Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus

Bhoumik, Priyasma; Hughes, Austin L.

doi:10.3201/eid1611.100361

Cited by 5 publications

(3 citation statements)

References 14 publications

(19 reference statements)

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“…Some of them were shown to be under positive selection, such as those at positions 84, 222 and 374. Substitution N84S (also referred as N101S) has been highlighted as fixed amongst H1N1 (2009) strains compared to previous seasonal H1N1 influenza, where less than 1% of viruses had 84S [39] . Reversion to the “seasonal” residue S84N may be a sign of further adaptation to the human host.…”

Section: Discussionmentioning

confidence: 99%

Evolutionary Pathways of the Pandemic Influenza A (H1N1) 2009 in the UK

Galiano¹,

Agapow²,

Thompson³

et al. 2011

PLoS ONE

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The emergence of the influenza (H1N1) 2009 virus provided a unique opportunity to study the evolution of a pandemic virus following its introduction into the human population. Virological and clinical surveillance in the UK were comprehensive during the first and second waves of the pandemic in 2009, with extensive laboratory confirmation of infection allowing a detailed sampling of representative circulating viruses. We sequenced the complete coding region of the haemagglutinin (HA) segment of 685 H1N1 pandemic viruses selected without bias during two waves of pandemic in the UK (April-December 2009). Phylogenetic analysis showed that although temporal accumulation of amino acid changes was observed in the HA sequences, the overall diversity was less than that typically seen for seasonal influenza A H1N1 or H3N2. There was co-circulation of multiple variants as characterised by signature amino acid changes in the HA. A specific substitution (S203T) became predominant both in UK and global isolates. No antigenic drift occurred during 2009 as viruses with greater than four-fold reduction in their haemagglutination inhibition (HI) titre (“low reactors”) were detected in a low proportion (3%) and occurred sporadically. Although some limited antigenic divergence in viruses with four-fold reduction in HI titre might be related to the presence of 203T, additional studies are needed to test this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Evolutionary Pathways of the Pandemic Influenza A (H1N1) 2009 in the UK

Galiano¹,

Agapow²,

Thompson³

et al. 2011

PLoS ONE

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show abstract

“…HA is a major surface protein of influenza virus. Bhoumik et al (2010) explored the relations between recombination of ancient HA sequence and influenza virus HA sequence burst in 2009 [5], and found that HA protein in H1N1 virus was derived from NA protein or from more diverse proteins. The main protective immunity antigen protein to influenza virus induced by influenza virus; NA is one of the important fiber inlaid with virus particles with enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

Intelligent Computing Theories and Methodologies

2015

Lecture Notes in Computer Science

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“…There are several subtypes of IAVs based on the expression of surface proteins hemagglutinin (HA) and neuraminidase (NA) (Schulze et al, 2010 ). The IAV variants emerge as a result of reassortment between genes coding for various HA and NA genes (Bhoumik and Hughes, 2010 ). The emergence of these new IAVs subtypes could be linked to different clinical manifestations of the disease.…”

mentioning

confidence: 99%