Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

Mikami, Yoshiki; Kiyokawa, Takako; Sasajima, Yuko; Teramoto, Norihiro; Wakasa, T.; Wakasa, Kenichi; Hata, Sakae

doi:10.1111/j.1365-2559.2008.03202.x

Cited by 70 publications

(81 citation statements)

References 22 publications

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“…In some cases, this has been interpreted as representing transtubal spread from the neoplasm within the cervix 1. It is also possible that in some cases this represents mucinous metaplasia of the fallopian tube epithelium since this has been described in Peutz Jeghers syndrome without adenoma malignum 34 35. The second interesting feature is that chromogranin positive neuroendocrine cells were present within the neoplastic glands in the well differentiated component; argyrophilic cells have been described previously in adenoma malignum 1…”

Section: Discussionmentioning

confidence: 79%

Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome

et al. 2010

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An unusual cervical adenocarcinoma is reported in a 50-year-old woman with a history of Peutz Jeghers syndrome. The carcinoma contained two morphologically distinct and spatially separate components, one comprising typical well differentiated adenoma malignum and the other a moderately differentiated neoplasm, in keeping with gastric type adenocarcinoma. Both components were positive for HIK1083 and MUC6 and negative for p16, and did not contain human papillomavirus. It is believed that such a composite tumour has not been described in the literature. It is believed that the component of gastric type adenocarcinoma arose through a process of dedifferentiation within adenoma malignum and we provide circumstantial molecular evidence in support of the interpretation that both components may be clonally related in that they displayed an extra copy of chromosome 7. This raises the possibility of a relationship between these two uncommon types of cervical adenocarcinoma, both of which are thought to exhibit gastric differentiation.

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Section: Discussionmentioning

confidence: 79%

Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome

et al. 2010

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“…These authors also found a molecular-genetic link between LEGH and cervical mucinous glandular malignancies, including MDA and MAC, and suggested that some LEGH lesions are precursors of MDA and/or MAC lesions. A close association between synchronous mucinous metaplasia and neoplasms of the female genital tract (SMMN-FGT) and LEGH/pyloric gland metaplasia (PGM) was verified by Mikami et al [24], and Ichimura et al [16] consider MDA to be a malignant conversion of endocervical glands now expressing gastric mucin. They also suggest that the expression level of p53 may be an indicator of the local progression of MDA.…”

Section: Discussion and Reviewmentioning

confidence: 91%

Minimal deviation adenocarcinoma of the uterine cervix

Jiang

Gui

et al. 2010

Intl J Gynecology & Obste

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“…This is clearly seen in STK-11 gene mutations, especially in patients with Peutz–Jeghers syndrome,45 where EMM occurs as a spectrum of histological changes ranging from metaplasia to carcinoma, involving synchronously cervix, corpus, fallopian tube and ovary. Multifocality, however, can also occur sporadically 41 43…”

Section: Epithelial Emcsmentioning

confidence: 99%

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

2010

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Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. EMCs vary from reactive, degenerative lesions to those able to associate with malignancy or those having a preneoplastic potential. The most common types of EMCs are ciliated tubal metaplasia (CTM) and mucinous metaplasia (MM), which occur in simple and complex glands, and possibly these architectural changes hold the same prognostic significance as they do in hyperplastic endometrioid lesions. Immunohistochemically, CTM is positive for LhS28, bcl-2, PAX2 and p16

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Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

Abstract: There is a close association between SMMN-FGT and LEGH/PGM. Microinvasion and positive peritoneal cytology may not have an influence on outcome.

Cited by 70 publications

References 22 publications

Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome

Composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with Peutz Jeghers syndrome

Minimal deviation adenocarcinoma of the uterine cervix

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation

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