Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets
Annika Graaf-Rau,
Kathrin Schmies,
Angele Breithaupt
et al.
Abstract:Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and antigenic drift are difficult to control in enzootically infected pig herds. Here, antibody-positive piglets from a herd enzootically infected with swIAV H1N2 (clade 1 A.3.3.2) were immunized using a homologous prime-boost vaccination strategy with novel live attenuated influenza virus (LAIV) based on a reassortment-incompetent bat influenza-swIAV chimera or a vesicu… Show more
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