Recent advancements in polyethyleneimine-based materials and their biomedical, biotechnology, and biomaterial applications

Chen, Zhonghui; Lv, Ziyu; Sun, Yi‐Feng; Chi, Zhenguo; Qing, Guangyan

doi:10.1039/c9tb02271f

Cited by 154 publications

(112 citation statements)

References 164 publications

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“…[23][24][25][26][27] PEI molecule is considered a good candidate for the functionalization of other molecules, the biocompatibility and stability of MNPs, that are important in the elds of biomedicine. 28 In order to improve and simplify the synthesis for the formation of PEI-coated MNPs, we propose an effective procedure that combines co-precipitation steps in a one-step procedure in an aqueous medium. The design of PEI-MNPs has a huge importance in the heat generation via electromagnetic energy conversion.…”

Section: Introductionmentioning

confidence: 99%

One-step synthesis of polyethyleneimine-coated magnetite nanoparticles and their structural, magnetic and power absorption study

et al. 2020

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Section: Introductionmentioning

confidence: 99%

One-step synthesis of polyethyleneimine-coated magnetite nanoparticles and their structural, magnetic and power absorption study

et al. 2020

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“…It is also known that the extent of cytotoxicity has a positive relationship with polymer molecular weight. Hence, a promising strategy to reduce toxicity lies in ligand-modified low molecular weight PEIs, such as those incorporating folic acid ( 62 ) or various functional peptides ( 63 ). Yu et al .…”

Section: Hybrid Vector Systems For Transfection Enhancement and Cytotoxicity Reductionmentioning

confidence: 99%

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

Gao

2021

AAPS J

249

161

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Gene therapy has been experiencing a breakthrough in recent years, targeting various specific cell groups in numerous therapeutic areas. However, most recent clinical studies maintain the use of traditional viral vector systems, which are challenging to manufacture cost-effectively at a commercial scale. Non-viral vectors have been a fast-paced research topic in gene delivery, such as polymers, lipids, inorganic particles, and combinations of different types. Although non-viral vectors are low in their cytotoxicity, immunogenicity, and mutagenesis, attracting more and more researchers to explore the promising delivery system, they do not carry ideal characteristics and have faced critical challenges, including gene transfer efficiency, specificity, gene expression duration, and safety. This review covers the recent advancement in non-viral vectors research and formulation aspects, the challenges, and future perspectives.

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“…PEI with highly positive charge is used for gene delivery [ 117 , 118 ]. It has primary, secondary, and tertiary amines, of which two-thirds of the amines can be protonated in a physiological environment, helping escape from endosome due to proton sponge effect and release drugs to cytoplasm [ 119 ].…”

Section: Application Of Different Coating Of Inops In Cerebral Thementioning

confidence: 99%

Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

Lü

et al. 2020

Nanomaterials

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Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.

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Recent advancements in polyethyleneimine-based materials and their biomedical, biotechnology, and biomaterial applications

Abstract: Precise-synthesis strategies and integration approaches of bioinspired PEI-based systems, and their biomedical, biotechnology and biomaterial applications.

Cited by 154 publications

References 164 publications

One-step synthesis of polyethyleneimine-coated magnetite nanoparticles and their structural, magnetic and power absorption study

One-step synthesis of polyethyleneimine-coated magnetite nanoparticles and their structural, magnetic and power absorption study

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

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