Reappraising the role of dopamine in adolescent risk-taking behavior

França, Thiago F. A.; Pompéia, Sabine

doi:10.1016/j.neubiorev.2023.105085

Cited by 6 publications

(4 citation statements)

References 85 publications

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“…Risky decision making in general, and performance in the RDT specifically, are strongly regulated by dopamine signaling ( Orsini et al, 2015 ; Piantadosi et al, 2021 ; França and Pompeia, 2023 ). Previous work with the RDT shows that higher levels of risk taking are associated with both higher levels of evoked dopamine release in nucleus accumbens ( Freels et al, 2020 ) and lower expression of D2 receptor mRNA in striatum ( Mitchell et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of reproductive experience on cost-benefit decision making in female rats

Faraji,

Viera-Resto,

Setlow

et al. 2024

Front. Behav. Neurosci.

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Many individuals undergo mating and/or other aspects of reproductive experience at some point in their lives, and pregnancy and childbirth in particular are associated with alterations in the prevalence of several psychiatric disorders. Research in rodents shows that maternal experience affects spatial learning and other aspects of hippocampal function. In contrast, there has been little work in animal models concerning how reproductive experience affects cost–benefit decision making, despite the relevance of this aspect of cognition for psychiatric disorders. To begin to address this issue, reproductively experienced (RE) and reproductively naïve (RN) female Long-Evans rats were tested across multiple tasks that assess different forms of cost–benefit decision making. In a risky decision-making task, in which rats chose between a small, safe food reward and a large food reward accompanied by variable probabilities of punishment, RE females chose the large risky reward significantly more frequently than RN females (greater risk taking). In an intertemporal choice task, in which rats chose between a small, immediate food reward and a large food reward delivered after a variable delay period, RE females chose the large reward less frequently than RN females. Together, these results show distinct effects of reproductive experience on different forms of cost–benefit decision making in female rats, and highlight reproductive status as a variable that could influence aspects of cognition relevant for psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Effects of reproductive experience on cost-benefit decision making in female rats

Faraji,

Viera-Resto,

Setlow

et al. 2024

Front. Behav. Neurosci.

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show abstract

“…Risky decision making in general, and performance in the RDT specifically, are strongly regulated by dopamine signaling (França & Pompeia, 2023; Orsini et al, 2015; Piantadosi et al, 2021). Previous work with the RDT shows that higher levels of risk taking are associated with both higher levels of evoked dopamine release in nucleus accumbens (Freels et al, 2020) and lower expression of D2 receptor mRNA in striatum (Mitchell et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of Reproductive Experience on Cost-Benefit Decision Making in Females and Males

Faraji,

Viera-Resto,

Setlow

et al. 2023

Preprint

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Almost all individuals undergo reproductive and/or parenting experience at some point in their lives, and pregnancy and childbirth in particular are associated with alterations in the prevalence of several psychiatric disorders. Research in rodents shows that maternal experience affects spatial learning and other aspects of hippocampal function. In contrast, there has been little work in animal models concerning how reproductive experience affects cost-benefit decision making, despite the relevance of this aspect of cognition for psychiatric disorders. To begin to address this issue, reproductively experienced (RE) and reproductively naïve (RN) female and male Long-Evans rats were tested across multiple tasks that assess different forms of cost-benefit decision making. In a risky decision-making task, in which rats chose between a small, safe food reward and a large food reward accompanied by variable probabilities of punishment, RE and RN males did not differ, whereas RE females chose the large risky reward significantly more frequently than RN females (greater risk taking). In an intertemporal choice task, in which rats chose between a small, immediate food reward and a large food reward delivered after a variable delay period, RE males chose the large reward more frequently than RN males, whereas RE females chose the large reward less frequently than RN females. Together, these results show distinct effects of reproductive experience on different forms of cost-benefit decision making in rats of both sexes, and highlight reproductive status as a variable that could influence aspects of cognition relevant for psychiatric disorders.

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“…For example, a recent review of the role of dopamine in these processes (Franca & Pompeia, 2023) argues that rather than a simple competition between "hot" subcortical reward systems and "cool" prefrontal cognitive control systems, dopamine actually contributes to both reward seeking and cognitive control systems and promotes goaldirected effort (rather than just promoting reward seeking). Franca and Pompeia (2023) note that decisions about "risky" behaviors involve more than reward and control systems but also include processes of evaluating options, appraising risk, anticipating outcomes, and executing actions, and that to varying extents, dopamine is involved in all of these components. This model places provides a somewhat broader view of adolescent decision making with greater emphasis on adolescents as tolerating ambiguity, exploring, and adaptively learning from their experiences.…”

Section: The Significance Of Adolescence As a Developmental Periodmentioning

confidence: 99%

Understanding alcohol use and alcohol use disorders from a developmental psychopathology perspective: Research advances, challenges, and future directions

Chassin,

Sher

2024

Dev Psychopathol

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As part of the special issue of Development and Psychopathology honoring the remarkable contributions of Dr Dante Cicchetti, the current paper attempts to describe the recent contributions that a developmental psychopathology perspective has made in understanding the development of alcohol use and alcohol-related problems over the lifespan. The paper also identifies some of the future challenges and research directions. Because the scope of this task far exceeds the confines of a journal length article this paper does not attempt a comprehensive review. Rather, it builds on an earlier review and commentary that was published in Development and Psychopathology in 2013, with a similar goal.)Building on that work and updating its conclusions and suggestions for future directions, the current paper emphasizes findings from the research areas that were identified for further study in 2013 and the findings that have been published since that time.

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Reappraising the role of dopamine in adolescent risk-taking behavior

Cited by 6 publications

References 85 publications

Effects of reproductive experience on cost-benefit decision making in female rats

Effects of reproductive experience on cost-benefit decision making in female rats

Effects of Reproductive Experience on Cost-Benefit Decision Making in Females and Males

Understanding alcohol use and alcohol use disorders from a developmental psychopathology perspective: Research advances, challenges, and future directions

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