Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases

Stafford, Paul; Norris, Brent

doi:10.1016/s0020-1383(10)70014-0

Cited by 249 publications

(138 citation statements)

References 27 publications

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“…Large bone defects (>5 cm) may be treated with bone segment transport or free vascularized bone transfer (49), as the use of an autologous bone graft alone is not recommended because of the risk of graft resorption despite good soft tissue coverage (50). The vascularised fibula autograft (51) and the Ilizarov method (52)(53)(54) are the most commonly used treatment methods for larger bone defects; however, complications are common and the process can be laborious and painful for the patient as she/he may be required to use external fixation systems for up to one and half years (49,(55)(56).…”

Section: Bone Grafting and Bone Substitutes In The Last 4 000 Yearsmentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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Section: Bone Grafting and Bone Substitutes In The Last 4 000 Yearsmentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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“…This technique has been shown to be effective both in animal models and in clinical practice for tibial and femoral defects. 13,14 The membrane surrounding the spacer has been shown to be well vascularized and has cells expressing angiogenic and osteogenic factors, including bone morphogenetic protein-2 (BMP-2), which is hypothesized to contribute to the healing of the defect. 15 While the Masquelet technique has been shown to be effective in the treatment of long bone defects, it is still dependent on the use of autologous or allograft tissue.…”

mentioning

confidence: 99%

Effect of Cell Origin and Timing of Delivery for Stem Cell-Based Bone Tissue Engineering Using Biologically Functionalized Hydrogels

Dosier

Uhrig

Willett

et al. 2015

Tissue Engineering Part A

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Despite progress in bone tissue engineering, the healing of critically sized diaphyseal defects remains a clinical challenge. A stem cell-based approach is an attractive alternative to current treatment techniques. The objective of this study was to examine the ability of adult stem cells to enhance bone formation when co-delivered with the osteoinductive factor bone morphogenetic protein-2 (BMP-2) in a biologically functionalized hydrogel. First, adipose and bone marrow-derived mesenchymal stem cells (ADSCs and BMMSCs) were screened for their potential to form bone when delivered in an RGD functionalized alginate hydrogel using a subcutaneous implant model. BMMSCs co-delivered with BMP-2 produced significantly more mineralized tissue compared with either ADSCs co-delivered with BMP-2 or acellular hydrogels containing BMP-2. Next, the ability of BMMSCs to heal a critically sized diaphyseal defect with a nonhealing dose of BMP-2 was tested using the alginate hydrogel as an injectable cell carrier. The effect of timing of therapeutic delivery on bone regeneration was also tested in the diaphyseal model. A 7 day delayed injection of the hydrogel into the defect site resulted in less mineralized tissue formation than immediate delivery of the hydrogel. By 12 weeks, BMMSC-loaded hydrogels produced significantly more bone than acellular constructs regardless of immediate or delayed treatment. For immediate delivery, bridging of defects treated with BMMSC-loaded hydrogels occurred at a rate of 75% compared with a 33% bridging rate for acellular-treated defects. No bridging was observed in any of the delayed delivery samples for any of the groups. Therefore, for this cell-based bone tissue engineering approach, immediate delivery of constructs leads to an overall enhanced healing response compared with delayed delivery techniques. Further, these studies demonstrate that co-delivery of adult stem cells, specifically BMMSCs, with BMP-2 enhances bone regeneration in a critically sized femoral segmental defect compared with acellular hydrogels containing BMP-2.

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“…Se usó injerto aútologo en 19 (95%) pacientes, siendo la fuente de injerto la cresta iliaca en 17 casos y en 2 casos se usó injerto autólogo obtenido mediante sistema de fresado y aspirado del canal femoral (Sistema RIA) (26). En tres casos se complementó con injerto heterólogo.…”

Section: Resultsunclassified

“…La técnica de Masquelet se puede aplicar tanto en miembros superiores como inferiores (16,18,26,31).…”

Section: A B Cunclassified

Reconstrucción de defectos óseos segmentarios postraumáticos mediante técnica de inducción de membrana

et al. 2015

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Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases

Cited by 249 publications

References 27 publications

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Effect of Cell Origin and Timing of Delivery for Stem Cell-Based Bone Tissue Engineering Using Biologically Functionalized Hydrogels

Reconstrucción de defectos óseos segmentarios postraumáticos mediante técnica de inducción de membrana

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