REC domain stabilizes the active heptamer of σ54-dependent transcription factor, FleR from Pseudomonas aeruginosa

Sahoo, Pankaj Kumar; Sheenu,; Jain, Deepti

doi:10.1016/j.isci.2023.108397

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2024

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“…We next moved to explore which environmental cues are transduced by FleR to repress T3SS gene expression. The crystal structure of the FleR REC domain was recently solved (PDB: 7W9H ), 38 and interestingly, a Ca 2+ ligand was found to interact with the REC domain instead of a Mg 2+ ion, which is highly conserved in the REC domain of response regulators for the catalysis of phosphorelay reactions. 39 Ca 2+ is an important host-related signal that triggers the acute-to-chronic virulence switch in P. aeruginosa , and repression of T3SS genes correlates with high Ca 2+ concentrations.…”

Section: Resultsmentioning

confidence: 99%