Real-World Safety and Efficacy of Fluid-Filled Dual Intragastric Balloon for Weight Loss

Endoscopic bariatric and metabolic therapies: Another tool for the management of diabetes and obesity

“…17 There were no reported deaths, device migrations, or intestinal obstructions with the balloon. 17 The dual balloon system initially exhibited a higher rate of gastric ulceration (35%), but a minor design change midway through the trial decreased this rate to 10%. 16 Of note, a recent warning from the FDA in June 2018 reported a total of 12 deaths worldwide from IGBs, seven of which occurred in patients in the US (https://www.fda.…”

“…A recently published retrospective study on the efficacy of the ReShape balloon reported a mean (±SD) TBWL of 11.4 ± 6.7% . There were no reported deaths, device migrations, or intestinal obstructions with the balloon . The dual balloon system initially exhibited a higher rate of gastric ulceration (35%), but a minor design change midway through the trial decreased this rate to 10% …”

“…The REDUCE Pivotal Trial found 25.1% excess weight loss (EWL) for patients at 6 months . A recently published retrospective study on the efficacy of the ReShape balloon reported a mean (±SD) TBWL of 11.4 ± 6.7% . There were no reported deaths, device migrations, or intestinal obstructions with the balloon .…”

Gastric space-occupying devices for management of obesity and metabolic disease

“…In a retrospective series of 101 patients, the mean %total weight loss (%TWL) and %EWL were 11.4 § 6.7 and 29.9 § 18.2 at 6 months, and 14.7 § 11.8 and 36.4 § 28.1 at 12 months. Fifty-five percent achieved at least 25% EWL, and 60% achieved at least 10% TWL at 6 months [40].…”

Are We Moving in the Right Direction by Altering Gastric Motility for Weight Loss?

“…3 Endoscopic bariatric therapies, such as intragastric balloons and endoscopic sleeve gastroplasty, induce clinically significant weight loss. [4][5][6][7] However, they have not matched the degree of weight loss nor the weight independent benefits observed with bariatric surgery. 2,8 This may be the result of physicians and industry focusing efforts on developing endoscopic procedures that imitate the restrictive aspects of bariatric surgery rather than mimicking the changes in metabolic signaling.…”