Recent advancements in applications of ionic liquids in synthetic construction of heterocyclic scaffolds: A spotlight

Dhameliya, Tejas M.; Nagar, Prinsa R.; Bhakhar, Kaushikkumar A.; Jivani, Hevankumar R.; Shah, Bhavya J.; Patel, Kirti D; Patel, Vaishnavi S.; Soni, Archita H.; Joshi, Lipi P.; Gajjar, Normi D.

doi:10.1016/j.molliq.2021.118329

Cited by 36 publications

(16 citation statements)

References 749 publications

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“…Several heterocycles have been reported as anti‐infectious agents against pathogemic microorganisms[ 55 , 56 , 57 , 58 , 59 ] with their greener synthesis. [ 60 , 61 , 62 , 63 ] Following this, heterocyclic ligands such as savinin and cleistantoxin showed the inhibition of papain‐like protease (PDB ID: 6W6Y) with docking scores of −8.05 and −7.66, respectively, which are superior to the remdesivir (docking score of −7.37). In the savinin, ethereal oxygen formed HB with the amino acid Val49, and carbonyl oxygen formed HB with the residue Leu126 (Figure 5 a).…”

Section: Resultsmentioning

confidence: 96%

In‐silico Computational Investigations of AntiViral Lignan Derivatives as Potent Inhibitors of SARS CoV‐2

Sureja¹,

Shah²,

Gajjar³

et al. 2022

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Due to alarming outbreak of pandemic COVID‐19 in recent times, there is a strong need to discover and identify new antiviral agents acting against SARS CoV‐2. Among natural products, lignan derivatives have been found effective against several viral strains including SARS CoV‐2. Total of twenty‐seven reported antiviral lignan derivatives of plant origin have been selected for computational studies to identify the potent inhibitors of SARS CoV‐2. Molecular docking study has been carried out in order to predict and describe molecular interaction between active site of enzyme and lignan derivatives. Out of identified hits, clemastatin B and erythro‐strebluslignanol G demonstrated stronger binding and high affinity with all selected proteins. Molecular dynamics simulation studies of clemastin B and savinin against promising targets of SARS CoV‐2 have revealed their inhibitory potential against SARS CoV‐2. In fine, in‐silico computational studies have provided initial breakthrough in design and discovery of potential SARS CoV‐2 inhibitors.

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Section: Resultsmentioning

confidence: 96%

In‐silico Computational Investigations of AntiViral Lignan Derivatives as Potent Inhibitors of SARS CoV‐2

Sureja¹,

Shah²,

Gajjar³

et al. 2022

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“…Last decade has witnessed a paradigm shift in the way molecules are being synthesized specially the Ncontaining heterocycles. [3][4][5][42][43][44] In order to address some of the most burning questions of 21 st century i. e., the climate change and environment degradation, all domains of science and research have resorted to greener and sustainable protocols. Therefore into this pursuit, it is highly imperative to adapt to environmentally benign approaches for the synthesis of bioactive heterocycles.…”

Section: Sustainable Methods For Synthesis Of Quinolinesmentioning

confidence: 99%

Environmentally Benign Approaches towards the Synthesis of Quinolines

Kumar

Dhameliya²,

Sharma

et al. 2022

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Greener and sustainable synthetic strategies have been evolving as the demanding domain of organic transformations during the last decade. The division of an environmentally benign methodology to construct bioactive heterocyclic scaffolds has always been a perpetual subject of interests for medicinal and synthetic chemists. Thus, the newer and novel synthetic methodologies of quinoline have drawn the attention of synthetic organic or medicinal chemists as evident from the growing numbers of publications. The current review focuses on some of the notable synthetic methodologies carried out in the last decade with the inherent objective to attain sustainability towards the synthesis. The key aspects of the review would include to highlight sustainable and environmentally benign approaches like the solvent‐free reactions, use of alternate reaction media (e. g., water, fluorous alcohols, polyethylene glycols, and ionic liquids), and alternate modes of synthesis such as microwave‐assisted synthesis and flow reactions, nano‐catalysts, etc.

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“…[18] On the another part, the innovative and green synthetic strategies have given a new era of synthesis of diversely substituted heterocycles. [19][20][21] Towards the on-going research endeveour on anti-TB agents, [22][23][24][25][26][27][28][29] recently we have reported the quinquennial account of diverse scaffolds in search of agents having anti-TB profile reported during 2016-2020. [30] In this review, we have shed light on candidates having anti-TB activity (minimum inhibitory concentration, MIC or hald maximal inhibitory concentrationm IC 50 of 20 μg/mL or μM) reported during 2021 retrieved through Sci-Finder [31] to educate the reader of the present work to update with the on-going trends on design of newly identified anti-tubercular agents.…”

Section: Diverse Scaffolds Reported For Anti-tb Activitymentioning

confidence: 99%

“…Huang et al have reported pyrazole combined with sulphonamide (20) for anti-mycobacterial activity with MIC of 5.69 μg/ mL against M. tuberculosis H 37 Rv (Figure 7). Among the tried substitutions on phenyl ring attached sulfonamide, 4-methoxy have been found with better in vitro anti-mycobacterial activity against drug-susceptible and drug-resistant strain of TB along with reduced CYP 2 C9 inhibition.…”

Section: Pyrazolementioning

confidence: 99%

Comprehensive Coverage on Anti‐mycobacterial Endeavour Reported in 2021

et al. 2022

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Tuberculosis (TB) has been the highly contagious airborne disease caused by Mycobacterium tuberculosis and the major leading infectious disease with the higher upsurge of morbidity and mortality. Owing to problems in the current regimen for TB and emergence of drug resistance strains, there is a strong necessity for development of new anti-TB drugs with better efficacy, reduced duration of action, along with improved patient compliance. Towards this, the scaffolds reported in 2021 with anti-tubercular activity such as benzofuran, benzothiazinone, benzimidazoles, indole, piperidine, piperazine, pyrazole, pyridine, pyrimidine, pyrrolidine, quinoxaline, triazole, etc. have been critically reviewed along with their structureactivity relationships, mode of actions with anticipations of intuitions to design the newer anti-mycobacterial scaffolds.The present work provide the organized coverage of diversified scaffolds with anti-tubercular profile reported in 2021 along with the insightful discussion on their merits and demerits. The mode of anti-tubercular action against Mycobacterium tuberculosis strains have been presented keeping in mind the novel drug candidates against drug resistant strains [a] Dr.

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Recent advancements in applications of ionic liquids in synthetic construction of heterocyclic scaffolds: A spotlight

Cited by 36 publications

References 749 publications

In‐silico Computational Investigations of AntiViral Lignan Derivatives as Potent Inhibitors of SARS CoV‐2

In‐silico Computational Investigations of AntiViral Lignan Derivatives as Potent Inhibitors of SARS CoV‐2

Environmentally Benign Approaches towards the Synthesis of Quinolines

Comprehensive Coverage on Anti‐mycobacterial Endeavour Reported in 2021

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