Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa

Lim, Taehyeong; Ham, So-Young; Nam, Sangjin; Kim, Myoungsun; Lee, Ki Yong; Park, Hee-Deung; Byun, Youngjoo

doi:10.3390/antibiotics11020274

Cited by 10 publications

(3 citation statements)

References 55 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These three systems together form an intricate hierarchical quorum-sensing circuitry ( Figure 1 ) [ 11 ]. Among the three QS systems, las is at the top of the QS hierarchy and is required for the optimal activation of the rhl and pqs QS systems [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Shen

Wang

et al. 2022

Marine Drugs

View full text Add to dashboard Cite

The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the goals of survival and reproduction. Quorum sensing (QS) is an intercellular communication system based on cell density that can regulate bacterial virulence and biofilm formation. The secretion of more than 30 virulence factors of P. aeruginosa is controlled by QS, and the formation and diffusion of biofilm is an important mechanism causing the multidrug resistance of P. aeruginosa, which is also closely related to the QS system. There are three main QS systems in P. aeruginosa: las system, rhl system, and pqs system. Quorum-sensing inhibitors (QSIs) can reduce the toxicity of bacteria without affecting the growth and enhance the sensitivity of bacterial biofilms to antibiotic treatment. These characteristics make QSIs a popular topic for research and development in the field of anti-infection. This paper reviews the research progress of the P. aeruginosa quorum-sensing system and QSIs, targeting three QS systems, which will provide help for the future research and development of novel quorum-sensing inhibitors.

show abstract

Section: Introductionmentioning

confidence: 99%

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Shen

Wang

et al. 2022

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Secretion of virulence factors by this bacterium is controlled by a mechanisms called Quorum sensing (QS) by which bacteria can communicate with the same species or other microbes in order to achieve a specific process associated with the virulence. QS network produced by P. aeruginosa is responsible for pyocyanin production and other virulence factors, which makes the bacteria highly drug-resistant (Tang et al, 2021;Lim et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Expression of rhlR gene in Pseudomonas aeruginosa affected by Lactobacillus spp

2022

pnr

View full text Add to dashboard Cite

P. aeruginosa is an opportunistic pathogen causes severe infections due to distinct virulence factors such as pyocyanin. This pigment confers the microbe severity during the infections. This study aimed to evaluate metabolites from Lactobacillus on pyocyanin production. Seven isolates of P. aeruginosa were screened for pyocyanin. All the isolates were produced pyocyanin in rate ranged between 0.47 to 0.82 µg/ml. The isolates were AHL producers with absorbance at 630 nm ranged between 2.26 to 4.88. The culture filtrate from Lactobacillus spp. showed inhibition activity against pyocyanin production. The clinical Lactobacillus spp. was characterised by their higher ability to inhibit pyocyanin production compared to the environmental isolate. There was a clear variation in folding change values in expression of rhlR gene after treatment with Lactobacillus filtrate. Treatment with CF of Lac9 was up-regulated 1.89-Fold the transcription of rhlR gene. The results of this study suggest that there is a clear interaction between P. aeruginosa and Lactobacillus regarding the pyocyanin production.

show abstract

“…In view of these questions, chemical tools are now starting to be developed to delineate the function of all three of the LuxR-type receptors in P. aeruginosa QS, with potent ligands that modulate RhlR featuring prominently in the past ∼7–8 years. − …”

mentioning

confidence: 99%

Small Molecules with Either Receptor-Selective or Pan-Receptor Activity in the Three LuxR-Type Receptors that Regulate Quorum Sensing in Pseudomonas aeruginosa

2022

View full text Add to dashboard Cite

Quorum sensing (QS) allows bacteria to assess their local cell density using chemical signals and plays a prominent role in the ability of common pathogens to infect a host. Non-native molecules capable of attenuating bacterial QS represent useful tools to explore the role of this pathway in virulence. As individual bacterial species can have multiple QS systems and/or reside in mixed communities with other bacteria capable of QS, chemical tools that are either selective for one QS system or “pan-active” and target all QS pathways are of significant interest. Herein we outline the analysis of a set of compounds reported to target one QS system in Pseudomonas aeruginosa for their activity in two other QS circuits in this pathogen and the discovery of molecules with novel activity profiles, including subsets that agonize all three QS systems, agonize one but antagonize the other two, or strongly antagonize just one.

show abstract

Recent Advance in Small Molecules Targeting RhlR of Pseudomonas aeruginosa

Cited by 10 publications

References 55 publications

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

Expression of rhlR gene in Pseudomonas aeruginosa affected by Lactobacillus spp

Small Molecules with Either Receptor-Selective or Pan-Receptor Activity in the Three LuxR-Type Receptors that Regulate Quorum Sensing in Pseudomonas aeruginosa

Contact Info

Product

Resources

About