Reassessment of changes in leucocyte and serum ascorbic acid after acute myocardial infarction.

Vallance, B D; Hume, Robert; Weyers, Elspeth

doi:10.1136/hrt.40.1.64

Cited by 29 publications

(6 citation statements)

References 7 publications

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“…A site of inflammation could therefore also constitute a drain of vitamin C from the whole organism. Leucocyte and plasma levels of ascorbate are significantly decreased in many different disorders [25], for example, the common cold [26,27], rheumatoid arthritis [28,29], and myocardial failure [30]. The mechanism proposed here could contribute to such changes.…”

Section: Discussionmentioning

confidence: 87%

Activated polymorphonuclear leucocytes consume vitamin C

1984

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Polymorphonuclear leucocytes (PMN) are known to produce superoxide and other oxygen derivatives upon activation as part of their microbicidal armory. Here we report that extracellular ascorbate is effectively oxidised by activated but not by resting human PMN in vitro. The oxidation of ascorbate is mainly caused by the superoxide that is generated by the activated ceils, as shown by its effective inhibition by superoxide dismutase. However, myeloperoxidase, which may generate hypochlorite, also contributes to a significant extent. Ascorbate reduces superoxide to peroxide, as indicated by measurements of the stoichiometry of ascorbate and oxygen consumption. These results support the notion that extracellular ascorbate may serve as an important physiological protecting agent against oxygen radical damage in inflammation.Ascorbate Superoxide Myeloperoxidase

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Section: Discussionmentioning

confidence: 87%

Activated polymorphonuclear leucocytes consume vitamin C

1984

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“…A continuous infusion of ascorbic acid would probably reduce the daily doses for substitution but leads to a spontaneous oxidation of ascorbic acid during infusion. Pharmacokinetics of intravenous ascorbic acid bolus substitution is commonly studied in healthy subjects [9,23] but Vallance et al [24] demonstrated that an intravenous dose of 1 g of ascorbic acid every 4 h led to normal ascorbic acid plasma values within 24 h in patients with acute myocardial infarction. Long et al [11] showed comparable effects with a substitution of 3 g/day in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Clearance of the Antioxidant Ascorbic Acid in Surgical Patients1

Rümelin

Humbert

Lühker

et al. 2005

Journal of Surgical Research

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“…Therefore, this dosage regime can be considered safe. It was previously shown that an intravenous substitution of 3 -6 g AA/day for up to 48 h [15,18] or 3 g AA for multiple weeks [19] produces no side effects.…”

Section: Discussionmentioning

confidence: 99%