“…Tamura et al (2007) have also shown that, in the cerebral cortex, some of these DCX/Ng2 expressing cells may be proliferating or may have been recently generated. Two recent reports have also demonstrated that a, most likely local, population of Ng2+ precursors is able to differentiate into projection neurons in the adult murine piriform cortex (Guo et al, 2010); however, BrdU analyses suggest that these principal neurons have been generated from precursors that ceased to proliferate at least since the first postnatal month (Guo et al, 2010 andRivers et al, 2008). Our laboratory has also failed to find evidence of such dividing or recently generated cells in the adult rat paleocortex layer II, studying BrdU labeling and the expression of proteins commonly found in neuronal precursor cells of the adult CNS, such as nestin (Doetsch et al, 1997 andNacher et al, 2001b) or Pax6 (Hack et al, 2005.…”