Rebound effects of modern drugs: serious adverse events unknown by health professionals

Therapeutic use of the rebound effect of modern drugs: "New homeopathic medicines"

“…At the end of 2013, we published a review on the rebound effect of drugs in this journal, 13 showing the extent of the phenomenon and alerting health professionals about the serious consequences that this unknown adverse event can cause.…”

“…[14][15][16][17][18][19][20][21][22][23][24][25][26] Similarly, since the beginning of our studies, we have been suggesting the use of modern drugs in accordance with the principle of therapeutic similarity, proposing the use of drugs that cause adverse events similar to the manifestations of diseases in order to treat them homeopathically, using the rebound effect (paradoxical reaction) in a curative manner. 2,3,9,10,11,13,[27][28][29][30][31][32][33] In this study, we elaborate on this proposal in accordance with the assumptions of the homeopathic model and the fundamentals of modern pharmacology, describing existing research and a specific methodology for the therapeutic application of the rebound effect of modern drugs, suggesting the use of this practice in a complementary and adjuvant manner 34 in a myriad of diseases and syndromes. As such, we hope to contribute to medical knowledge, minimizing prejudice related to homeopathy and encouraging an expansion of the art of healing.…”

“…the principle of siMilarity in the light of Modern pharMacology [2][3][4][5][6][7][8][9][10][11][12][13] Building a bridge between the principle of similarity and modern scientific rationality, hundreds of studies de-scribed, in recent medical literature, the occurrence of secondary and opposite reactions of the organism after the primary actions of different drugs, confirming the homeopathic postulate. As mentioned previously, this secondary action or organism's reaction, which manifests itself automatically and instinctively in order to maintain the homeostasis of the system, is described by contemporary pharmacology and physiology as the rebound effect of the drugs, or paradoxical reaction of the organism, respectively.…”

“…Epidemiological studies show that this magnitude can cause severe and fatal events after the suspension of certain classes of drugs (antithrombotics, antidepressants, bronchodilators, anti-dyspeptics and immunomodulators, among others). [4][5][6][7][8][9][10][11][12][13] The rebound effect manifests itself at different intervals (hours to weeks) after the exhaustion of the biological effect (half-life) of the drug, and its duration is also variable. Despite the suspension or discontinuation of the drug being a prerequisite for the manifestation of the rebound effect, given that the primary action of the drug persists while the receptors are being stimulated (biological half-life), studies show that the rebound effect may also occur in the course of treatment due to therapeutic failure or the development of tolerance, tachyphylaxis or desensitization.…”

“…On the other hand, a slow and gradual reduction of doses (tapering) to prevent abrupt discontinuation can minimize the occurrence of the rebound effect. [2][3][4][5][6][7][8][9][10][11][12][13] In analogy to the proposal to be detailed below, reports in the literature describe the use of conventional drugs according to therapeutic similarity. Among these, we can cite the use of biphasic oral contraceptives to promote ovulation and rebound pregnancy in women with functional sterility and the use of central nervous system stimulants (methylphenidate) to treat attention deficit hyperactivity disorder (ADHD).…”