Recent advances and biomedical applications of zinc oxide nanoparticles

Rajeshkumar, S.; Lakshmi, T; Naik, Poonam

doi:10.1016/b978-0-08-102579-6.00019-8

Cited by 24 publications

(10 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Titanium dioxide (TiO 2 ) NPs are used for cleaning air and water, and are used in pigments, cosmetics, and skincare products [17]. Zinc oxide (ZnO) NPs are among the most commonly used nanomaterials, with a wide range of applications including biomedical imaging, drug and gene delivery, biosensing, and antibacterial and antifungal applications [18]. Copper oxide (CuO) has a high potential in the development of biosensors [19][20][21], antifouling coatings [22,23], and biocidal [24][25][26] and antitumor agents [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

et al. 2020

View full text Add to dashboard Cite

For the widespread application of nanotechnology in biomedicine, it is necessary to obtain information about their safety. A critical problem is presented by the host immune responses to nanomaterials. It is assumed that the innate immune system plays a crucial role in the interaction of nanomaterials with the host organism. However, there are only fragmented data on the activation of innate immune system factors, such as toll-like receptors (TLRs), by some nanoparticles (NPs). In this study, we investigated TLRs’ activation by clinically relevant and promising NPs, such as Fe3O4, TiO2, ZnO, CuO, Ag2O, and AlOOH. Cytotoxicity and effects on innate immunity factors were studied in THP-1(Tohoku Hospital Pediatrics-1) cell culture. NPs caused an increase of TLR-4 and -6 expression, which was comparable with the LPS-induced level. This suggests that the studied NPs can stimulate the innate immune system response inside the host. The data obtained should be taken into account in future research and to create safe-by-design biomedical nanomaterials.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…ZnO NPs were first used in the rubber industry to provide wear resistance to rubber composites, improve the toughness and intensity of high polymers, and provide anti-aging properties [ 55 , 56 ]. ZnO NPs have also gained attention in biomedical imaging due to their ability to exhibit luminescence [ 57 ]. They have also attracted researchers towards the development of diagnostic tools, as they can also be employed in biosensing applications [ 58 ].…”

Section: Zinc Oxide Nanoparticles (Zno Nps): Potential Candidate For Fighting Cancermentioning

confidence: 99%

“…and provide anti-aging properties [55,56]. ZnO NPs have also gained attention in biomedical imaging due to their ability to exhibit luminescence [57]. They have also attracted researchers towards the development of diagnostic tools, as they can also be employed in biosensing applications [58].…”

Section: Zinc Oxide Nanoparticles (Zno Nps): Potential Candidate For Fighting Cancermentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

193

View full text Add to dashboard Cite

Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.

show abstract

“…The physical and binding properties of the textiles improve when functional polymer matrices such as PMME or PNIPAM are used as dispersing mediums for ZnO nanoparticles. [36,37] ZnO particles nanostructured used on the cotton textile surface with various surfactants to stabilize, homogenize the coating and has enhanced the stability of ZnO Nanoparticles with limited leaching and demonstrated the best antibacterial and antifungal properties against several pathogenic microorganisms with a high reduction of more than 90%. [4]…”

Section: Zinc Oxidementioning

confidence: 99%

Anti-microbial finishing for natural textile fabrics

Kamel

Hassabo

2021

J.Text.color. pol. sci.

View full text Add to dashboard Cite

T HE TEXTILE industries continue to introduce various products to enhance their products' quality to satisfy their clients. Recently Antimicrobial textiles have gained much attention and popularity in the market and day-to-day life. Infestations of microorganisms allow bacteria to transmit disease, and odor occurs in fabrics that come into close contact with the skin. Furthermore, discoloration, tints, and loss of functional characteristics of textiles are the result of microbial damage. Antibacterial finished textile is an important area for medical and hygienic applications also there is an enormous need for non-toxic and eco-friendly antimicrobial agents. The synthetic biocides finish extensively reported were polyhexamethylenebiguanide (PHMB), quaternary ammonium compounds (QACs) and n-halamines, metals (including metal oxides such as ZnO, TiO2, and ag nanoparticles). Whereas, the natural-based biocides chitosan and plant-based extracts. This paper will cover concisely, review of the latest research done at antimicrobial finishing, methods of application, and the impact of these treatments on health and the environment.

show abstract

Recent advances and biomedical applications of zinc oxide nanoparticles

Cited by 24 publications

References 74 publications

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anti-microbial finishing for natural textile fabrics

Contact Info

Product

Resources

About