Receiver operating characteristic curves

Sedgwick, Philip

doi:10.1136/bmj.f2493

Cited by 162 publications

(201 citation statements)

References 2 publications

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“…In addition, a receiver operating characteristic (ROC) analysis of definite food allergy for sIgE values was performed and the null hypothesis of whether the area under the ROC curve was 0.5 was tested. 26 …”

Section: Discussionmentioning

confidence: 99%

Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements

et al. 2015

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BACKGROUND AND OBJECTIVES: Children with atopic dermatitis (AD) have a higher risk for development of food allergies. The objective of this study was to examine incidence of food allergy development in infants with AD and the predictive value of food-antigen-specific immunoglobulin E measurements.METHODS: This trial examined the long-term safety and efficacy of pimecrolimus cream 1% in .1000 infants (3-18 months) with mild-to-severe AD without a history of food allergy. Food allergy development was followed throughout a 36-month randomized double-blind phase followed by an open-label (OL) phase up to 33 months. Additionally, sIgE for cow's milk, egg white, peanut, wheat, seafood mix, and soybean was measured by ImmunoCAP at baseline, end of the double-blind phase, and end of OL phase.RESULTS: By the end of the OL phase, 15.9% of infants with AD developed at least 1 food allergy; allergy to peanut was most common (6.6%), followed by cow's milk (4.3%) and egg white (3.9%). Seafood, soybean, and wheat allergies were rare. Levels of sIgE for milk, egg, and peanut increased with severity of AD, as determined by Investigator's Global Assessment score. We assigned sIgE decision points for the 6 foods and tested their ability to predict definite food allergy in this population. Positive predictive values for published and newly developed sIgE decision points were low (,0.6 for all values tested). CONCLUSIONS:In a large cohort of infants at risk for development of food allergy, sIgE levels were not clinically useful for predicting food allergy development. WHAT'S KNOWN ON THIS SUBJECT:Food allergies are often thought to be a common trigger in atopic dermatitis (AD). Serum immunoglobulin E is frequently used to assess food sensitization and clinical allergy, but few studies have assessed it longitudinally in infants and children with AD. WHAT THIS STUDY ADDS:In a large infant population with mild to moderate AD, 15.9% of patients developed food allergy during the study. Serum immunoglobulin E decision points had low positive predictive values, indicating that they are of limited use in this population.

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Section: Discussionmentioning

confidence: 99%

Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements

et al. 2015

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“…Second, receiver operating characteristic (ROC) methods [13][14][15] were used to examine sensitivity and specificity for all possible breakpoints using a logistic regression model. The Youden index, 13 J = (sensitivity + specificity − 1), was calculated at each breakpoint.…”

Section: Discussionmentioning

confidence: 99%

22q13.2q13.32 genomic regions associated with severity of speech delay, developmental delay, and physical features in Phelan–McDermid syndrome

Sarasua

Dwivedi

Boccuto

et al. 2014

Genetics in Medicine

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“…Our study showed that using 0.00029 µg/ml of uKIM-1 as a cut-off value could exclude histological changes with 100% accuracy; whereas 42% of those with a uKIM-1 over this threshold were false positives (no histological change). Both sensitivity and specificity are relevant to assessment of the usefulness of a diagnostic method (Bewick et al, 2004). ROC analysis can guide selection of the optimal cut-point for decision-making.…”

Section: Discussionmentioning

confidence: 99%

“…ROC analysis can guide selection of the optimal cut-point for decision-making. To confirm a diagnosis, high specificity (> 95%) (Westin, 2001), or a high positive likelihood ratio is required (Bewick et al, 2004). Although a cut-off of over 0.00044 µg/ml showed a very high likelihood ratio (LR = 7), only 60% of animals that had kidney damage were detected.…”

Section: Discussionmentioning

confidence: 99%

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

Wunnapuk¹,

Liu²,

Gobé³

et al. 2014

Toxicology Letters

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Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup, leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The Roundup intoxication model involved oral administration of glyphosate to rats at dose levels of 250, 500, 1200 and 2500 mg/kg. Urinary and plasma biomarker patterns were investigated at 8, 24 and 48 hours after dosing.Biomarkers were quantified by absolute concentration; by normalising to urine creatinine; and by calculating the excretion rate. The diagnostic performances of each method in predicting of acute kidney injury were compared. By Receiver Operating Characteristic (ROC) analysis of the selected biomarkers, only urinary kidney injury molecule-1 (KIM-1) best predicted histological changes at 8 h (best cut-off point > 0.00029 µg/ml). Plasma creatinine performed better than other biomarkers at 24 h (best cut-off point > 0.21 mg/dl). Urinary KIM-1 was the best early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model.

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Receiver operating characteristic curves

Cited by 162 publications

References 2 publications

Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements

Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements

22q13.2q13.32 genomic regions associated with severity of speech delay, developmental delay, and physical features in Phelan–McDermid syndrome

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

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