Reassessment of ecotoxicities of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane in Japanese quail under the OECD draft new avian one-generation reproduction test guideline

Ueda, Hideo; Ebino, Koichi Y.; Fujie, Hideaki; Hayashi, Kôichi; Satoh, Minoru; Nakashima, Nobuaki; Chiba, Yuko; Harada, Takanori; Saka, Machiko; Koma, Yukiko; Nagata, Takuya; Odanaka, Yoshitsugu; Teramoto, Shoji

doi:10.1016/j.yrtph.2004.12.001

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…Table 1 summarises the statistical key data for eggshell breaking strength and thickness. Our findings were in line with guideline recommendations and published data for the Japanese quail (for example : Schlatterer et al, 1993;Mlynarčiková et al, 1995;Ueda et al, 2005;and Kamata et al, 2006aand Kamata et al, , 2006band Kamata et al, , 2009). The mean value of 0.193 mm as obtained for the whole test sample was at the lower limit of the recommended range for eggshell 236 Lars Niemann, Christine Gericke, Konstanze Grote and Ibrahim Chahoud (OECD, 1984).…”

Section: Introductionsupporting

confidence: 93%

Weak Correlation between Eggshell Thickness and Breaking Strength in Japanese Quail Suggests a need for Separate Assessment

Niemann

Gericke

Grote

et al. 2009

Avian Biology Research

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Based on experimental evidence obtained in Japanese quail (Coturnix coturnix japonica), concurrent determination of eggshell breaking strength in avian reproduction studies in addition to the routine parameter eggshell thickness is recommended. After transformation of breaking strength data, a regression analysis was performed on a large sample of eggs (n ¼ 815) from untreated hens. A need for concurrent assessment of both endpoints was substantiated by their poor correlation that became apparent by a rather low coefficient of determination (r 2 ) of less than 15%. It was further supported by strongly diverging results when sub-sets of eggs from smaller and more homogenous groups of quail in a number of one-generation studies were analysed for correlation of the two parameters.

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Section: Introductionsupporting

confidence: 93%

Weak Correlation between Eggshell Thickness and Breaking Strength in Japanese Quail Suggests a need for Separate Assessment

Niemann

Gericke

Grote

et al. 2009

Avian Biology Research

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“…2005). The sex difference in susceptibility to p,p′ ‐DDT has been observed in Japanese quail experiments, in which females were less susceptible than males because DDT and its metabolites were efficiently excreted into egg yolks (Ueda et al . 2005).…”

Section: Discussionmentioning

confidence: 96%

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Hojo¹,

Aoyama²,

Takahashi³

et al. 2006

Congenital Anomalies

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DDT, an organochlorine pesticide, has been cited as a representative chemical suspected of having endocrine disrupting effects. In this study, the potential endocrine disrupting activities of p,p'-DDT, a major component of DDT, were investigated in rats in a 2-generation reproduction toxicity study in accordance with the most current test guidelines of the Ministry of Agriculture, Forestry and Fisheries in Japan, Organization for Economic Cooperation and Development (OECD) and United States Environmental Protection Agency (USEPA) with some modifications and additions. p,p'-DDT was given to parental rats at dietary levels of 0, 5, 50 or 350 ppm. Systemic toxicities in the parental animals consisted of tremors and subsequent deaths (females only) and/or pathological alterations of the liver (both sexes of animals) of the 2 higher dose groups. Reproductive and postnatal developmental toxicities were not evident up to the highest dose level except for the decreased pup viability index on postnatal day 21 in the 350 ppm group. Changes in serum estradiol and progesterone levels and/or a delay in male sexual maturation were noted in the 2 higher dose groups in a dose-dependent fashion, suggesting alterations of endogenous endocrine functions. However, these changes never resulted in substantial reproductive disorders.

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“…The reproductive abnormalities caused by DDT were initially thought to be due to its estrogenicity. However, the apparent effects of the main component of DDT, p,p ′‐DDT, on embryonic development or the reproductive function of mature birds have not been verified [3,7]. Actually, the in vitro estrogenic activity of o,p ′‐DDT is substantially higher than p,p ′‐DDT and its metabolites [8]; experimental exposure of domestic chicken embryos on 3 or 4 d of incubation to o,p ′‐DDT was reported to result in eggshell thinning and abnormal development of the oviduct in adult females [9,10].…”

Section: Introductionmentioning

confidence: 99%

Reproductive and developmental effects of transovarian exposure to o,p′‐DDT in Japanese quails

Kamata¹,

Shiraishi²,

Takahashi³

et al. 2009

Enviro Toxic and Chemistry

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Avian species have the possible risk of embryonic exposure to persistent, lipophilic environmental contaminants, such as dichlorodiphenyltrichloroethane (DDT), by transfer of chemicals accumulated in mother birds to eggs. To model developmental and reproductive disorders of wild birds living in contaminated areas, we exposed Japanese quails in ovo to o,p'-DDT prior to incubation. A positive estrogenic substance diethylstilbestrol (DES; 1 and 10 ng/g of egg) and o,p'-DDT (1-100 microg/g of egg) were injected into the yolk before incubation. Treatment with o,p'-DDT (10 or 100 microg/g) but not with DES significantly reduced the hatchability of eggs. After sexual maturation, o,p'-DDT affected eggshell formation in female quails but had little influence on laying; high doses of o,p'-DDT significantly reduced eggshell strength, shell weight, and shell thickness, and several females treated with 100 microg o,p'-DDT/g laid eggs lacking shells. Diethylstilbestrol decreased egg production itself but had little effect on the eggshell. Both o,p'-DDT and DES caused dose-dependent shortening of the left oviduct and abnormal development of the right oviduct in females, while testis asymmetry was observed in males treated with a high dose of DES. In the uterus of the oviduct, the mRNAs for calcium-regulating factors osteopontin and calbindin D28K were reduced by both treatments, particularly that with o,p'-DDT. The results indicated that transovarian exposure to o,p'-DDT could bring about population declines in avian species through loss of fecundity caused by depression of hatchability and dysfunction of the reproductive tract.

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Reassessment of ecotoxicities of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane in Japanese quail under the OECD draft new avian one-generation reproduction test guideline

Cited by 7 publications

References 14 publications

Weak Correlation between Eggshell Thickness and Breaking Strength in Japanese Quail Suggests a need for Separate Assessment

Weak Correlation between Eggshell Thickness and Breaking Strength in Japanese Quail Suggests a need for Separate Assessment

Two‐generation reproduction toxicity study in rats with 1,1,1‐trichloro‐2,2‐bis(4‐chlorophenyl)ethane (p,p′‐DDT)

Reproductive and developmental effects of transovarian exposure to o,p′‐DDT in Japanese quails

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