Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance

Rahman, Md. Mominur; Islam, Md. Rezaul; Akash, Shopnil; Harun-Or-Rashid, Md.; Ray, Tanmay Kumar; Rahaman, Md. Saidur; Islam, Md. Rakibul; Anika, Fazilatunnesa; Hosain, Md. Kawser; Aovi, Farjana Islam; Hemeg, Hassan A.; Rauf, Abdur; Wilairatana, Polrat

doi:10.1016/j.biopha.2022.113305

Cited by 73 publications

(42 citation statements)

References 297 publications

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“…Several investigations have suggested that amyloid protein buildup triggers astrogliosis; nevertheless, activated astrocytes produce an A42-immunopositive substance that changes in concentration across the cerebral cortex in AD brains depending on the severity of the disease. Although the precise method by which A42 material collects inside active astrocytes is unknown, it is thought to be owing to either phagocytosis or endocytosis [194][195][196][197][198][199] (Figures 5 and 6).…”

Section: The Interaction Of Neurons and Glia In Alzheimer'smentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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Based on the diverse physiological influence, the impact of glial cells has become much more evident on neurological illnesses, resulting in the origins of many diseases appearing to be more convoluted than previously happened. Since neurological disorders are often random and unknown, hence the construction of animal models is difficult to build, representing a small fraction of people with a gene mutation. As a result, an immediate necessity is grown to work within in vitro techniques for examining these illnesses. As the scientific community recognizes cell-autonomous contributions to a variety of central nervous system illnesses, therapeutic techniques involving stem cells for treating neurological diseases are gaining traction. The use of stem cells derived from a variety of sources is increasingly being used to replace both neuronal and glial tissue. The brain’s energy demands necessitate the reliance of neurons on glial cells in order for it to function properly. Furthermore, glial cells have diverse functions in terms of regulating their own metabolic activities, as well as collaborating with neurons via secreted signaling or guidance molecules, forming a complex network of neuron-glial connections in health and sickness. Emerging data reveals that metabolic changes in glial cells can cause morphological and functional changes in conjunction with neuronal dysfunction under disease situations, highlighting the importance of neuron-glia interactions in the pathophysiology of neurological illnesses. In this context, it is required to improve our understanding of disease mechanisms and create potential novel therapeutics. According to research, synaptic malfunction is one of the features of various mental diseases, and glial cells are acting as key ingredients not only in synapse formation, growth, and plasticity but also in neuroinflammation and synaptic homeostasis which creates critical physiological capacity in the focused sensory system. The goal of this review article is to elaborate state-of-the-art information on a few glial cell types situated in the central nervous system (CNS) and highlight their role in the onset and progression of neurological disorders.

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Section: The Interaction Of Neurons and Glia In Alzheimer'smentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…It has been shown that controllers of G protein flagging (RGS) proteins provide a vital GAP movement at neuronal G α q/11 subunits. Obstruction of neighbourhood 2-pore region potassium coordinates in cerebellar granule neurons was reconstituted by conveying fanciful G α subunits that are activated by G α i/o-coupled receptors, in this way bypassing endogenous G α q/11 subunits [ 136 , 137 ] .…”

Section: G Protein Signaling Regulators As a Potential Drug Target Fo...mentioning

confidence: 99%

Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation

Rahman

Islam

Mim

et al. 2022

Oxidative Medicine and Cellular Longevity

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G protein-coupled receptors (GPCRs) are intricately involved in the conversion of extracellular feedback to intracellular responses. These specialized receptors possess a crucial role in neurological and psychiatric disorders. Most nonsensory GPCRs are active in almost 90% of complex brain functions. At the time of receptor phosphorylation, a GPCR pathway is essentially activated through a G protein signaling mechanism via a G protein-coupled receptor kinase (GRK). Dopamine, an important neurotransmitter, is primarily involved in the pathophysiology of several CNS disorders; for instance, bipolar disorder, schizophrenia, Parkinson’s disease, and ADHD. Since dopamine, acetylcholine, and glutamate are potent neuropharmacological targets, dopamine itself has potential therapeutic effects in several CNS disorders. GPCRs essentially regulate brain functions by modulating downstream signaling pathways. GPR6, GPR52, and GPR8 are termed orphan GPCRs because they colocalize with dopamine D1 and D2 receptors in neurons of the basal ganglia, either alone or with both receptors. Among the orphan GPCRs, the GPR52 is recognized for being an effective psychiatric receptor. Various antipsychotics like aripiprazole and quetiapine mainly target GPCRs to exert their actions. One of the most important parts of signal transduction is the regulation of G protein signaling (RGS). These substances inhibit the activation of the G protein that initiates GPCR signaling. Developing a combination of RGS inhibitors with GPCR agonists may prove to have promising therapeutic potential. Indeed, several recent studies have suggested that GPCRs represent potentially valuable therapeutic targets for various psychiatric disorders. Molecular biology and genetically modified animal model studies recommend that these enriched GPCRs may also act as potential therapeutic psychoreceptors. Neurotransmitter and neuropeptide GPCR malfunction in the frontal cortex and limbic-related regions, including the hippocampus, hypothalamus, and brainstem, is likely responsible for the complex clinical picture that includes cognitive, perceptual, emotional, and motor symptoms. G protein and GPCR-mediated signaling play a critical role in developing new treatment options for mental health issues, and this study is aimed at offering a thorough picture of that involvement. For patients who are resistant to current therapies, the development of new drugs that target GPCR signaling cascades remains an interesting possibility. These discoveries might serve as a fresh foundation for the creation of creative methods for pharmacologically useful modulation of GPCR function.

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“…It has decreased marginally in men over the past decade (2006–2015) due to all these therapies, and the cancer mortality rate (2007–2016) has also decreased ( Siegel et al, 2019 ). In 2018, cancer caused an expected 9.6 million deaths, and cancer is predicted to be the primary source of death worldwide in the 21st century ( Bray et al, 2018 ; Rahman et al, 2022a ; Rahman et al, 2022b ). Chemoprevention is a somewhat expensive option for treating cancer.…”

Section: Introductionmentioning

confidence: 99%

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

et al. 2022

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Cancer is commonly thought to be the product of irregular cell division. According to the World Health Organization (WHO), cancer is the major cause of death globally. Nature offers an abundant supply of bioactive compounds with high therapeutic efficacy. Anticancer effects have been studied in a variety of phytochemicals found in nature. When Food and Drug Administration (FDA)-approved anticancer drugs are combined with natural compounds, the effectiveness improves. Several agents have already progressed to clinical trials based on these promising results of natural compounds against various cancer forms. Natural compounds prevent cancer cell proliferation, development, and metastasis by inducing cell cycle arrest, activating intrinsic and extrinsic apoptosis pathways, generating reactive oxygen species (ROS), and down-regulating activated signaling pathways. These natural chemicals are known to affect numerous important cellular signaling pathways, such as NF-B, MAPK, Wnt, Notch, Akt, p53, AR, ER, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. As a result, non-toxic “natural drugs” taken from nature’s bounty could be effective for the prevention of tumor progression and/or therapy of human malignancies, either alone or in combination with conventional treatments. Natural compounds have also been shown in preclinical studies to improve the sensitivity of resistant cancers to currently available chemotherapy agents. To summarize, preclinical and clinical findings against cancer indicate that natural-sourced compounds have promising anticancer efficacy. The vital purpose of these studies is to target cellular signaling pathways in cancer by natural compounds.

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Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance

Cited by 73 publications

References 297 publications

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

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