Recalcitrant giant orf recurrence after amputation: A case report and review of the literature

Saeidi, Vahide; Aminizade, Elahe; Kalantari, Yasamin; Goodarzi, Azadeh

doi:10.1002/ccr3.6209

Cited by 2 publications

(1 citation statement)

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“…Lastly, ORFV expresses vascular endothelial growth factor (VEGF encoded by ORFV132), which could be responsible for proliferative giant lesions reported in patients with immune deficiencies [ 48 ]. These lesions present as large, highly vascularized, tumor-like lesions, and may be mistaken for skin cancer and treated by surgical excision [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Human Orf with Immune-Mediated Reactions: A Systematic Review

et al. 2023

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Background: Orf is a highly contagious zoonosis caused by Orf virus (ORFV), which is endemic in sheep and goats worldwide. Human Orf is usually a self-limiting disease, but potential complications, including immune-mediated reactions, may occur. Methods: We included all articles regarding Orf-associated immunological complications published in peer-reviewed medical journals. We conducted a literature search of the United States National Library of Medicine, PubMed, MEDLINE, PubMed Central, PMC, and the Cochrane Controlled Trials. Results: A total of 16 articles and 44 patients were included, prevalently Caucasian (22, 95.7%) and female (22, 57.9%). The prevailing immunological reaction was erythema multiforme (26, 59.1%), followed by bullous pemphigoid (7, 15.9%). In most cases, the diagnosis was made on the basis of clinical and epidemiological history (29, 65.9%), while a biopsy of secondary lesions was performed in 15 patients (34.1%). A total of 12 (27.3%) patients received a local or systemic treatment for primary lesions. Surgical removal of primary lesion was described in two cases (4.5%). Orf-immune-mediated reactions were treated in 22 cases (50.0%), mostly with topical corticosteroids (12, 70.6%). Clinical improvement was reported for all cases. Conclusions: Orf-related immune reactions can have a varied clinical presentation, and it is important for clinicians to be aware of this in order to make a prompt diagnosis. The main highlight of our work is the presentation of complicated Orf from an infectious diseases specialist’s point of view. A better understanding of the disease and its complications is essential to achieve the correct management of cases.

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Section: Discussionmentioning

confidence: 99%