Recent advancement of nanotherapeutics in accelerating chronic wound healing process for surgical wounds and diabetic ulcers

Prakashan, Drishya; Roberts, Akanksha; Gandhi, Sonu

doi:10.1080/02648725.2023.2167432

Cited by 10 publications

(4 citation statements)

References 148 publications

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“…By increasing the degree of antibiotic concentration, local antimicrobial therapy helps eliminate wound infections [ 61 ]. To reduce the risk of antibiotic-related side effects and resistance, antibiotics should be limited to site applications rather than systemic and long-term therapy [ 62 ].…”

Section: Applications Of Different Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain a critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to a prolonged effect. Nanomaterials have emerged as promising candidates in the field of wound healing due to their unique properties and versatile applications. New insights into the interactions between nanomaterials and wound microenvironments have shed light on the mechanisms underlying their therapeutic effects. However, a significantly minimal amount of research has been carried out to see if these nanomaterials significantly promote the wound healing process. In this review, we provided an outline of the various types of nanomaterials that have been studied for healing wounds and infection prevention. Overall, the utilization of nanomaterials in wound healing holds great promise and continues to evolve, providing new opportunities for the development of effective and efficient wound care therapies.

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Section: Applications Of Different Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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“…It has been reported in studies that GlcNAc, as the main part of epithelial, plays an essential role in wound healing. It has been shown that the injection of GlcNAc can increase the amount of HA production in surgical wounds and reduce the occurrence of side effects in the tissue repair process ( Shi et al, 2018 ; Schoukens, 2019 ; Prakashan et al, 2023 ). For example, in a study, the effect of local injection of GlcNAc on the wound healing process in rat was investigated.…”

Section: Biomaterials Used In Wound Healingmentioning

confidence: 99%

A review of the current state of natural biomaterials in wound healing applications

Ansari,

Darvishi

2024

Front. Bioeng. Biotechnol.

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Skin, the largest biological organ, consists of three main parts: the epidermis, dermis, and subcutaneous tissue. Wounds are abnormal wounds in various forms, such as lacerations, burns, chronic wounds, diabetic wounds, acute wounds, and fractures. The wound healing process is dynamic, complex, and lengthy in four stages involving cells, macrophages, and growth factors. Wound dressing refers to a substance that covers the surface of a wound to prevent infection and secondary damage. Biomaterials applied in wound management have advanced significantly. Natural biomaterials are increasingly used due to their advantages including biomimicry of ECM, convenient accessibility, and involvement in native wound healing. However, there are still limitations such as low mechanical properties and expensive extraction methods. Therefore, their combination with synthetic biomaterials and/or adding bioactive agents has become an option for researchers in this field. In the present study, the stages of natural wound healing and the effect of biomaterials on its direction, type, and level will be investigated. Then, different types of polysaccharides and proteins were selected as desirable natural biomaterials, polymers as synthetic biomaterials with variable and suitable properties, and bioactive agents as effective additives. In the following, the structure of selected biomaterials, their extraction and production methods, their participation in wound healing, and quality control techniques of biomaterials-based wound dressings will be discussed.

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“…Chronic wounds often persist in the inflammatory stage, hindering the progression to the cell proliferation and tissue remodelling phases, leading to prolonged or non-healing wounds. 31 These wounds can be categorised into clinical types based on the causative factors: ischaemic ulcers, traumatic ulcers, metabolic ulcers, pressure ulcers, venous ulcers, and others (e.g., infected ulcers, malignant ulcers, neurogenic ulcers, and radiological ulcers). 32,33 Chronic wounds exhibit prolonged inflammation, elevated ROS levels, impaired angiogenesis, inadequate re-epithelialisation, imbalanced cytokine/growth factor expression, and heightened protease activity.…”

Section: Pathology Of Chronic Woundsmentioning

confidence: 99%