality of life. Compression therapy remains the mainstay of treatment for these wounds. Compression methods should be carefully selected and tailored for compatibility with patients' daily life. Pain management should not be neglected. When response to compression therapy is limited, adjuvant therapy such as medication, débridement, or surgical procedures should be considered on an individual basis.

show abstract

“…Granulocyte-macrophage colony-stimulating factor & Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a growth factor that mediates epidermal cell proliferation [50]. …”

Section: Growth Factorsmentioning

confidence: 99%

“…Topical recombinant human GM-CSF has been demonstrated to enhance healing of venous leg ulcers[50]. Recent research investigating the clinical use of GM-CSF is limited.…”

mentioning

confidence: 99%

Venous Leg Ulcerations: A Treatment Update

Farah

Davis

2010

Curr Treat Options Cardio Med

View full text Add to dashboard Cite

show abstract

“…Artificial skin substitutes, products of tissue engineering, consist of microengineered, biocompatible, polymer matrix in combination with cellular, and/or extracellular elements such as collagen. 30 An ideal skin substitute should possess the physical characteristics and function of normal skin while healing takes place. However, no perfect or ideal skin substitute yet exists.…”

Section: Modern Skin Engineeringmentioning

confidence: 99%

From Basic Wound Healing to Modern Skin Engineering

Andersson¹,

Nettelblad²,

Kratz

2009

Artificial Organs

View full text Add to dashboard Cite

“…In the context of the increasing number of patients with wounds, defining the role of various wound treatments represents the next challenge. 1) Topical treatment of wounds has many advantages including decreased cost and increased ease of application, compared with the systemic treatments. 2) Increasing studies have demonstrated that faster rates of wound closure could be achieved when an agent was serially delivered over a prolonged period.…”

mentioning

confidence: 99%

Topical Astragaloside IV-Releasing Hydrogel Improves Healing of Skin Wounds <i>in Vivo</i>

Peng

Chen

et al. 2012

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Topical delivery of therapeutic agents at the time of injury to accelerate skin repair and prevent the formation of scars during the wound healing process has received increasing attention and represents a novel regenerative and prophylactic strategy for wound treatment. The aim of this study was to invesigate, for the first time, the influence of topical astragaloside IV-releasing hydrogel on the wound repair and regeneration. Using the sodium alginate-gelatin as a hydrogel vehicle, the astragaloside IV was incorporated into the topical carrier and kept releasing with a sustained manner at the wound site. With the rat skin excision model, regulation of the astragaloside IV hydrogel on the wound repair and regeneration were investigated. It was found that the astragaloside IV hydrogel was effective in the skin wound repair, leading to a significant improvement on the wound closure, collagen synthesis and skin tensile strength recovery. Meanwhile, for the first time, that functions of astragaloside IV hydrogel in activating the skin appendages regeneration and increasing the transforming growth factor-β 1 (TGF-β 1 ) level in serum were shown. Results of this study provided evidence for the alginate-gelatin hydrogel as efficient carrier for the topical delivery of bioactive molecules to the injured site. The astragaloside IV releasing hydrogel was shown a promising therapeutic formulation for wound healing, as well as its regenerative feature and underlying mechanism contribute to the skin regeneration were disclaimed.

show abstract

Recent advances and emerging treatments

Cited by 126 publications

References 3 publications

Venous Leg Ulcerations: A Treatment Update

Venous Leg Ulcerations: A Treatment Update

From Basic Wound Healing to Modern Skin Engineering

Topical Astragaloside IV-Releasing Hydrogel Improves Healing of Skin Wounds <i>in Vivo</i>

Contact Info

Product

Resources

About