Recent advancement challenges with synthesis of biocompatible hemodialysis membranes

Zaman, Shafiq Uz; Rafiq, Sikander; Ali, Abulhassan; Mehdi, Muhammad; Arshad, Amber; Rehman, Saifur; Muhammad, Nawshad; Irfan, Muhammad; Khurram, Muhammad Shahzad; Zaman, Muhammad; Hanbazazah, Abdulkader S.; Lim, Hooi Ren; Show, Pau Loke

doi:10.1016/j.chemosphere.2022.135626

Cited by 18 publications

(12 citation statements)

References 140 publications

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“…231−233 The hemodialysis membrane is the most commonly used medical device in the field of blood purification technology. 234 It employs the principle of a semipermeable membrane to achieve the purpose of blood purification by diffusing and separating the dialysate of patients. 235 For a hemodialysis membrane, it is essential to meet the standard of excellent functionality, stability, and biocompatibility.…”

Section: Medical Devices Based On Anticoagulant Macromoleculesmentioning

confidence: 99%

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Anticoagulant Macromolecules

et al. 2023

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Anticoagulant macromolecules have gained widespread use in the clinical treatment of cardiovascular diseases, blood-contacting or implantable materials, and medical devices due to their excellent anticoagulant properties. Inspired by the molecular characteristics of physiological anticoagulants that play a vital role in normal human coagulation and anticoagulation mechanisms, diverse anticoagulant macromolecules with special molecular structures and functional groups have been developed, where they can be systematically applied to the biomedical field. In this Perspective, the history and the recent progress of synthetic methods for anticoagulant macromolecules obtained by purification of natural products, semisynthetic methods, and synthetic methods are discussed from the aspect of molecular design. The critical application and immense development potential of these anticoagulant macromolecules in the field of clinical treatment and biomedicine is proposed.

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Section: Medical Devices Based On Anticoagulant Macromoleculesmentioning

confidence: 99%

“…The hemodialysis membrane is the most commonly used medical device in the field of blood purification technology . It employs the principle of a semipermeable membrane to achieve the purpose of blood purification by diffusing and separating the dialysate of patients .…”

Section: Applications Of Anticoagulant Macromoleculesmentioning

confidence: 99%

Anticoagulant Macromolecules

et al. 2023

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“…32 The peak intensity reduced due to addition of fibroin content that might be due to better homogeneity, and layering of fibroin over membrane composition that might resulted in reduced peak intensity. 33 Only physical interactions happened among filler and polymer matrix. The minor interaction of -NH, and -CO functional group of fibroin with polymer configuration might be the motive behind better dispersion, interaction, and homogeneity between polymer composition with fibroin additive.…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Experimental investigation of fibroin content in polymethyl methacrylate‐based membranes for removal of heavy metals in aqueous solutions

Umar

Farooq

Mehdi

et al. 2023

Polymer Engineering & Sci

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Membrane technology has recently been given extensive consideration for the treatment of effluent to remove suspended solids, organic compounds and inorganic contaminants such as heavy metals. The aim of this study was to prepare, characterize, and test membranes made of silk fibroin (SF) and polymethyl methacrylate (PMMA) blend with different wt% ratios (5%, 10%, and 15%), respectively. The membranes were prepared by phase inversion scheme using water as non‐solvent. Fourier transform infrared spectroscopy (FTIR) was performed to find chemical interactions between polymer matrix and fibroin. The mechanical property of synthesized membranes was also carried out. The surface roughness, and finger‐like pore geometry developed by impregnation of fibroin filler in membrane matrix were depicted by atomic force microscopy (AFM) and scanning electron microscope (SEM), respectively. Surface porosity improved from 4.5% ± 1.9% to 30.0% ± 2.8%, water contact angle reduced from 68° ± 3.0° to 38° ± 1.2°, and highest pure water permeation value (31 L m−2 h−1) was obtained with the addition of fibroin loading. The membrane showed a greater affinity for Cr(VI) in comparison with Pb(II). The highest % rejection was evaluated to be 83% and 56% for Cr(VI), and Pb(II) by utilizing 1.70 wt% fibroin filler in membrane composition, respectively.

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“…Therefore, scientists are still researching to enhance the biocompatibility and antibacterial behavior of polymeric hemodialysis membranes. 6,7 Synchronously, less allergic, less cloggable, and more biocompatible ceramic membranes and clay mixtures have also been investigated as alternative materials for polymer and polymer-based composites. 8,9 With increasing progress in the development of nanomaterials and nanotechnology, the volume and weight of the blood filtration systems are drastically reduced, and the patient's life quality has increased after the emergence of artificial kidneys (AKs).…”

Section: ■ Introductionmentioning

confidence: 99%

“…During the last 15 years, the number of patients struggling with chronic kidney disease (CKD) has increased, although most reasons of CKD, such as genetics and smoking habits, are well known and shared with the community. − Unlike acute kidney disease, a definitive treatment has not been found yet for CKD, considering that conventional devices reduce a patient’s daily activities and comfort. , Although high-flux hemodialysis machines are extremely efficient in shortening a patient’s hospital retention time by assisting in increasing the reduced glomerular filtration rate (GFR) due to CKD, mechanically stable polymeric membranes inside the dialyzers may cause allergic reactions during operation. Therefore, scientists are still researching to enhance the biocompatibility and antibacterial behavior of polymeric hemodialysis membranes. , Synchronously, less allergic, less cloggable, and more biocompatible ceramic membranes and clay mixtures have also been investigated as alternative materials for polymer and polymer-based composites. , …”

Section: Introductionmentioning

confidence: 99%

Electrostatic Repulsive Features of Free-Standing Titanium Dioxide Nanotube-Based Membranes in Biofiltration Applications

2023

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This study presents the electrostatic repulsive features of electrochemically fabricated titanium dioxide nanotube (NT)-based membranes with different surface nanomorphologies in cross-flow biofiltration applications while maintaining a creatinine clearance above 90%. Although membranes exhibit antifouling behavior, their blood protein rejection can still be improved. Due to the electrostatically negative charge of the hexafluorotitanate moiety, the fabricated biocompatible, superhydrophilic, free-standing, and amorphous ceramic nanomembranes showed that about 20% of negatively charged 66 kDa blood albumin was rejected by the membrane with ∼100 nm pores. As the nanomorphology of the membrane was shifted from NTs to nanowires by varying fabrication parameters, pure water flux and bovine serum albumin (BSA) rejection performance were reduced, and the membrane did not lose its antifouling behavior. Herein, nanomembranes with different surface nanomorphologies were fabricated by a multi-step anodic oxidation process and characterized by scanning electron microscopy, atomic force microscopy, water contact angle analysis, X-ray diffraction, and energy-dispersive X-ray spectroscopy. The membrane performance of samples was measured in 3D printed polyethylene terephthalate glycol flow cells replicating implantable artificial kidney models to determine their blood toxin removal and protein loss features. In collected urine mimicking samples, creatinine clearances and BSA rejections were measured by the spectrophotometric Jaffe method and high-performance liquid chromatography.

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Recent advancement challenges with synthesis of biocompatible hemodialysis membranes

Cited by 18 publications

References 140 publications

Anticoagulant Macromolecules

Anticoagulant Macromolecules

Experimental investigation of fibroin content in polymethyl methacrylate‐based membranes for removal of heavy metals in aqueous solutions

Electrostatic Repulsive Features of Free-Standing Titanium Dioxide Nanotube-Based Membranes in Biofiltration Applications

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