Rearrangement in rDNA-bearing chromosomes in cell lines from neoplastic cells

Henderson, A.; Megraw-Ripley, S.

doi:10.1016/0165-4608(82)90016-4

Cited by 16 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using cytological hybridization in situ to investigate the location and relocation of ribosomal DNA (rDNA) sites. Hender son and Megraw '-Ripley (1982) looked at 16 ceil lines from a variety of tumors, principally leukemias and lymphomas. Thirteen of these 16 lines showed changes involving the NORs of acrocentric chromosomes, al terations which could be divided into three groups: those demonstrating an excess or reduced number of genes at known loci, those showing intercalated rDNA in Robertsonian translocations or other rear rangements, and those with a distinct rearrangement of a portion of the rDNA to a terminal position on the long arm of an acrocentric chromosome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ectopic nucleolus organizer regions (NORs) in human testicular tumors

DeLozier-Blanchet¹,

Walt

Engel³

1986

Cytogenet Genome Res

View full text Add to dashboard Cite

Investigation of nucleolus organizer regions (NORs) in hematopoietic malignancies has indicated that the distribution and rearrangement of these regions may be more important in malignant tissues than is their number. In one of the few studies thus far reported on NORs in human solid tumors, we describe here Ag-NORs in a group of human testicular germ-cell tumors and the corresponding patients. Four of seven malignancies demonstrated consistent ectopic NORs; explanations could include chromosomal rearrangement (insertion?) or derepression of preexisting inactive NORs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…such NOR modifications have only rarely been described (Hubbell and Hsu. 1977;Henderson and Mcgraw-Ripley, 1982).…”

mentioning

confidence: 99%