Recent Advancements in Schiff Base Fluorescence Chemosensors for the Detection of Heavy Metal Ions

Basheer, Sabeel M.; Rasin, Puthiyavalappil; Manakkadan, Vipin; Palakkeezhillam, Vishnunarayanan Namboothiri Vadakkedathu; Sreekanth, Anandaram

doi:10.5772/intechopen.109022

Cited by 2 publications

(2 citation statements)

References 64 publications

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“…Bearing in mind that coumarin fluorescence probes for heavy metal ions currently receive increasing interest due to their highly variable size, hydrophobicity, and chelation, in this study, we focused on the design and screening of novel fluorescent probes bearing coumarin moieties [ 75 , 91 ]. In addition, Schiff bases are attracting more and more attention in analytical fields as they provide an electron-rich environment that is favorable to binding with metal ions [ 92 ]. When combined with a fluorescence moiety such as coumarin structure, the functional groups can participate in several reactions after being in contact with metal ions so that the Schiff base ligand provides detectable signals such as emission.…”

Section: Resultsmentioning

confidence: 99%

Stability Constant and Potentiometric Sensitivity of Heavy Metal–Organic Fluorescent Compound Complexes: QSPR Models for Prediction and Design of Novel Coumarin-like Ligands

Diem-Tran,

Ho,

Tuan

et al. 2023

Toxics

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Industrial wastewater often consists of toxic chemicals and pollutants, which are extremely harmful to the environment. Heavy metals are toxic chemicals and considered one of the major hazards to the aquatic ecosystem. Analytical techniques, such as potentiometric methods, are some of the methods to detect heavy metals in wastewaters. In this work, the quantitative structure–property relationship (QSPR) was applied using a range of machine learning techniques to predict the stability constant (logβML) and potentiometric sensitivity (PSML) of 200 ligands in complexes with the heavy metal ions Cu2+, Cd2+, and Pb2+. In result, the logβML models developed for four ions showed good performance with square correlation coefficients (R2) ranging from 0.80 to 1.00 for the training and 0.72 to 0.85 for the test sets. Likewise, the PSML displayed acceptable performance with an R2 of 0.87 to 1.00 for the training and 0.73 to 0.95 for the test sets. By screening a virtual database of coumarin-like structures, several new ligands bearing the coumarin moiety were identified. Three of them, namely NEW02, NEW03, and NEW07, showed very good sensitivity and stability in the metal complexes. Subsequent quantum-chemical calculations, as well as physicochemical/toxicological profiling were performed to investigate their metal-binding ability and developability of the designed sensors. Finally, synthesis schemes are proposed to obtain these three ligands with major efficiency from simple resources. The three coumarins designed clearly demonstrated capability to be suitable as good florescent chemosensors towards heavy metals. Overall, the computational methods applied in this study showed a very good performance as useful tools for designing novel fluorescent probes and assessing their sensing abilities.

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Section: Resultsmentioning

confidence: 99%

Stability Constant and Potentiometric Sensitivity of Heavy Metal–Organic Fluorescent Compound Complexes: QSPR Models for Prediction and Design of Novel Coumarin-like Ligands

Diem-Tran,

Ho,

Tuan

et al. 2023

Toxics

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“…Schiff bases have been extensively explored as fluorescent chemosensors for detecting and monitoring hazardous cations. These cations include heavy metal ions such as mercury (Hg 2+ ), lead (Pb 2+ ), cadmium (Cd 2+ ), and other toxic metal ions that pose significant environmental and health risks [42]. These chemosensors offer significant advantages such as real-time monitoring, high sensitivity, and selectivity, making them invaluable tools in environmental monitoring, biomedical diagnostics, and industrial quality control.…”

Section: Schiff Bases As Fluorescent Chemosensors For Hazardous Ionsmentioning

confidence: 99%

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals

Musikavanhu,

Liang,

Xue

et al. 2023

Molecules

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Toxic cations, including heavy metals, pose significant environmental and health risks, necessitating the development of reliable detection methods. This review investigates the techniques and approaches used to strengthen the sensitivity and selectivity of Schiff base fluorescent chemosensors designed specifically to detect toxic and heavy metal cations. The paper explores a range of strategies, including functional group variations, structural modifications, and the integration of nanomaterials or auxiliary receptors, to amplify the efficiency of these chemosensors. By improving selectivity towards targeted cations and achieving heightened sensitivity and detection limits, consequently, these strategies contribute to the advancement of accurate and efficient detection methods while increasing the range of end-use applications. The findings discussed in this review offer valuable insights into the potential of leveraging Schiff base fluorescent chemosensors for the accurate and reliable detection and monitoring of heavy metal cations in various fields, including environmental monitoring, biomedical research, and industrial safety.

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Recent Advancements in Schiff Base Fluorescence Chemosensors for the Detection of Heavy Metal Ions

Cited by 2 publications

References 64 publications

Stability Constant and Potentiometric Sensitivity of Heavy Metal–Organic Fluorescent Compound Complexes: QSPR Models for Prediction and Design of Novel Coumarin-like Ligands

Stability Constant and Potentiometric Sensitivity of Heavy Metal–Organic Fluorescent Compound Complexes: QSPR Models for Prediction and Design of Novel Coumarin-like Ligands

Strategies for Improving Selectivity and Sensitivity of Schiff Base Fluorescent Chemosensors for Toxic and Heavy Metals

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