2022
DOI: 10.1016/j.molstruc.2021.131473
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Recent advancements and developments in search of anti-tuberculosis agents: A quinquennial update and future directions

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Cited by 30 publications
(25 citation statements)
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“…Several heterocycles have been reported as anti‐infectious agents against pathogemic microorganisms[ 55 , 56 , 57 , 58 , 59 ] with their greener synthesis. [ 60 , 61 , 62 , 63 ] Following this, heterocyclic ligands such as savinin and cleistantoxin showed the inhibition of papain‐like protease (PDB ID: 6W6Y) with docking scores of −8.05 and −7.66, respectively, which are superior to the remdesivir (docking score of −7.37).…”
Section: Resultsmentioning
confidence: 99%
“…Several heterocycles have been reported as anti‐infectious agents against pathogemic microorganisms[ 55 , 56 , 57 , 58 , 59 ] with their greener synthesis. [ 60 , 61 , 62 , 63 ] Following this, heterocyclic ligands such as savinin and cleistantoxin showed the inhibition of papain‐like protease (PDB ID: 6W6Y) with docking scores of −8.05 and −7.66, respectively, which are superior to the remdesivir (docking score of −7.37).…”
Section: Resultsmentioning
confidence: 99%
“…[19][20][21] Towards the on-going research endeveour on anti-TB agents, [22][23][24][25][26][27][28][29] recently we have reported the quinquennial account of diverse scaffolds in search of agents having anti-TB profile reported during 2016-2020. [30] In this review, we have shed light on candidates having anti-TB activity (minimum inhibitory concentration, MIC or hald maximal inhibitory concentrationm IC 50 of 20 μg/mL or μM) reported during 2021 retrieved through Sci-Finder [31] to educate the reader of the present work to update with the on-going trends on design of newly identified anti-tubercular agents.…”
Section: Diverse Scaffolds Reported For Anti-tb Activitymentioning
confidence: 99%
“…Introspection of the recent trend on discovery of anti-TB agents highlighted the importance of several N-containing heterocyclic scaffolds [6][7][8] for their anti-TB activities. [9][10][11] Benzazoles including benzothiazoles, [12] benzimidazole, [13,14] and benzoxazole [15] have been recognized as important pharmacophoric features for anti-mycobacterial activity. Further, plethora of compounds bearing amide or carboxamides moieties have been reported for anti-TB activity.…”
Section: Designmentioning
confidence: 99%