Real-world efficacy of deep TMS for obsessive-compulsive disorder: Post-marketing data collected from twenty-two clinical sites

Roth, Yiftach; Tendler, Aron; Arıkan, Mehmet Kemal; Vidrine, Ryan; Kent, David M.; Muir, Owen; MacMillan, Carlene; Casuto, Leah; Grammer, Geoffrey; Sauvé, William; Tolin, Kellie; Harvey, Steven; Borst, Misty; Rifkin, Robert M.; Sheth, Manish; Cornejo, Brandon J.; Rodriguez, Raul; Shakir, Saad; Porter, Taylor; Kim, Deborah; Peterson, Brent M.; Swofford, Julia; Roe, Brendan; Sinclair, Rebecca; Harmelech, Tal; Zangen, Abraham

doi:10.1016/j.jpsychires.2020.11.009

Cited by 40 publications

(27 citation statements)

References 25 publications

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“…The finding of 10 sessions of active stimulation having a larger mean effect than one session is consistent with previous research that suggests consecutive sessions of NIBS, such as rTMS, are more effective in inducing longer-lasting plastic changes within cortical regions such as the M1 81 . It is also consistent with clinical protocols for NIBS treatments in neuropsychiatric disorders where rTMS is applied over a number of sessions, for example, depression (30 sessions over 4-6 weeks) 82 and obsessive-compulsive disorder (29 sessions) 83 . Nonetheless, optimal parameters for both NIBS protocols and session quantity and timing for dystonia are yet to be established.…”

Section: Number Of Non-invasive Brain Stimulation Sessionssupporting

confidence: 71%

Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis

Morrison-Ham

Clark

Ellis

et al. 2021

Preprint

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BackgroundDeep brain stimulation is a highly effective treatment of dystonia, but is invasive and associated with risks, such as intraoperative bleeding and infections. Previous research has used non-invasive brain stimulation (NIBS) in an attempt to alleviate symptoms of dystonia. The results of these studies, however, have been variable, leaving efficacy unclear. This study aimed to evaluate the effects of NIBS on symptoms of dystonia and determine whether methodological characteristics are associated with variability in effect size.MethodsEmbase and MEDLINE Complete databases were searched for articles using any type of NIBS as an intervention in dystonia patients, with changes in dystonia symptoms the primary outcome of interest.ResultsMeta-analysis of 26 studies demonstrated a small effect size for NIBS in reducing symptoms of dystonia (random-effects Hedges’ g = 0.21, p = .002). Differences in the type of NIBS, type of dystonia, and brain region stimulated had a significant effect on dystonia symptoms. Meta-regression revealed that 10 sessions of active stimulation, and the application of concurrent motor training programs resulted in significantly larger mean effect sizes.ConclusionNIBS has yielded small improvements to dystonic symptoms, but effect sizes depended on methodological characteristics, with more sessions of stimulation producing a larger response. Future research should further investigate the application of NIBS parallel to motor training, in addition to providing a greater quantity of sessions, to help define optimal parameters for NIBS protocols in dystonia.RegistrationPROSPERO 2020, CRD42020175944.

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Section: Number Of Non-invasive Brain Stimulation Sessionssupporting

confidence: 71%

Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis

Morrison-Ham

Clark

Ellis

et al. 2021

Preprint

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“…Overall, the literature suggests that PAS can be effective, but also that a high level of cooperation between the spontaneous brain activity and stimulation-induced activity is necessary for reliable and effective neuromodulation. The overall idea, namely to administer a neuromodulation treatment during or right after specific states of brain activity, is also important for rTMS treatments: in the Food and Drug Administration (FDA) approved rTMS protocols for smoking cessation or to treat obsessive-compulsive disorders (OCD), subjects are required to observe smoking or OCD symptoms are provoked right before administrating the rTMS treatment, to "activate the relevant neuronal circuits" (FDA, 2018;Roth et al, 2020).…”

Section: Paired Associative Stimulation (Pas)mentioning

confidence: 99%

Neurostimulation for Stroke Rehabilitation

et al. 2021

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Neurological injuries such as strokes can lead to important loss in motor function. Thanks to neuronal plasticity, some of the lost functionality may be recovered over time. However, the recovery process is often slow and incomplete, despite the most effective conventional rehabilitation therapies. As we improve our understanding of the rules governing activity-dependent plasticity, neuromodulation interventions are being developed to harness neural plasticity to achieve faster and more complete recovery. Here, we review the principles underlying stimulation-driven plasticity as well as the most commonly used stimulation techniques and approaches. We argue that increased spatiotemporal precision is an important factor to improve the efficacy of neurostimulation and drive a more useful neuronal reorganization. Consequently, closed-loop systems and optogenetic stimulation hold theoretical promise as interventions to promote brain repair after stroke.

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“…The response rate compared to sham treatment was significantly higher for up to one month. Recently it has been demonstrated that in realworld clinical practice, dTMS with H7 over mPFC-dACC was beneficial for the majority of OCD patients (98/135, 73%) with the onset of sustained improvement usually occurring after 20 sessions [10].…”

mentioning

confidence: 99%

Electrical field measurements and simulations of the H7 and D-B80 coils: Non-equivalence of the TMS coils for obsessive compulsive disorder

Tzirini

Roth

Harmelech³

et al. 2021

Brain Stimulation

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Real-world efficacy of deep TMS for obsessive-compulsive disorder: Post-marketing data collected from twenty-two clinical sites

Cited by 40 publications

References 25 publications

Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis

Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis

Neurostimulation for Stroke Rehabilitation

Electrical field measurements and simulations of the H7 and D-B80 coils: Non-equivalence of the TMS coils for obsessive compulsive disorder

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