Reappraising 21 years of the WHI study: Putting the findings in context for clinical practice

Stute, Petra; Marsden, Jo; Salih, N.; Cagnacci, Angelo

doi:10.1016/j.maturitas.2023.04.271

Cited by 5 publications

(2 citation statements)

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“…In fact, the enrolled women were asymptomatic, on average older than 60 years old, and frequently more than 10 years after the onset of menopause. These results struck the medical community, causing widespread distrust in HRT, with a dramatic drop in its prescription in the following years [14].…”

Section: Introductionmentioning

confidence: 99%

“…The most prominent medical societies published numerous guidelines on the proper use and prescription of HRT, focusing mainly on adequate patient selection and route of administration. Apparently, this effort was not enough to settle the confusion among both health professionals and patients on the indications for HRT: a diffuse distrust and many uncertainties appear to persist among physicians [4,14,17].…”

Section: Introductionmentioning

confidence: 99%

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Menopausal Hormone Therapy, an Ever-Present Topic: A Pilot Survey about Women’s Experience and Medical Doctors’ Approach

Aquino,

Stampini,

Osella

et al. 2024

Medicina

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Background and Objective: Menopause can be associated with many clinical manifestations: vasomotor symptoms, urogenital problems, and additional psychological disturbances, such as anxiety, mood changes, and sleep alterations. The prolonged lack of hormones also increases the risk of long-term consequences. Hormone Replacement Treatment (HRT) in menopause consists of the administration of estrogen, alone or associated to progesterone, to relieve these uncomfortable disturbances and to prevent the onset of other pathologic conditions. The aim of this study is to examine the prevalence of HRT use in a sample of menopausal women and their experience with menopause and HRT. This study also investigates the knowledge of general practitioners (GPs) and gynecologists about HRT and its prescription. Materials and Methods: We conducted a cross-sectional population survey on 126 women of 50–59 years in an industrial city in the North of Italy, Vercelli (Novara), in Eastern Piedmont. We also presented a questionnaire on the topic to 54 medical doctors (GPs and gynecologists) of the same area. Results: The prevalence of HRT use in our sample was 11.9%. In total, a good percentage of the users affirmed to be satisfied with HRT. Additionally, a minority of women reported being ideally against the use of replacement hormones, were advised against using HRT by doctors, and did not use it because of the fear of side effects. We found a positive association between patient education, health care attitude, and HRT usage. A significant number of women knew about HRT from the media, and most of them were not informed by a health professional. Despite this, the interviewed doctors considered their knowledge about HRT as ‘good’ and would recommend HRT: only 5.6% would not prescribe it. Conclusions: Our results highlight the need for information about HRT among patients and health professionals, along with the need for more effective communication, evaluation, and suggestion of treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%