Realization of a flow injection analysis in PCB technology

Gaßmann, Stefan; Ibendorf, Ingo; Pagel, Lienhard

doi:10.1016/j.sna.2006.04.009

Cited by 27 publications

(28 citation statements)

References 2 publications

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“…83 Similarly, Nguyen et al 84 demonstrated a peristaltic micropump, integrating piezoelectric discs on the PCB pump chamber. The same advantageous technology was implemented later 85 for the fabrication of a sophisticated microflow injection analysis system comprising a stack of 4 structured PCB layers, on which two micropumps and a reaction coil microchannel were integrated into the same substrate together with an optical detector (LED and photodiode), its control circuit, and the pump control circuit (Fig. 5B).…”

Section: Technology Overview and Demonstrated Prototypesmentioning

confidence: 99%

“…not commonly used in the PCB industry, requiring the introduction of new materials and modified processes for upscaling. An interesting exception to the above works is the work of the Rostock group 81,82,85,110 that implements a multilayer standard PCB technology without additional process steps, as well as of those of a few other groups (work to be described below) implementing only materials with which the PCB industry is quite familiar, i.e. rigid PCB, flexible PI, photosensitive PI-based dry films, and other laminates.…”

Section: Technology Overview and Demonstrated Prototypesmentioning

confidence: 99%

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The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

2017

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Commercialization of lab-on-a-chip devices is currently the "holy grail" within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines are increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies in the lack of an established commercial manufacturing technology. The lab-on-printed circuit board (lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well established all around the world, with standardized fabrication facilities and processes, but commercially exploited currently only for electronics. Owing to these characteristics, complex μTASs integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in the literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTASs, which could in turn trigger the projected exponential market growth of μTASs, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.

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Section: Technology Overview and Demonstrated Prototypesmentioning

confidence: 99%

Section: Technology Overview and Demonstrated Prototypesmentioning

confidence: 99%

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

2017

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“…The main advantages of this technology are low cost and low clean room requirements [13,14]. The measured self-resonance frequencies of micro coils indicate that they have a promising application in the low-field NMR device.…”

Section: Introductionmentioning

confidence: 97%

Low-field NMR micro coils based on printed circuit board technology

Zhou

et al. 2014

Sci. China Technol. Sci.

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Radiofrequency coil is one of the most important components for a nuclear magnetic resonance (NMR) instrument. In this article, some planar micro coils with an inner diameter of 2 mm and number of turns that varied from 1 to 11 were investigated based on the printed circuit board (PCB) technology. The electrical characterization of micro coils show that self-resonant frequencies are larger than 200 MHz. Then, an NMR measurement platform with a static magnetic field of 0.66 T was constructed and the signal to noise ratio (SNR) values of the NMR were analyzed. It was found that the SNR is optimal when the turn number of the micro coils is six and the excitation time of a 90° pulse is 0.8 s. Finally, we used the micro coil with six turns to study the transverse relaxation rate of copper sulfate pentahydrate aqueous solution with different concentrations. It was found that the transverse relaxation rate is proportional to the solution concentration. Results from the micro coil were verified by measurements using a Bruker Minispec MQ60.printed circuit board, planar micro coil, low-field nuclear magnetic resonance, signal to noise ratio, transverse relaxation rate Citation:Wu W P, Lu R S, Zhou X L, et al. Low-field NMR micro coils based on printed circuit board technology.

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“…Lateral flow assays [ 25 , 26 , 27 , 28 , 29 ] and smartphone-based [ 30 ] colorimetric [ 31 , 32 , 33 ] and electrochemical [ 34 , 35 , 36 ] PoC devices are only few, indicative examples of the vast work been done so far towards PoC testing devices that can reduce detection time, increase detection accuracy and ultimately reduce overall cost. Lab-on-PCB (LoPCB) is an alternative approach to PoC diagnostic systems that could reduce the costs associated with complex detection architectures [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. By developing effective diagnostic systems utilising the already matured PCB technology and manufactured using standard materials and processes could further lower the cost of the PCB-based biosensing platforms, in line with ASSURED criteria, without sacrificing detection accuracy [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection

Evans

Papadimitriou

Vasilakis

et al. 2018

Sensors

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Point of Care (PoC) diagnostics have been the subject of considerable research over the last few decades driven by the pressure to detect diseases quickly and effectively and reduce healthcare costs. Herein, we demonstrate a novel, fully integrated, microfluidic amperometric enzyme-linked immunosorbent assay (ELISA) prototype using a commercial interferon gamma release assay (IGRA) as a model antibody binding system. Microfluidic assay chemistry was engineered to take place on Au-plated electrodes within an assay cell on a printed circuit board (PCB)-based biosensor system. The assay cell is linked to an electrochemical reporter cell comprising microfluidic architecture, Au working and counter electrodes and a Ag/AgCl reference electrode, all manufactured exclusively via standard commercial PCB fabrication processes. Assay chemistry has been optimised for microfluidic diffusion kinetics to function under continual flow. We characterised the electrode integrity of the developed platforms with reference to biological sampling and buffer composition and subsequently we demonstrated concentration-dependent measurements of H2O2 depletion as resolved by existing FDA-validated ELISA kits. Finally, we validated the assay technology in both buffer and serum and demonstrate limits of detection comparable to high-end commercial systems with the addition of full microfluidic assay architecture capable of returning diagnostic analyses in approximately eight minutes.

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Realization of a flow injection analysis in PCB technology

Cited by 27 publications

References 2 publications

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

Low-field NMR micro coils based on printed circuit board technology

A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection

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