Recent achievements in solidified floating organic drop microextraction

Viñas, Pilar; Campillo, Natalia; Andruch, Vasiľ

doi:10.1016/j.trac.2015.02.005

Cited by 94 publications

(44 citation statements)

References 219 publications

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“…Para a posterior formação da gota solidificada, um pré-tratamento é necessário para amostras muito complexas. O procedimento utilizado neste trabalho é comum em amostras de urina [10,23] Antes de qualquer experimento, as amostras de urina hidrolisada tiveram o pH ajustado para 1 com a adição de 330 μL de H3PO4 (10 mol L -1 ) e, em seguida, foram misturadas com 4 mL de acetonitrila. A solução foi agitada manualmente por 1 min, levada a ultrassom por 10 min e, posteriormente, centrifugada por 5 min a 3500 rpm.…”

Section: Procedimento De Hidrólise Do Glicuronídeo E Extração Por Ultunclassified

“…No entanto, concentrações mais altas de NaCl (2 e 3 %) reduzem a capacidade de difusão dos analitos na fase aquosa em direção às gotículas do solvente extrator, haja vista que o cloreto de sódio é um agente espessante e, por isso, aumenta a viscosidade do meio [10]. Com base nos resultados obtidos, foi definida a adição de 1% de NaCl.…”

Section: Figura 4 (A) Efeito Do Volume Do Solvente De Dispersão Na Dunclassified

“…Em nosso estudo foi alcançado com menos de 1 minuto. Essa vantagem já foi observada com relação à tecnica SFODME [10]. …”

Section: Figura 4 (A) Efeito Do Volume Do Solvente De Dispersão Na Dunclassified

“…As técnicas de microextração, portanto, são as mais estudadas atualmente, com destaque para a microextração em fase sólida (Solid Phase Microextraction, SPME) [3] e a microextração em fase líquida (Liquid Phase Microextraction, LPME) [7] com as suas variações; como a microextração em fase líquida com fibra oca (Hollow Fiber Liquid Phase Microextraction, HF-LPME) [8], a microextração em fase líquida com gota suspensa (Single Drop Microextraction, SDME) [9], microextração com solidificação da gota orgânica flutuante (Solidified Fluoating Organic Drop Microextraction, SFODME) [10] e a microextração líquido-líquido dispersiva (Dispersive Liquid-Liquid Microextraction, DLLME) [11,12]. Esta última abriu novas possibilidades de combinação com outras técnicas [7], dentre elas a microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante (Dispersive Liquid-Liquid Microextraction -Solidification of a Floating Organic Drop, DLLME-SFO) [13].…”

Section: Introductionunclassified

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Aplicação da microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante para determinação de 11-nor-9-carboxi-Δ9-tetraidrocanabinol em urina humana com derivação on-line no sistema de injeção cromatográfico

Dórea

Gomes²,

Prata³

et al. 2017

Scientia Plena

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Determinação de 11-nor-9-carboxi-Δ 9 -tetraidrocanabinol em urina humana por microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante e derivação online no sistema de injeção cromatográficoDetermination of 11-nor-9-carboxy-δ9-tetrahydrocannabinol in human urine by dispersive liquid-liquid microextraction with solidification of a floating organic drop and on-line derivatization in the injection system chromatographic H. A Cannabis sativa é a droga de abuso mais consumidas no mundo. Devido à baixa concentração dos metabólitos em amostras complexas, novas técnicas de extração estão sendo estudadas. O objetivo desse trabalho foi aplicar a Microextração Líquido-Líquido Dispersiva com Solidificação da Gota Orgânica Flutuante (DLLME-SFO) para determinar o 11-nor-9-carboxi-Δ 9 -tetraidrocanabinol (THC-COOH) em urina humana. Além disso, estabelecer um procedimento on line para a derivação do metabólito no injetor cromatográfico. O analito foi extraído da urina depois da hidrólise alcalina do glicuronídeo, usando o solvente de extração 1-dodecanol (30 µL) e o metanol (200 µL) como dispersor. NaCl 1% foi adicionado e o tempo de extração foi de 5 min. A melhor proporção entre BSTFA:extrato para derivação on line do THC-COOH foi 2:2, injetor operado no modo split 1:20 e temperatura de 240 °C. O extrato foi analisado por cromatografia gasosa acoplada a espectrometria de massas no modo tandem (GC-MS/MS), depois da definição dos ions pais (m/z), da energia de excitação (modo ressonante) e dos ions filhos para a quantificação e confirmação (m/z) do canabinóide e do padrão interno deuterado. Os limites de detecção (LD) e de quantificação (LQ) foram 1 e 10 ng mL -1 , respectivamente. O método analítico proposto apresentou vantagens com relação à sensibilidade, especificidade, linearidade e custo com relação à extração em fase sólida, assim como é adequado à química verde e seus limites são apropriados para analisar THC-COOH em urina humana.Palavras-chave: THC-COOH, urina, DLLME-SFO.Cannabis sativa is the most used drug in the world. Due to the low concentration of metabolites in complex samples, new extraction techniques are being studied. The objective of this study was to develop an analytical method by applying the technique of Dispersive Liquid-Liquid MicroextractionSolidification of a Floating Organic Drop (DLLME-SFO) to determine 11-nor -9-carboxyl -Δ 9 -tetrahydrocannabinol (THC-COOH) in human urine sample. In addition, it was established an online procedure for derivatisation of the metabolite in the chromatographic injector. After of the glucuronide alkaline hydrolysis, the analyte was extracted with 1-dodecanol (30 µL) and methanol (200 µL), as extraction and dispersive solvents, respectively, addition of 1 % NaCl and 5 min to extraction time. The best proportion between BSTFA:extract for on line derivatization of the THC-COOH was 2:2, the split was 1:20 and 240 °C for temperature. The extract was analyzed by gas chromatography coupled to tandem mass spectrometry (GC-MS/MS), after definition ...

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Section: Procedimento De Hidrólise Do Glicuronídeo E Extração Por Ultunclassified

Section: Figura 4 (A) Efeito Do Volume Do Solvente De Dispersão Na Dunclassified

“…Em nosso estudo foi alcançado com menos de 1 minuto. Essa vantagem já foi observada com relação à tecnica SFODME [10]. …”

Section: Figura 4 (A) Efeito Do Volume Do Solvente De Dispersão Na Dunclassified

Section: Introductionunclassified

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Aplicação da microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante para determinação de 11-nor-9-carboxi-Δ9-tetraidrocanabinol em urina humana com derivação on-line no sistema de injeção cromatográfico

Dórea

Gomes²,

Prata³

et al. 2017

Scientia Plena

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“…28 Nowadays, based on principals of green chemistry, liquid phase microextraction techniques have become very popular and many new and microextraction techniques have been developed based on classical liquid-liquid extraction. 29 Of these, we can name headspace single drop microextraction, 30 direct immersion single drop microextraction, 31 solidification of floating organic drop microextraction, 32 dispersive liquid-liquid microextraction, 33 narrow bore dispersive liquid-liquid microextraction, 34 and cold induced dispersive liquid-liquid microextraction. 35 In all of these techniques extractant must be an organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Application of a Novel Micro-Cloud Point Extraction for Preconcentration and Spectrophotometric Determination of Azo Dyes

Ghasemi¹,

Kaykhaii²

2016

Journal of the Brazilian Chemical Society

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A novel room temperature micro-cloud point extraction procedure using triton X-114 surfactant as extracting phase was developed for preconcentration and extraction of three azo dyes (orange G, methyl orange, and acid red 18) from aqueous samples using molecular absorption spectrophotometry in the visible region. The effects of different parameters such as concentration of surfactant and added salting out reagent (Na 2 SO 4 ), pH and type of diluting solvent on microextraction were studied and optimized. Under optimum conditions, calibration curves were linear in the range of 2.0-10.0, 0.2-1.0 and 2-12 mg L -1 with the detection limit of 1.6, 0.6 and 111.0 μg L -1 for orange G, methyl orange and acid red 18, respectively. The relative standard deviation was better than 13.12%. The method was applied to the determination of the azo dyes in water samples. Keywords: micro cloud point extraction, orange G, methyl orange, acid red 18, water analysis IntroductionThe importance of synthetic dyes in today industries can't be denied.1 Every year, thousands tons of such dyes are consumed in food, paper, leather, and textile industries.2,3 From these industries, large volumes of dyes are released to environment and find their way to water and soil. Environmental pollution with dyes can have dire effect on animal, plants, and human health. [4][5][6][7] One of the most important families of dyes is azo dyes that contain −N=N− bond in their structures.8 So far azo dyes have found many applications. Some azo dyes are quite harmful and poisonous, 9 and even those that are not toxic, like acid red 18, can be harmful if used in excess.10 Therefore the importance of their removal/decolorization 11-13 and their determinations [14][15][16][17] solvent (up to 3 mL). 44 To overcome these problems, in our previous work we introduced a micro-cloud point extraction (MCPE) technique. 45 While sustaining the merits of CPE, in MCPE water bath step is completely eliminated and the consumption of toxic organic solvents has been reduced from a few mL to a few ten μL. These make MCPE a fast, inexpensive, and green technique.In this paper MCPE was successfully applied for the determination of three azo dyes, orange G, methyl orange, and acid red 18 (Figure 1) in tap and wastewater samples. Acid red 18 (Panceau 4R) is a popular food color 46 and many methods have been proposed for its determination. 47,48 Methyl orange (acid orange 52 or gold orange) and orange G (orange gelb or wool orange) have many applications as textile dyeing stuff and staining agents in laboratories. These three dyes are of the most abundant used dyeing agents throughout the world and therefore can find their way to environmental sources as hazardous pollutions. 49,50 To our best knowledge this is the first report of determination of theses dyes with cloud point procedure. Non-ionic surfactant, triton X-114, was used as the extractant phase. Experimental InstrumentA Shimadzu UV-Vis spectrophotometer, UV-160 (Kyoto, Japan), equipped with two microcells (10 μL capacity, Star...

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Dispersive liquid–liquid microextraction based on solidification of floating organic droplet for the determination of triazine and triazoles in mineral water samples

Bolzan

Caldas

Guimarães

et al. 2016

J of Separation Science

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A simple, rapid, and sensitive method for the determination of atrazine, simazine, cyproconazole, tebuconazole, and epoxiconazole in mineral water employing the dispersive liquid-liquid microextraction with solidification of a floating organic drop with determination by liquid chromatography tandem mass spectrometry has been developed. A mixed solution of 250 μL 1-dodecanol and 1250 μL methanol was injected rapidly into 10 mL aqueous solution (pH 7.0) with 2% w/v NaCl. After centrifugation for 5 min at 2000 rpm, the organic solvent droplets floated on the surface of the aqueous solution and the floating solvent solidified. The method limits of detection were between 3.75 and 37.5 ng/L and limits of quantification were between 12.5 and 125 ng/L. The recoveries ranged from 70 to 118% for repeatability and between 76 and 95% for intermediate precision with a relative standard deviation from 2 to 18% for all compounds. Low matrix effect was observed. The proposed method can be successfully applied in routine analysis for determination of pesticide residues in mineral water samples, allowing for monitoring of triazine and triazoles at levels below the regulatory limits set by international and national legislations.

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Recent achievements in solidified floating organic drop microextraction

Cited by 94 publications

References 219 publications

Aplicação da microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante para determinação de 11-nor-9-carboxi-Δ9-tetraidrocanabinol em urina humana com derivação on-line no sistema de injeção cromatográfico

Aplicação da microextração líquido-líquido dispersiva com solidificação da gota orgânica flutuante para determinação de 11-nor-9-carboxi-Δ9-tetraidrocanabinol em urina humana com derivação on-line no sistema de injeção cromatográfico

Application of a Novel Micro-Cloud Point Extraction for Preconcentration and Spectrophotometric Determination of Azo Dyes

Dispersive liquid–liquid microextraction based on solidification of floating organic droplet for the determination of triazine and triazoles in mineral water samples

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