Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations

Giagka, Vasiliki; Serdijn, Wouter A.

doi:10.1186/s42234-018-0010-y

Cited by 47 publications

(32 citation statements)

References 101 publications

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“…[ 331 ] More recently they have found application in bioelectronic medicine, where the electrical modulation of nerve activity is used to treat pathological conditions. [ 332–334 ] The anatomical structure of the peripheral nervous system is a challenge for bioelectronic interfaces. Peripheral nerves undergo relatively huge mechanical strain as a result of limb motion, [ 335 ] with underlying nerve fibers sheathed in several fatty layers that permit fascicles (bundles of axons) to slide past each other.…”

Section: In Vivo Applicationsmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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Conjugated polymers exhibit interesting material and optoelectronic properties that make them well‐suited to the development of biointerfaces. Their biologically relevant mechanical characteristics, ability to be chemically modified, and mixed electronic and ionic charge transport are captured within the diverse field of organic bioelectronics. Conjugated polymers are used in a wide range of device architectures, and cell and tissue scaffolds. These devices enable biosensing of many biomolecules, such as metabolites, nucleic acids, and more. Devices can be used to both stimulate and sense the behavior of cells and tissues. Similarly, tissue interfaces permit interaction with complex organs, aiding both fundamental biological understanding and providing new opportunities for stimulating regenerative behaviors and bioelectronic based therapeutics. Applications of these materials are broad, and much continues to be uncovered about their fundamental properties. This report covers the current understanding of the fundamentals of conjugated polymer biointerfaces and their interactions with biomolecules, cells, and tissues in the human body. An overview of current materials and devices is presented, along with highlighted major in vivo and in vitro applications. Finally, open research questions and opportunities are discussed.

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Section: In Vivo Applicationsmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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“…These studies use methodological advances in material science, bioengineering, neuroscience, data analytics, computer modeling and mathematics, immunology, molecular biology, and other disciplines ( Fig. 3; Bettinger 2018; Giagka and Serdijn 2018;Guduru et al 2018;Kovatchev 2018;Qing et al 2018;Sanjuan-Alberte et al 2018;Silverman et al 2018;Pavlov and Tracey 2019). Applying multidisciplinary approaches has been instrumental in discovering new molecular mechanisms of CNS and peripheral neural regulation, and identifying new therapeutic targets (Fig.…”

Section: Bioelectronic Medicine: An Expanding Fieldmentioning

confidence: 99%

Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment

Pavlov

Chavan

Tracey

2019

Cold Spring Harb Perspect Med

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Bioelectronic medicine is an evolving field in which new insights into the regulatory role of the nervous system and new developments in bioelectronic technology result in novel approaches in disease diagnosis and treatment. Studies on the immunoregulatory function of the vagus nerve and the inflammatory reflex have a specific place in bioelectronic medicine. These studies recently led to clinical trials with bioelectronic vagus nerve stimulation in inflammatory diseases and other conditions. Here, we outline key findings from this preclinical and clinical research. We also point to other aspects and pillars of interdisciplinary research and technological developments in bioelectronic medicine.

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“…For this reason, a great deal of research has been dedicated to replacing the bulky titanium cases with flexible polymers and thin-film coating layers [1], [2]. Recently, these efforts have been further endorsed by the new field of bioelectronic medicine, in which small, flexible, and lightweight implants are needed for targeting the delicate nerve structures within the body [3]. In previous work, we have shown an active electrode array for epidural spinal cord stimulation in which silicone rubber was used for the packaging of the miniature integrated circuits (ICs) [4].…”

Section: A Chip Integrity Monitor For Evaluating Long-term Encapsulatmentioning

confidence: 99%

A Chip Integrity Monitor for Evaluating Long-term Encapsulation Performance Within Active Flexible Implants

Akgun

Nanbakhsh

Giagka

et al. 2019

2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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One key obstacle in employing silicon integrated circuits in flexible implants is ensuring a long-term operation of the chip within the wet corrosive environment of the body. For this reason, throughout the years, various biocompatible insulating materials have been proposed, yet, evaluating their long-term encapsulation performance on representative silicon samples still remains to be the main challenge. For this aim, in this work, a sensitive platform is introduced that can track the integrity of the chip against water and ion ingress. This platform is developed to be used for long-term monitoring of chip integrity and study of encapsulation layers in wet environments. The platform comprises a sensing array and a measurement engine and operates by tracking the changes in the inter-layer dielectric resistance within the chip. The proposed system uses a novel charge/discharge-based time-mode resistance sensor that can be implemented using simple yet highly robust circuitry. The sensor array is implemented together with the measurement engine in a standard 0.18 µm 6-metal CMOS process. For chip validation, dry and wet measurements in saline are presented in this paper.

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Realizing flexible bioelectronic medicines for accessing the peripheral nerves – technology considerations

Abstract: Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (

Cited by 47 publications

References 101 publications

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment

A Chip Integrity Monitor for Evaluating Long-term Encapsulation Performance Within Active Flexible Implants

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