Recent advancement in ultrasound-assisted novel technologies for the extraction of bioactive compounds from herbal plants: a review

Islam, Makdud; Malakar, Santanu; Rao, M. V. N.; Kumar, Navneet; Sahu, Jatindra K.

doi:10.1007/s10068-023-01346-6

Cited by 12 publications

(2 citation statements)

References 114 publications

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“…Various solvents have been used for the extraction of bioactive compounds, with the most popular ones being methanol, ethanol, and different water ratios. Currently, there is an increasing focus on research into the implementation of deep eutectic solvents, particularly environmentally friendly ones [94] . Table 3 shows the main parameters governing the extraction of bioactive compounds.…”

Section: Ultrasoundmentioning

confidence: 99%

Salvia rosmarinus Spenn. Main Applications and Ultrasonic Extraction of Secondary Metabolites: a General Review

Cedillo-Portillo,

Villastrigo-López,

Castañeda-Facio

et al. 2024

Rev. Mex. Ing. Biomed.

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This paper provides an overview of the various applications of the bioactive compounds found in S. rosmarinus. at present. Additionally, it explores emerging technologies for its extraction, such as ultrasound, which is an effective, fast, and sustainable technology for obtaining these secondary metabolites from this millenary plant. S. rosmarinus has gained considerable importance due to its beneficial properties, including antimicrobial, antioxidant, hepatoprotective, anti-inflammatory, and anticarcinogenic effects. These effects result from the different metabolites, which, without the use of ultrasound, are produced in S. rosmarinus. The main objective of this research is to provide an overview of some of the main applications in which S. rosmarinus is involved and to present a viable and effective alternative for the extraction of the different metabolites it contains using a technique such as ultrasound. The literature review was performed by searching for information on digital platforms such as SciFinder, PubMed, Scopus, and ScienceDirect, using keywords such as Rosemary, S. rosmarinus, ultrasound, green extraction, and secondary metabolite.

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Section: Ultrasoundmentioning

confidence: 99%

Salvia rosmarinus Spenn. Main Applications and Ultrasonic Extraction of Secondary Metabolites: a General Review

Cedillo-Portillo,

Villastrigo-López,

Castañeda-Facio

et al. 2024

Rev. Mex. Ing. Biomed.

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“…Nevertheless, green technologies are preferred for industrial application. This study explores the benefits of using green technology, known for its environmentally friendly processing methods and, in certain instances, as a viable substitute for conventional organic solvent-based extraction of natural products [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Nanoemulsions as Delivery Systems for Green Extracts of Pterocaulon balansae Aiming at the Treatment of Sporotrichosis

Medeiros-Neves,

Heidrich,

Schuh

et al. 2024

Pharmaceutics

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Coumarins are benzopyrones found in several plant genera, including Pterocaulon (Asteraceae). These compounds represent an important source of new treatments, especially as antimicrobial and antifungal agents. In this study, two coumarin-rich extracts from Pterocaulon balansae using green technologies were obtained through aqueous maceration (AE) and supercritical fluid extraction (SFE). Such extracts were incorporated into nanoemulsions (NAE and NSFE) composed of a medium-chain triglyceride oil core stabilized by phospholipids. The nanoemulsions exhibited droplet sizes between 127 and 162 nm, pH above 5.0, and viscosity of approximately 1.0 cP, properties compatible with the topical route. The coumarins permeation/retention from formulations through ear porcine skin using Franz-type diffusion cells were evaluated. Whatever the extract, coumarins were distributed in skin layers, especially in the dermis in both intact and impaired (tape stripping) skin. In addition, a significant increase in coumarins that reached up to the receptor fluid was observed for impaired skin, with increases of approximately threefold for NAE and fourfold for NSFE. Finally, antifungal activity of nanoemulsions was evaluated according to minimum inhibitory concentrations, and the values were 250 µg/mL for all strains tested. The overall results demonstrated the feasibility of incorporating P. balansae extracts into nanoemulsions and showed a potential alternative for the treatment of sporotrichosis.

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Tisochrysis lutea as a source of omega-3 polar lipids and fucoxanthin: extraction and characterization using green solvents and advanced techniques

García-García,

Ospina,

Señoráns

2024

J Appl Phycol

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The marine microalga Tisochrysis lutea is a potential and sustainable source of bioactive compounds such as carotenoids and omega-3 fatty acids. In the present work, the extraction of fucoxanthin and docosahexaenoic acid (DHA), the most abundant omega-3 fatty acid which constitutes polar lipids particularly in the brain, was studied using advanced extraction techniques with green and bio-based solvents compared to traditional extraction techniques with hazardous organic solvents. The experimental design to maximize the lipid extraction yield by ultrasound-assisted extraction (UAE) was developed, choosing as experimental factors the percentage of solvent (0, 50 and 100% of 2-methyl-tetrahydrofuran or 2-methyloxolane (2-me-THF) in ethanol), the extraction time (20, 30 and 40 min) and temperature (40, 50 and 60 ºC). The highest lipid extraction yields were obtained using ethanol as solvent. Nevertheless, the most interesting extracts based on their chemical composition were obtained when the presence of 2-me-THF in the extraction mixture was greater than that of ethanol. Through analytical techniques such as HPLC-ELSD/DAD and GC-MS as well as spectrophotometric techniques, the contents of polar lipids, fatty acids, total carotenoids and fucoxanthin were quantified. In addition, the antioxidant capacity of different selected extracts was studied, being once again the most interesting those extracted with different amounts of 2-me-THF due to its selectivity and enriched composition in high-added value bioactives, mainly fucoxanthin and DHA. Therefore, it is shown the importance of choosing an advanced extraction technique together with the use of green solvents not only to develop procedures that are in agreement with Green Chemistry but also to preserve its bioactivity.

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Recent advancement in ultrasound-assisted novel technologies for the extraction of bioactive compounds from herbal plants: a review

Cited by 12 publications

References 114 publications

Salvia rosmarinus Spenn. Main Applications and Ultrasonic Extraction of Secondary Metabolites: a General Review

Salvia rosmarinus Spenn. Main Applications and Ultrasonic Extraction of Secondary Metabolites: a General Review

Topical Nanoemulsions as Delivery Systems for Green Extracts of Pterocaulon balansae Aiming at the Treatment of Sporotrichosis

Tisochrysis lutea as a source of omega-3 polar lipids and fucoxanthin: extraction and characterization using green solvents and advanced techniques

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