Recent advancement and development of chitin and chitosan-based nanocomposite for drug delivery: Critical approach to clinical research

Ahmad, Awais; Mubarak, Nabisab Mujawar; Naseem, Khalida; Tabassum, Hina; Rizwan, Muhammad; Najda, Agnieszka; Kashif, Muhammad; Bin-Jumah, May; Hussain, Afzal; Shaheen, Asma; Abdel-Daim, Mohamed M.; Ali, Shafaqat; Hussain, Shahid

doi:10.1016/j.arabjc.2020.10.019

Cited by 67 publications

(33 citation statements)

References 215 publications

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“…These nanocomposites range from hydrogels, microspheres, and films with applications in the biomedical field (e.g., DDS, cancer therapy, and anti-coagulants; cf. Table 1 , Reference [ 66 ]). Karoyo and Wilson [ 67 ] have reported the formation of βCD-based hydrogel by chemical crosslinking with a bifunctional hexamethylene diisocyanate (HDI) molecules.…”

Section: Fabrication Of Bio-based Hydrogelsmentioning

confidence: 99%

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

2021

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Hydrogels are hydrophilic 3D networks that are able to ingest large amounts of water or biological fluids, and are potential candidates for biosensors, drug delivery vectors, energy harvester devices, and carriers or matrices for cells in tissue engineering. Natural polymers, e.g., cellulose, chitosan and starch, have excellent properties that afford fabrication of advanced hydrogel materials for biomedical applications: biodegradability, biocompatibility, non-toxicity, hydrophilicity, thermal and chemical stability, and the high capacity for swelling induced by facile synthetic modification, among other physicochemical properties. Hydrogels require variable time to reach an equilibrium swelling due to the variable diffusion rates of water sorption, capillary action, and other modalities. In this study, the nature, transport kinetics, and the role of water in the formation and structural stability of various types of hydrogels comprised of natural polymers are reviewed. Since water is an integral part of hydrogels that constitute a substantive portion of its composition, there is a need to obtain an improved understanding of the role of hydration in the structure, degree of swelling and the mechanical stability of such biomaterial hydrogels. The capacity of the polymer chains to swell in an aqueous solvent can be expressed by the rubber elasticity theory and other thermodynamic contributions; whereas the rate of water diffusion can be driven either by concentration gradient or chemical potential. An overview of fabrication strategies for various types of hydrogels is presented as well as their responsiveness to external stimuli, along with their potential utility in diverse and novel applications. This review aims to shed light on the role of hydration to the structure and function of hydrogels. In turn, this review will further contribute to the development of advanced materials, such as “injectable hydrogels” and super-adsorbents for applications in the field of environmental science and biomedicine.

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Section: Fabrication Of Bio-based Hydrogelsmentioning

confidence: 99%

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

2021

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“…The lowest relative density is observed when the Cr2O3 content is 40 wt.%, and the relative density of the sample A-40C is 87.23%. Firing shrinkage is the combined effect of sintering and thermal transformation/reaction [13]. A certain amount of volume shrinkage occurs after sintering during the preparation of the composite material.…”

Section: Consolidation Behaviourmentioning

confidence: 99%

“…Al2O3 and Cr2O3 have the same hexagonal crystal structure; they can form a complete substitutional solid solution (Al1-xCrx)2O3 (0 ≤ x ≤ 1) at high temperature in the whole composition range without any sign of eutectic [12,13]. The solubility of Cr2O3 in coal gasification slag (SiO2-CaO system) and various glass melts is much smaller than that of other oxide materials, so Cr2O3 or refractories containing Cr2O3 have good corrosion resistance to steel slag, non-ferrous smelting slag, coal gasification slag, oil-gas furnace slag, solid incinerator, and various glass melts [14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cr2O3 Content on Microstructure and Mechanical Properties of Al2O3 Matrix Composites

Cui

Zhang

et al. 2021

Coatings

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Al2O3-Cr2O3 refractories are completely substitution solid solutions and can effectively resist slag erosion when used as an industrial furnace lining. In order to provide suitable chromium corundum refractory with excellent slag resistance and mechanical properties for smelting reduction ironmaking, Al2O3-Cr2O3 samples with different mass percentages (0, 10, 20, 30, 40 wt.%) of Cr2O3 were prepared by a normal pressure sintering process to study its sintering properties, mechanical properties, thermal shock resistance, and microstructure. The results of densification behavior showed that the introduction of Cr2O3 deteriorates the compactness, the relative density and volume shrinkage rate of the composite material decrease with the increase of the Cr2O3 content, and the apparent porosity increases accordingly. In terms of mechanical properties, the hardness, compressive strength, and flexural strength of Al2O3-Cr2O3 material decrease gradually with the increase of Cr2O3. After 10 and 20 thermal shock cycles, the flexural strengths of the samples all decreased. With the increase of Cr2O3 in these samples, the loss rate of flexural strength gradually increased. Considering the slag resistance and mechanical properties of the composite material, the Al2O3-Cr2O3 composite refractory with Cr2O3 content of 20–30% can meet the requirements of smelting reduction iron making kiln lining.

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“…It is composed of thousands of particles of N-acetylglucosamine, which is a kind of glucosamine ((1,4)-2-amino-2-deoxy-β-D-glucan) polysaccharide. Its sources are widely distributed and can be found in arthropods, mollusks, algae, and fungi, including the crustaceans of crabs, shrimps and other marine animals [ 52 ]. Chitosan is a product obtained by the deacetylation of chitin.…”

Section: Inorganic Particles Used In Dentistrymentioning

confidence: 99%

Biopolymers Hybrid Particles Used in Dentistry

Chen

Lee

Huang

2021

Gels

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This literature review provides an overview of the fabrication and application of biopolymer hybrid particles in dentistry. A total of 95 articles have been included in this review. In the review paper, the common inorganic particles and biopolymers used in dentistry are discussed in general, and detailed examples of inorganic particles (i.e., hydroxyapatite, calcium phosphate, and bioactive glass) and biopolymers such as collagen, gelatin, and chitosan have been drawn from the scientific literature and practical work. Among the included studies, calcium phosphate including hydroxyapatite is the most widely applied for inorganic particles used in dentistry, but bioactive glass is more applicable and multifunctional than hydroxyapatite and is currently used in clinical practice. Today, biopolymer hybrid particles are receiving more attention as novel materials for several applications in dentistry, such as drug delivery systems, bone repair, and periodontal regeneration surgery. The literature published on the biopolymer gel-assisted synthesis of inorganic particles for dentistry is somewhat limited, and therefore, this article focuses on reviewing and discussing the biopolymer hybrid particles used in dentistry.

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Recent advancement and development of chitin and chitosan-based nanocomposite for drug delivery: Critical approach to clinical research

Cited by 67 publications

References 215 publications

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

Effects of Cr2O3 Content on Microstructure and Mechanical Properties of Al2O3 Matrix Composites

Biopolymers Hybrid Particles Used in Dentistry

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