Recent advance in management of herpes simplex in Japan

Imafuku, Shinichi

doi:10.1111/1346-8138.16734

Cited by 2 publications

(3 citation statements)

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“…HSV-1 is a ubiquitous but important human pathogen. Recent epidemiologic studies estimate that over half of the world's population is infected with HSV-1, making it a global health concern (James et al, 2020 ; Imafuku, 2023 ). HSV-1 initially prefers to infect the genital and oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…In brief, HSV-1 infection begins with primary infection in the periphery, followed by lifelong latency in the peripheral nervous system, which can cause various clinical signs and symptoms, such as skin lesions, acute retinal necrosis, genital sores, and other pathologies (Khalesi et al, 2023 ). Furthermore, HSV-1 can cause fatal systemic infections or encephalitis, problems typically most associated with immune naive or immunocompromised patients (Imafuku, 2023 ). HSV-1 has been reported to be the most common cause of infectious blindness and fatal encephalitis worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…HSV-1 has been reported to be the most common cause of infectious blindness and fatal encephalitis worldwide. It can also cause Bell's palsy when it infects the facial nerve, an acute spontaneous facial paralysis that accounts for 50–70% of all peripheral facial paralysis (Imafuku, 2023 ; Khalesi et al, 2023 ). Reactivation of latent HSV-1 infection in the geniculate ganglion is considered a major cause of Bell's palsy.…”

Section: Introductionmentioning

confidence: 99%

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Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

Guo

Tan

et al. 2023

Front. Microbiol.

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Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%