Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Wu, Jiangchao; Shi, Juan; Yin, Xianghong; Tang, Jianghui; Zhang, Junlei; Wang, Xun; Ji, Yongtao; Zhao, Yongtao; Chen, Dong; Sheng, Jianpeng; Bai, Xiangzhi; Liang, Tingbo

doi:10.31083/j.fbl2705145

Cited by 13 publications

(13 citation statements)

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“…Alleviating the hypoxic environment of lesions has become an efficient strategy in biomedical treatment. [ 221 ] With the development of nanomedicine, various oxygen‐producing materials produce oxygen through different chemical reactions, and oxygen‐carrying materials release oxygen to improve the anoxic environment. Despite these materials have improved tissue oxygenation and the effect of follow‐up treatment, they both suffer from uncontrolled oxygen production or low oxygen release efficiency.…”

Section: Discussionmentioning

confidence: 99%

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Yang,

Li,

Feng

et al. 2023

Adv Funct Materials

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Oxygen as one of the most critical substances in living organisms has attracted ever‐increasing attention in disease treatment, which is important in regulating metabolic activities. However, the hypoxia arising from disease is a prevalent problem, leading to observably reduced therapeutic effectiveness in photodynamic therapy, radiotherapy, sonodynamic therapy, etc. Therefore, the reversion of hypoxia becomes the basis for enhancing the disease treatment. Thanks to the development of nanotechnology, various nanomaterials with oxygen‐production capacity are explored to recover the function of oxygen in tissue, but there are still some limitations. The photosynthetic microorganisms (PSMs) are extensively applied for improving hypoxia in diseases due to their highly efficient photocatalytic oxygen production efficacy and desirable biocompatibility. In this review, the up‐to‐date research progress on therapeutic modalities of microbial‐based photosynthetic oxygenation (e.g., cancer treatment, wound healing, and tissue engineering) are summarized and highlighted. In addition, the key issue of biocompatibility/biosafety of microbial‐based treatment that is fundamental to apply in vivo is further emphasized and clarified. Finally, the present critical issues are discussed and the future evolution of microbial‐based treatment based on photosynthetic oxygenation is predicted, promoting further development and clinical applications.

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Section: Discussionmentioning

confidence: 99%

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Yang,

Li,

Feng

et al. 2023

Adv Funct Materials

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“…[66][67][68] However, free Hb has the disadvantages of poor stability and short blood circulation time, and the Hb tetramer will decompose into dimer and monomer inducing potential toxic and side effects and limiting its O 2 transport into organisms. [11] To reduce the disadvantages of free Hb, researchers modified it through various methods and constructed biocompatible Hb O 2 delivery nanoplatforms. The following two construction strategies are introduced including using Hb surface modification as a drug carrier for direct drug delivery and loading Hb with degradable nanomaterials for drug delivery (Table 3).…”

Section: Hemoglobin Direct O 2 Delivery Nanoplatformmentioning

confidence: 99%

“…Besides, the development of angiogenesis also induced cell metastasis, promoting cancer further by spreading cells from the primary site to distant sites. [9,11] HIFs may prevent tumor cells from differentiating and thus may maintain tumor cells in an undifferentiated "stem cell-like" state. Because malignant progression is a slow and inefficient process, a stem cell state will allow a tumor cell to have sustained self-renewal power to accumulate a battery of genetic and epigenetic changes over a long period to become fully malignant.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Shen

Chen

Zhao

et al. 2023

Adv Healthcare Materials

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Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy including chemotherapy, radiotherapy, photodynamic therapy, etc. In recent years, the construction of hypoxia‐relieving functional nanoplatforms through nanotechnology has become a new strategy to reverse the current situation of tumor microenvironment hypoxia and improve the effectiveness of tumor treatment. Here, the main strategies and recent progress in constructing nanoplatforms are focused on to directly carry oxygen, generate oxygen in situ, inhibit mitochondrial respiration, and enhance blood perfusion to alleviate tumor hypoxia. The advantages and disadvantages of these nanoplatforms are compared. Meanwhile, nanoplatforms based on organic and inorganic substances are also summarized and classified. Through the comprehensive overview, it is hoped that the summary of these nanoplatforms for alleviating hypoxia could provide new enlightenment and prospects for the construction of nanomaterials in this field.

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“…Most of them focus on improving O 2 supply at tumor sites by delivering O 2 directly or substances that can produce O 2 to tumor sites through nanocarriers. [ 5 ] The others try to reduce O 2 consumption by transporting substances that can inhibit metabolism or the antioxidant capacity of tumor cells to tumor sites through nanocarriers. [ 6 ] However, the O 2 supply to tumors of external materials is limited, and the intravenous injection of nanocarriers with unknown pharmacokinetics will increase metabolic risk.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin Derivative with Binary Properties of Photodynamic Therapy and Water‐Dependent Reversible Photoacidity Therapy for Treating Hypoxic Tumor

Kang,

Sun,

Liu

et al. 2024

Adv Healthcare Materials

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Porphyrin photosensitizers are the classic drugs in clinical photodynamic therapy (PDT), but the hypoxia of tumor environment and the rapid oxygen consumption of PDT severely weaken their therapeutic effect. A recently reported water‐dependent reversible photoacidity therapy (W‐RPAT) is O2‐independence, providing a solution for the treatment of hypoxic tumors. In this work, TPP‐O‐PEG5, a porphyrin derivative with binary properties of PDT and W‐RPAT, is designed and synthesized for the first time. The nanoparticles (NPs) of TPP‐O‐PEG5 encapsulated with DSPE‐mPEG2000, an amphiphilic polymer approved by Food and Drug Administration, can simultaneously produce reactive oxygen species and H+ under irradiation of a 660 nm laser, and revert the H+ back under darkness, presenting strong phototoxicity to multiple tumor cell lines with no obvious difference between the IC50 values tested under normoxic (≈20% O2) and hypoxic (<0.5% O2) conditions. Excitingly, in vivo experiments show that the therapeutic effect of TPP‐O‐PEG5 NPs on large hypoxic tumors is better than that of NPe6, a clinical porphin PDT drug. This work provides a novel strategy for porphyrin photosensitizers to break through the limitation of hypoxic environment, and significantly improve the phototherapeutic effect on hypoxic tumors.

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Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Cited by 13 publications

References 0 publications

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Porphyrin Derivative with Binary Properties of Photodynamic Therapy and Water‐Dependent Reversible Photoacidity Therapy for Treating Hypoxic Tumor

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