Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma

Govindan, Balaji

doi:10.4103/0253-7184.192120

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Although they are the minority among human viruses, retroviruses were central to the emergence of mammals, thus also to humans, being pivotal components in placenta development ( Chuong, 2013 ). In addition, the human immunodeficiency virus (HIV), the main representative of the group, is one the main life-threatening pathogens, being responsible for immunosuppressive conditions, paving the way to numerous severe secondary infections such as tuberculosis, systemic mycosis, Kaposi sarcoma, among others ( Miceli et al, 2011 ; Godfrey-Faussett and Ayles, 2016 ; Govindan, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

An Anthropocentric View of the Virosphere-Host Relationship

et al. 2017

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For over a century, viruses have been known as the most abundant and diverse group of organisms on Earth, forming a virosphere. Based on extensive meta-analyses, we present, for the first time, a wide and complete overview of virus–host network, covering all known viral species. Our data indicate that most of known viral species, regardless of their genomic category, have an intriguingly narrow host range, infecting only 1 or 2 host species. Our data also show that the known virosphere has expanded based on viruses of human interest, related to economical, medical or biotechnological activities. In addition, we provide an overview of the distribution of viruses on different environments on Earth, based on meta-analyses of available metaviromic data, showing the contrasting ubiquity of head-tailed phages against the specificity of some viral groups in certain environments. Finally, we uncovered all human viral species, exploring their diversity and the most affected organic systems. The virus–host network presented here shows an anthropocentric view of the virology. It is therefore clear that a huge effort and change in perspective is necessary to see more than the tip of the iceberg when it comes to virology.

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Section: Resultsmentioning

confidence: 99%

An Anthropocentric View of the Virosphere-Host Relationship

et al. 2017

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“…Other investigations such as chest radiography (pleural effusions or hilar lymphadenopathy) and endoscopy are useful in identifying pulmonary and GI KS. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…Thalidomide, bevacizumab, oglufanide disodium, foscarnet, ganciclovir, and rapamycin are under trial. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

Kaposi's sarcoma: An interesting case report in a human immunodeficiency virus-positive heterosexual male

Samagani

Reddy

Raju

et al. 2022

Indian J Sex Transm Dis

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Kaposi's sarcoma (KS) is an angioproliferative neoplasm that affects skin and other organs. It is one of the acquired immune deficiency syndrome (AIDS)-defining conditions, which tends to occur at low CD4 count. It is the most common neoplasm among patients with AIDS in the Western population. It is rarely reported from India. We report the case of a 38-year-old human immunodeficiency virus-positive heterosexual male, with an unusual presentation of KS.

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“…Indeed, the Tat protein -with the help of its sequences of arginine and lysin -has properties which support not only the angiogenesis (by β-fibroblast growth factor and vascular endothelial growth factor A) but also the migration, proliferation, and expression of affected cells [7,8]. The elementary dermatological lesion in KS is an erythematous, angiomatous, and purplish macule which infiltrates gradually to become a papule, then a nodule, finally leading to the formation of broad plates resulting from the junction of budding cutaneous lesions; in addition, lymphedemas are seen more often [6,9]. Epidemic KS differs from other forms by its extensive distribution on the torso and the craniofacial area, frequent invasion into mucosal membranes (nasal, oral, and genital), and a very fast evolution leading to organ dysfunction and death [7,10].…”

mentioning

confidence: 99%

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon

Tounouga

Kouotou²,

Nansseu³

et al. 2018

Dermatology

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Background: The burden of Kaposi sarcoma (KS) is increasing fast among HIV-infected populations, but the disease remains desperately underexplored in Cameroon, where the burden of HIV is high. Methods: This is a retrospective cross-sectional study carried out over a period of 16 years (January 2001 to December 2016) at the HIV day care unit of the Central Hospital of Yaoundé, Cameroon. The diagnosis was based on clinical aspects and histological confirmation, and we used a preconstructed questionnaire for data collection through patients’ electronic and physical files. Results: Among 14,220 files reviewed, 316 cases of KS were identified, yielding a cumulative incidence of 2.2%. In the end, 266 patients (55% male) were included in this study. The patients’ age ranged from 17 to 72 years, with a mean of 37.8 ± 9.5 years. KS was the presenting manifestation of HIV in 89.8% of the cases. Cutaneous lesions occurred more often (81.6%), mainly located on the lower limbs (47.7%); mucous lesions were found in 15.8% of the patients, while 8 patients (3.0%) had associated visceral lesions. The lesions predominantly were lymphedemas (28.6%) and papulonodules (21.1%). At the diagnosis of KS, the median CD4 count was 175 cells/mm³ (interquartile range 80.5–288.5), and 150 patients (56.6%) had CD4 counts < 200 cells/mm³. Conclusions: KS is frequent among our HIV-infected patients; it seems to occur most often at a younger adult age and represents one of the presenting manifestations of HIV/AIDS in our context. It seems to equally affect men and women, occurring more often when CD4 counts are < 200 cells/mm³.

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Recapitulation of acquired immuno deficiency syndrome associated Kaposi's sarcoma

Cited by 8 publications

References 34 publications

An Anthropocentric View of the Virosphere-Host Relationship

An Anthropocentric View of the Virosphere-Host Relationship

Kaposi's sarcoma: An interesting case report in a human immunodeficiency virus-positive heterosexual male

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon

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