Reassessment of ABO Blood Group, Sex, and Age on Laboratory Parameters Used to Diagnose von Willebrand Disorder

Background: Blood group and its relation to bleeding time (BT) and clotting time (CT) is important in conditions like epistaxis, thrombosis, and surgery. Earlier studies depicted O group having prolonged BT and CT. The aim of this study was to assess the relationship of BT and CT with ABO groups.Methods: This cross-sectional study was conducted in the department of physiology, Gauhati medical college. The study included 154 students. Blood grouping was determined with the standard antiserum; BT and CT were estimated by the duke method and slide method, respectively. Blood group and its relation to BT, CT were analyzed by Chi-square analysis.Results: Blood group O (42.2%) was predominant in both genders followed by B (31.8%), A (21%), AB (4.5%). CT was found to be more than 6 minutes in group O (31.57%) followed by group AB (26.31%), A and B (21.05%). The difference was statistically significant (p = 0.02). BT was found to be more than 4 minutes in group O (82.35%) followed by A (11.76%), B (5.88%), and AB (0%). That was statistically significant (p = 0.01). CT was more than 6 minutes in 57.89% in females as compared to 42.10% in males, variation was statistically significant (p = 0.01). BT was more than 4 minutes in 58.82% females as compared to 41.17% in males. The variation was statistically significant (p = 0.03).Conclusions: In present study blood group O was more common followed by B, A, and AB. CT and BT were prolonged in O group. BT and CT were more in females than males.

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“…5,6 Von Willebrand factor is a large glycoprotein produced by endothelial cells and megakaryocytes. Its major function is haemostasis.…”

Section: Introductionmentioning

confidence: 99%

“…13 It is also suggested by authors that blood group O is associated with lower expression of Von Willebrand factor causing a relative bleeding tendency but other workers could not find out any association between the level of Von Willebrand factor and bleeding time. [14][15][16] Aims and objectives of this study was to find out - …”

Section: Introductionmentioning

confidence: 99%

Blood group and its relationship with bleeding time and clotting time- an observational study among the 1st MBBS students of Gauhati medical college, Guwahati

2017

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“…Genetically defined ABO blood group influences FVIII:Coagulant (FVIII:C) levels such that both FVIII:C and von Willebrand factor (VWF) levels are significantly lower in individuals with blood group O as compared to non-O bloodgroup [41] .Blood group O blood individuals are at greater risk for bleeding and may be at lower risk for venous thrombosis. High levels of VWF and FVIII:C are associated with thrombosis risk.…”

Section: Fviii:c Abo Blood Group and Dvtmentioning

confidence: 99%

“…In acute DVT patients (21,41,73,74 MECS may also be used for symptomaticrelief of swollen acute DVT legs combined with low-molecular weight heparins (LMWH) followed by vitamin K antogonists (VKA) or novel oral anticoagulants (NOACs). Pneumatic compression therapy has been proved to be effective, but is probably only realistic in post-operative circumstances, and it has shown to be effective in for example elective knee or hip replacement [21,41,74].…”

Section: Management Of Dvt In the Primary Care And Hospital Settingmentioning

confidence: 99%

“…A ratio between 2.0. and 3.0 should be achieved for the most adequate anticoagulation, and the lowest risk of bleeding. Heparin can be discontinued after 5 to7 days, as long as the INR is stable and 2.0 or greater [3,41]. Idiopathic venous thromboembolism is generally treated for 6 months, but anticoagulation may be for life for those with continuing risk [75].…”

Section: Standard Anticoagulant Treatment Of Dvtmentioning

confidence: 99%

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Complete Compression Ultrsonography, Clinical Score, Underlying Risk

Michiels¹,

Strijkers²,

Michiels³

et al. 2015

J Hematol Thrombo Dis

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Primary Superficial Thrombophlebitis (SVT)The incidence of superficial thrombophlebitis (SVT) is approximately 1.6 per 1000 persons per year. Several studies have confirmed the association of SVT and VTE. In a systematic review of patients with SVT, 6% to 44% of cases was associated with deep vein thrombosis (DVT), 20% to 33% with asymptomatic pulmonary embolism (PE) and 2% to 13% with symptomatic PE. Assessment of risk factor in the MEGA study a history of clinical SVT was associated with a 6.3-fold risk of DVT and a 3.9 risk of PE. In a study of 263 SVT patients, 30 (11.4%) developed DVT. Among 125 patients with SVT located in the great saphena vein, 16.8% developed DVT. Out of 138 patients with isolated SVT below the knee only 4.5% developed DVT. In a lower limb ultrasound study in 2646 patients 36 (9.3%) of the patients had combined DVT and PTS. These data indicate that primary SVT should be considered an integral part of DVT. The presence of inherited hypercoagulability or venous thrombophilia in both SVT and DVT strongly supports a similar etiology and pathphysiology. In… patients with primar SVT hereditary protein C and s deficiency was detected in 6.45% in the absence of DVT and in 62.5% in SVT patient who had developed DVT. In our experience hereditary heterozygous antithrombin defiencoiency (AT) is associated with a high risk on DVT and PE not preceded by SVT. Congenital protein C (PC) or protein S (PS) deficiency in 27 DVT patients (15 males, 12 females) in 6 unrelated Dutch families had a history of SVT 19 cases (70%) as the hall mark of congenital PC/PS deficiency. The prevalence of FV Leiden, FII A20210 mutation, and PC or PS deficiency in 63 evaluated SVT patients was 16%, 906% and 10% respectively (total 36%) as compared to 3%, 2.4% and 0.6% in 537 controls. The incidence of inherited thrombophilic risk factors in patients with a first DVT is high (31%) as compared to 5 to 6% in the general population (Table 1). In 1668 patients with a first DVT in the Leiden prospective study the incidence of congenital thrombophilia was 25%. In this study 417 (25%) of 1668 patients with a first DVT were on oral contraceptives below the age of 50 years. In 400 Czech young women with VTE on oral contraceptives (distal DVT 58%, proximal DVT 16%, PE 5%, thrombosis at unusual sites 20%) inherited thrombophilia was diagnosed in 195 (49%): FV Leiden 35% FIIA20210 mutation 5%,AT,PC PS deficiency 3.6% and antiphopholipid syndrome 5.3%. We conclude that thrombophilia screening is manadatory in SVT and DVT patients and in women on contraceptive pills in particular for the education of clinicians abling them to much better counsel their SVT and DVT patients and their relatives. AbstractSuperficial vein thrombosis is an integral part of venous thromboembolism (VTE) together with deep vein thrombosis (DVT) and pulmonary embolism (PE). The incidence of SVT is 1.6 per 1000 persons per year. The incidence of DVT is about 1.0 per 1000 persons per year in the general population, 1.8 per 1000 persons per year at age 65 to 69 years...

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