Recent Advancements in Ultrasound Transducer: From Material Strategies to Biomedical Applications

Li, Jiapu; Ma, Yuchun; Zhang, Tao; Shung, K. Kirk; Zhu, Benpeng

doi:10.34133/2022/9764501

Cited by 40 publications

(16 citation statements)

References 131 publications

(142 reference statements)

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“…Especially, we focused on current device research and application progress of piezoelectric materials in the medical field. Owing to the sensitive piezoelectric or ferroelectric properties, we further summarized the current research on perovskite piezoelectricity, and further designed and proposed its future applications in the field of ultrasound, especially the huge application prospects of ultrasound medicine applications, such as biological and chemical sensors, high-intensity focused ultrasound for medical therapeutics, blood flow rate measurement, and ultrasound imaging [40][41][42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Organic–Inorganic Hybrid Perovskite Materials for Ultrasonic Transducer in Medical Diagnosis

Yang

Zhang

et al. 2022

Crystals

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The ultrasonic transducer is considered the most important component of ultrasound medical instruments, and its key active layer is generally fabricated by piezoelectric materials, such as BaTiO3, Pb (Zn, Ti)O3, PVDF, etc. As the star material, perovskite photovoltaic materials (organic and inorganic halide perovskite materials, such as CH3NH3PbI3, CsPbI3, etc.) have great potential to be widely used in solar cells, LEDs, detectors, and photoelectric and piezoelectric detectors due to their outstanding photoelectric and piezoelectric effects. Herein, we firstly discussed the research progress of commonly used piezoelectric materials and the corresponding piezoelectric effects, the current key scientific status, as well as the current application status in the field of ultrasound medicine. Then, we further explored the current progress of perovskite materials used in piezoelectric-effect devices, and their research difficulties. Finally, we designed an ideal ultrasonic transducer fabricated by perovskite photovoltaic materials and considered the future application prospects of organic and inorganic halide perovskite material in the field of ultrasound.

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Section: Discussionmentioning

confidence: 99%

Organic–Inorganic Hybrid Perovskite Materials for Ultrasonic Transducer in Medical Diagnosis

Yang

Zhang

et al. 2022

Crystals

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“…After half an hour of pre-reading, standard, control, and test samples (15, 30 and 45 mg/kg, respectively) were given intraperitoneally to the label groups, which were then assessed by being placing a over hot plate apparatus. The flinching, paw withdrawal, licking and jumping responses by test animals were recorded post 30, 60 and 90 min of the drugs [ 43 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms

et al. 2022

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The current work examined the pharmacological potential of a selected flavanone derivative 2-hydroxyflavanone as a promising remedy for the treatment and management of pain. The selected flavanone derivative (2-HF) was evaluated for its analgesic and anti-inflammatory potentials following standard pharmacological protocols including hot plate, acetic acid-induced writhing and tail immersion tests. Naloxone and pentylenetetrazol were used to evaluate the potential implication of GABAergic and opioidergic mechanisms. The anti-inflammatory potential of 2-HF was confirmed using carrageenan-, serotonin- and histamine-induced paw edema models as well as a xylene-induced ear edema model. Furthermore, the anti-neuropathic potential of 2-HF was tested using a cisplatin-induced neuropathic pain model. Our sample, at the tested concentrations of 15, 30 and 45 mg kg−1, showed considerable analgesic, anti-inflammatory effects, as well as efficacy against neuropathic pain. Naloxone and pentylenetetrazol at 1 and 15 mg kg−1 antagonized the anti-nociceptive activities of 2-hydroxyflavanone indicating the involvement of opioidergic and GABAergic mechanisms. In the static allodynia model, combination of gabapentin 75 mg kg−1 with 2-HF at 15, 30, 45 mg kg−1 doses exhibited considerable efficacy. In cold allodynia, 2-hydroxyflavanone, at doses of 15, 30 and 45 mg kg−1 and in combination with gabapentin (75 mg kg−1), demonstrated prominent anti-allodynic effects. The paw withdrawal latency was considerably increased in gabapentin + cisplatin treated groups. Moreover, cisplatin + 2-hydroxyflavanone 15, 30, 45 mg kg−1 showed increases in paw withdrawal latency. Likewise, considerable efficacy was observed for 2-hydroxyflavanone in thermal hyperalgesia and dynamic allodynia models. Our findings suggest that 2-hydroxyflavanone is a potential remedy for pain syndrome, possibly mediated through opioidergic and GABAergic mechanisms.

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“…Systemic drug therapy such as intravenous injection is the preferred way for treating many diseases, particularly cancer, is systemic medication therapy ( Aliakbar Ahovan et al, 2020 ; Arshad et al, 2021 ; Mellati et al, 2021 ). This treatment modality has been restricted by side effects, off-target accumulation, toxicity, and rapid renal and hepatic clearance ( Li et al, 2022 ; Xue et al, 2022 ). Instead, a macro therapeutic vehicle that incorporates the medicine can improve retention, reduce metabolic clearance, and lessen side effects ( Khosravimelal et al, 2021 ; Simorgh et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A novel dual MoS2/FeGA quantum dots endowed injectable hydrogel for efficient photothermal and boosting chemodynamic therapy

Liu

Zeng

et al. 2022

Front. Bioeng. Biotechnol.

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Due to its responsiveness to the tumour microenvironment (TME), chemodynamic therapy (CDT) based on the Fenton reaction to produce cytotoxic reactive oxygen species (ROS) to destroy tumor has drawn more interest. However, the Fenton’s reaction potential for therapeutic use is constrained by its modest efficacy. Here, we develop a novel injectable hydrogel system (FMH) on the basis of FeGA/MoS2 dual quantum dots (QDs), which uses near-infrared (NIR) laser in order to trigger the synergistic catalysis and photothermal effect of FeGA/MoS2 for improving the efficiency of the Fenton reaction. Mo4+ in MoS2 QDs can accelerate the conversion of Fe3+ to Fe2+, thereby promoting the efficiency of Fenton reaction, and benefiting from the synergistically enhanced CDT/PTT, FMH combined with NIR has achieved good anti-tumour effects in vitro and in vivo experiments. Furthermore, the quantum dots are easily metabolized after treatment because of their ultrasmall size, without causing any side effects. This is the first report to study the co-catalytic effect of MoS2 and Fe3+ at the quantum dot level, as well as obtain a good PTT/CDT synergy, which have implications for future anticancer research.

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Recent Advancements in Ultrasound Transducer: From Material Strategies to Biomedical Applications

Cited by 40 publications

References 131 publications

Organic–Inorganic Hybrid Perovskite Materials for Ultrasonic Transducer in Medical Diagnosis

Organic–Inorganic Hybrid Perovskite Materials for Ultrasonic Transducer in Medical Diagnosis

Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms

A novel dual MoS2/FeGA quantum dots endowed injectable hydrogel for efficient photothermal and boosting chemodynamic therapy

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