Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics

Abstract

Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic, antipyretic, etc. Due to the expansion of pyrazolecent red pharmacological molecules at a quicker pace, there is an urgent need to put emphasis on recent literature with hitherto available information to recognize the status of this scaffold for pharmaceutical research. The reported potential pyrazole-containing compounds are highlighted in the manuscript for the treatment of cancer and inflammation, and the results are mentioned in % inhibition of inflammation, % growth inhibition, IC50, etc. Pyrazole is an important heterocyclic moiety with a strong pharmacological profile, which may act as an important pharmacophore for the drug discovery process. In the struggle to cultivate suitable anti-inflammatory and anticancer agents, chemists have now focused on pyrazole biomolecules. This review conceals the recent expansion of pyrazole biomolecules as anti-inflammatory and anticancer agents with an aim to provide better correlation among different research going around the world.

Energetic Features of H-Bonded and π-Stacked Assemblies in Pyrazole-Based Coordination Compounds of Mn(II) and Cu(II): Experimental and Theoretical Studies

“…In a similar way, pyrazole ligand complexes, with their diverse structural configurations, exhibit significant efficacy and versatility across various fields, including medicine, catalysis, separations, bio-mimetic chemistry, optics, magnetism, and luminescence [34][35][36][37]. Pyrazole complexes, exhibiting diverse pharmacological activities including antifungal [38,39], antibacterial [40], and anticancer properties, have been identified as pivotal contributors in the development of innovative drugs [41][42][43][44]. Furthermore, there is growing interest in the coordination chemistry of transition metal-based drugs, driven by their potential applications in cancer treatment [45][46][47].…”

Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control Rhizoctonia solani

“…Pyrazole, a five-membered heterocyclic ring, is an important scaffold with diverse pharmacological activities such as anticancer, , antimicrobial, , antimalarial, anti-inflammatory, and other activities. − Particularly, the pyrazole ring also plays a crucial role in the development of chemical fungicides. For example, among the 24 commercial SDHI fungicides, up to 12 commercial SDHI fungicides possess a pyrazole fragment (Figure ).…”

New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study

“…Furthermore, the pyrazoline is a prevalent structural motif included in many pharmaceutically active compounds 17 . Numerous compounds based on 4,5-dihydropyrazole have demonstrated a variety of biological functions, such as anti-tumor 18 , anti-inflammatory 19 , and antimicrobial 20 , Many of them are currently being tested and/or clinically evaluated for new drug discovery.…”