Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration

Taipaleenmäki, Essi; Städler, Brigitte

doi:10.1002/mabi.201900342

Cited by 34 publications

(22 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…260,261 The balance between the hydrophilic and hydrophobic nature of the nanoparticle interface and the digestive system is an important factor responsible for absorption into the body, and hydrophilic coating on the surface of hydrophobic nanoparticles has been widely accepted to increase their absorption. [297][298][299] Maisel et al prepared polystyrene nanoparticles coated with a hydrophilic polymer (PEG) and confirmed their localization to the small intestine in ex vivo studies in Figure 9 The digestive stages after oral administration and the mechanisms of in vivo uptake of surfactant-coated nanoparticles through the small intestine. International Journal of Nanomedicine downloaded from https://www.dovepress.com/ by 44.224.250.200 on 14-Jun-2021 For personal use only.…”

Section: Application Of Food Nanotechnology In the Digestive Systemmentioning

confidence: 86%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

104

View full text Add to dashboard Cite

Surfactants, whose existence has been recognized as early as 2800 BC, have had a long history with the development of human civilization. With the rapid development of nanotechnology in the latter half of the 20th century, breakthroughs in nanomedicine and food nanotechnology using nanoparticles have been remarkable, and new applications have been developed. The technology of surfactant-coated nanoparticles, which provides new functions to nanoparticles for use in the fields of nanomedicine and food nanotechnology, is attracting a lot of attention in the fields of basic research and industry. This review systematically describes these "surfactant-coated nanoparticles" through various sections in order: 1) surfactants, 2) surfactant-coated nanoparticles, application of surfactant-coated nanoparticles to 3) nanomedicine, and 4) food nanotechnology. Furthermore, current progress and problems of the technology using surfactant-coated nanoparticles through recent research reports have been discussed.

show abstract

Section: Application Of Food Nanotechnology In the Digestive Systemmentioning

confidence: 86%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

104

View full text Add to dashboard Cite

show abstract

“…The pharmaceutical industry must be evolving and improving processes for manufacturing accurate and repeatable intranasal dose in the coming years. In this review, we introduced the absorption mechanism, advantages including large absorption surface area, good patient compliance, rapid and high drug permeability, bypassing of hepatic first-pass metabolism, potential direct drug delivery to the brain along the olfactory nerves, and limitations, including rapid drug elimination prompted by mucociliary clearance (5 mm/min for healthy humans), limited administration volume (25-200 ml), and the presence of enzymes that degrade in nasal drug delivery route (Lechanteur et al, 2017(Lechanteur et al, , 2019Chen S. et al, 2020;Lechanteur and Evrard, 2020;Sabir et al, 2020;Taipaleenmaki and Stadler, 2020). Then, we systematically summarized the development of intranasal delivery carriers of antidepressants in clinical studies including nanogels, nanostructured lipid, liposomes nanoparticles, and nanoemulsions/microemulsion.…”

Section: Discussionmentioning

confidence: 99%

Design and Application in Delivery System of Intranasal Antidepressants

Tao

Wang

2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

One of the major reasons why depressed patients fail their treatment course is the existence of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central nervous system (CNS). In recent years, nasal drug delivery has achieved better systemic bioavailability and activity in low doses in antidepressant treatment. In this review, we focused on the latest strategies for delivery carriers (or formation) of intranasal antidepressants. We began this review with an overview of the nasal drug delivery systems, including nasal drug delivery route, absorption mechanism, advantages, and limitations in the nasal drug delivery route. Next, we introduced the development of nasal drug delivery devices, such as powder devices, liquid-based devices, and so on. Finally, intranasal delivery carriers of antidepressants in clinical studies, including nanogels, nanostructured lipid, liposomes nanoparticles, nanoemulsions/microemulsion, were summarized. Moreover, challenges and future perspectives on recent progress of intranasal delivery carriers in antidepressant treatments were discussed.

show abstract

“…Muco-penetration particles are aimed to slip through the mucus with the modification of the particle surface, especially surface charge and viscosity [147]. Due to the overall negative charge of the mucus, formulations with noninteracting polymers, high-charge density net-neutral particles, charge-shifting particles are designed for better penetration of the mucus layer [148,149,154]. On the other hand, the mucoadhesive drug delivery system (MDDS) featuring a longer adhesion time and subsequent penetration through the epithelial membrane is also a desirable formulation design.…”

Section: The Importance Of Polymeric Excipients For Drug Permeability Enhancementmentioning

confidence: 99%

Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery?

et al. 2021

View full text Add to dashboard Cite

Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance the dissolution and bioavailability of poorly water-soluble drugs. The enhancement of ASD in the oral absorption of drugs has been mainly attributed to the high apparent drug solubility during the dissolution. In the last decade, with the implementations of new knowledge and advanced analytical techniques, a drug-rich transient metastable phase was frequently highlighted within the supersaturation stage of the ASD dissolution. The extended drug absorption and bioavailability enhancement may be attributed to the metastability of such drug-rich phases. In this paper, we have reviewed (i) the possible theory behind the formation and stabilization of such metastable drug-rich phases, with a focus on non-classical nucleation; (ii) the additional benefits of the ASD-induced drug-rich phases for bioavailability enhancements. It is envisaged that a greater understanding of the non-classical nucleation theory and its application on the ASD design might accelerate the drug product development process in the future.

show abstract

Recent Advancements in Using Polymers for Intestinal Mucoadhesion and Mucopenetration

Cited by 34 publications

References 89 publications

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Design and Application in Delivery System of Intranasal Antidepressants

Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery?

Contact Info

Product

Resources

About