Recent Advancement of Medical Patch for Transdermal Drug Delivery

Abstract

Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body. Transdermal drug delivery has several advantages over other routes of administration, for instance, it is less invasive, patient-friendly, and has the ability to bypass first-pass metabolism and the destructive acidic environment of the stomach that occurs upon the oral ingestion of drugs. For decades, transdermal patches have attracted attention and were used to deliver drugs such as nicotine, fentanyl, nitroglycerin, and clonidine to treat various diseases or conditions. Recently, this method is also being explored as a means of delivering biologics in various applications. Here, we review the existing literatures on the design and usage of medical patches in transdermal drug delivery, with a focus on the recent advances in innovation and technology that led to the emergence of smart, dissolvable/biodegradable, and high-loading/release, as well as 3D-printed patches.

Current approaches in smart nano‐inspired drug delivery: A narrative review

“…MAPs could also monitor the patients during drug therapy. 62 Smart drug delivery mechanisms like using porous particles and stimuli‐responsive gatekeepers (smart gatekeepers) as carriers were proposed for improved drug delivery. 63 These methods notably enhance drug diffusion to the affected site and improve therapeutic efficacy of the drug.…”

Designing of a new transdermal antibiotic delivery polymeric membrane modified by functionalized SBA-15 mesoporous filler

“…To overcome the challenges ahead, various routes of drug delivery have been identified, including the oral route 16 , inhalation route 17 , intravenous route 18 , subcutaneous route 19 , and transdermal route 20 . Various routes of transdermal delivery are common including: Transdermal Patches 21 : Advantages: Convenient and non-invasive method of drug delivery. Offers sustained release of medication, maintaining constant drug levels in the bloodstream.…”

“…Transdermal Patches 21 : Advantages: Convenient and non-invasive method of drug delivery. Offers sustained release of medication, maintaining constant drug levels in the bloodstream.…”

“…In this case, transdermal patches (TPs) represent a sophisticated medication delivery system that facilitates the passage of drugs through the skin and subsequent entry into the bloodstream 21 . This approach has found extensive utility across diverse therapeutic domains, including effective drug administration, hormonal replacement therapy, and nicotine cessation interventions 26 .…”

In vitro and Ex vivo study targeting the development of a Lavandula stoechas L. (Ustukhuddūs) loaded Unani Transdermal patch: Implication of Unani Medicine in the treatment of Nisyan (Dementia)

“…Nevertheless, complete potential of TDSS remains untapped due to the inherent barrier presented by the skin. A transdermal patch is a medication-infused patch designed to release drugs into the bloodstream at a controlled rate by permeating through the layers of the skin [ 3 ]. Transdermal patches, widely embraced for treating various medical conditions, are adhesive devices that contain drugs with a specific surface area.…”