Recent Achievements in the Synthesis of Oxazoles

Abstract

: Oxazole-containing compounds have diverse biological activities, such as antimicrobial, anticancer, antitubercular, anti-inflammatory, antidiabetic, antiobesity, antimalarial, and antiviral activities, and some of them have been used as drugs for disease treatment. They also play important roles in the synthesis of bioactive natural products, pharmaceuticals, and synthetic transformations, as well as in materials, catalysts, and agricultural fields. Thus, the development of more efficient and facile synthetic approaches to access oxazole compounds has attracted the intensive interest of chemists, and diverse methods for their synthesis have been investigated. Various established methods have been improved and modified, while numerous novel methods have been discovered. This article summarizes considerable studies on the construction of the oxazole skeleton, which date back to 2014.

Recent achievements in the synthesis of benzimidazole derivatives

“…The article might be useful for chemists who work in pharmaceuticals, organic synthesis, and the synthesis of heterocycles. We have previously produced reviews on the synthesis of furans, pyrroles, thiophenes, benzofurans, benzothiophenes, oxazoles, isoxazoles, and thiazoles, [62][63][64][65][66][67][68][69] and this article is a continuation of our investigation into the synthesis of aromatic ve-membered ring heterocycles.…”

Metal-free electrochemical oxidative intramolecular cyclization ofN-propargylbenzamides: facile access to oxazole ketals

“…In the past decade, N -propargylamides, commonly used and easily prepared building blocks, have gained significant popularity in the preparation of synthetically and structurally useful oxazole derivatives. 4 Recent research studies have focused on transition-metal (such as Au, Cu, Pd, Fe, Ag etc .) catalyzed, 5 iodine-promoted, 6 or visible-light-catalyzed 7 intramolecular cyclization reactions of N -propargylamides to construct attractive oxazole skeletons (Scheme 1a).…”