Recent advancements in two‐dimensional nanomaterials for drug delivery

Mei, Xuan; Hu, Tingting; Wang, Yingjie; Weng, Xisheng; Liang, Ruizheng; Wei, Min

doi:10.1002/wnan.1596

Cited by 39 publications

(27 citation statements)

References 159 publications

(280 reference statements)

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“…Understanding the interactions between nanomaterials and biological systems, in particular cellular membranes, is fundamental to address important challenges such as the safe design and regulation of novel engineered nanomaterials, [ 1–3 ] development of drug delivery systems, [ 4,5 ] and membrane active nanomedicines. [ 6,7 ] Nanomaterials may interact with plasma membranes prior to cellular uptake [ 8–12 ] and with membranes of intracellular vesicles following uptake.…”

Section: Introductionmentioning

confidence: 99%

Boron Nitride Nanosheets Can Induce Water Channels Across Lipid Bilayers Leading to Lysosomal Permeabilization

et al. 2021

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While the interaction between 2D materials and cells is of key importance to the development of nanomedicines and safe applications of nanotechnology, still little is known about the biological interactions of many emerging 2D materials. Here, an investigation of how hexagonal boron nitride (hBN) interacts with the cell membrane is carried out by combining molecular dynamics (MD), liquid‐phase exfoliation, and in vitro imaging methods. MD simulations reveal that a sharp hBN wedge can penetrate a lipid bilayer and form a cross‐membrane water channel along its exposed polar edges, while a round hBN sheet does not exhibit this behavior. It is hypothesized that such water channels can facilitate cross‐membrane transport, with important consequences including lysosomal membrane permeabilization, an emerging mechanism of cellular toxicity that involves the release of cathepsin B and generation of radical oxygen species leading to cell apoptosis. To test this hypothesis, two types of hBN nanosheets, one with a rhomboidal, cornered morphology and one with a round morphology, are prepared, and human lung epithelial cells are exposed to both materials. The cornered hBN with lateral polar edges results in a dose‐dependent cytotoxic effect, whereas round hBN does not cause significant toxicity, thus confirming our premise.

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Section: Introductionmentioning

confidence: 99%

Boron Nitride Nanosheets Can Induce Water Channels Across Lipid Bilayers Leading to Lysosomal Permeabilization

et al. 2021

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“…[131][132][133][134][135][136][137] However, compared with bulk LDH, monolayer LDH (MLDH) nanosheets exhibit much higher specic surface and more combinative sites, leading to greatly enhanced surface activity for drug loading. [138][139][140][141][142][143][144][145][146][147] For example, MgAl-LDH monolayer nanosheets were employed to localize doxorubicin (DOX), 148 the DOX/MLDH showed extremely high loading efficiency (3.6 mg mg À1 (w/w)) and controllable release behavior. XRD, AFM, and HRTEM conrmed the successful preparation of the MLDH nanosheets (Fig.…”

Section: Drug Delivery Hostsmentioning

confidence: 99%

Preparation and application of layered double hydroxide nanosheets

Zhang

Song

2021

RSC Adv.

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“…The purpose of using hydrazine is to reduce silver ions to the silver metal, which is then conjugated to gold nanoparticles. A bioconjugate of hydrazine−AuNP−aptamer (Hyd−AuNP−Apt) was synthesized and reported [57]. The analysis of the silver deposited was done by square wave stripping voltammetry to determine the number of cancer cells.…”

Section: Swcnts Functionalized With Gnpop For Targeted Diagnosis Of Breast Cancermentioning

confidence: 99%

“…Tungsten disulfide WS 2 is a graphene-like layered material with a high drug loading capacity due to its large specific area [57]. WS 2 nanosheet is beneficial for various reasons, such as the presence of many active sites on its surface that can be used for surface modification.…”

Section: Biomimetic Lipid-modified Ws 2 Nanosheets For Breast Cancer Therapymentioning

confidence: 99%

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

et al. 2021

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Cancer is one of the most common causes of death and affects millions of lives every year. In addition to non-infectious carcinogens, infectious agents contribute significantly to increased incidence of several cancers. Several therapeutic techniques have been used for the treatment of such cancers. Recently, nanotechnology has emerged to advance the diagnosis, imaging, and therapeutics of various cancer types. Nanomaterials have multiple advantages over other materials due to their small size and high surface area, which allow retention and controlled drug release to improve the anti-cancer property. Most cancer therapies have been known to damage healthy cells due to poor specificity, which can be avoided by using nanosized particles. Nanomaterials can be combined with various types of biomaterials to make it less toxic and improve its biocompatibility. Based on these properties, several nanomaterials have been developed which possess excellent anti-cancer efficacy potential and improved diagnosis. This review presents the latest update on novel nanomaterials used to improve the diagnostic and therapeutic of pathogen-associated and non-pathogenic cancers. We further highlighted mechanistic insights into their mode of action, improved features, and limitations.

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Recent advancements in two‐dimensional nanomaterials for drug delivery

Cited by 39 publications

References 159 publications

Boron Nitride Nanosheets Can Induce Water Channels Across Lipid Bilayers Leading to Lysosomal Permeabilization

Boron Nitride Nanosheets Can Induce Water Channels Across Lipid Bilayers Leading to Lysosomal Permeabilization

Preparation and application of layered double hydroxide nanosheets

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

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