Real-world effectiveness of daily teriparatide in Japanese patients with osteoporosis at high risk for fracture: final results from the 24-month Japan Fracture Observational Study (JFOS)

Soen, Satoshi; Fujiwara, Saeko; Takayanagi, Ryoichi; Kajimoto, Kenta; Tsujimoto, Mika; Kimura, Shuichi; Sato, Masayo; Krege, John H.; Enomoto, Hiroyuki

doi:10.1080/03007995.2017.1354826

Cited by 31 publications

(29 citation statements)

References 44 publications

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“…This study shows that the fracture rate decreases with the increase of the time of administration of teriparatide. This is similar to our results [27][28][29][30][31][32][33][34][35][36][37][38][39][40]. There are three systematic reviews and meta-analysis of the impact of anti-osteoporotic drug adherence on prognosis [17][18][19].…”

Section: Discussionsupporting

confidence: 91%

Adherence to Teriparatide Treatment and Risk of Fracture: A Systematic Review and Meta-Analysis

Chen

Guo

et al. 2019

Horm Metab Res

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To conduct a retrospective systematic review and meta-analysis of studies investigating the fracture risk among adherence versus non-adherence patients to treatment for osteoporosis. Cohort studies involving adherence to specifically Teriparatide treatment and the risk of fracture, published from inception to June 10 2019, were identified through PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and Scopus database of Systematic Reviews. Five eligible cohort studies were included for analysis. Overall, adherence, compared with nonadherence, had a significant 28% reduction in the risk of all fractures, an 49% reduction in the risk of hip fracture and an 26% reduction in the risk of non-vertebral fracture. Subgroup analyses showed that treatment compliant North American patients had a lower incidence of fracture than treatment compliant Asian patients. The effect size associated with adherence showed no difference with non-adherence when the analysis was limited to a small sample size (<10 000 patients). The findings of this retrospective review indicate that high compliance of Teriparatide treatment result in a decreased risk of fracture, particularly in North American treatment adherence, compared with Asian treatment adherence. Improvement of treatment adherence in patients with osteoporosis should be considered through various means in clinical practice.

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Section: Discussionsupporting

confidence: 91%

Adherence to Teriparatide Treatment and Risk of Fracture: A Systematic Review and Meta-Analysis

Chen

Guo

et al. 2019

Horm Metab Res

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“…Two explanations have been given for this association between muscle mass and bone parameters. There is known muscle-bone cross-talk and muscle-derived myokines exert anabolic effects on bone [ 3 , 16 ]. Thus, in one explanation, an increased muscle mass would lead to a higher secretion of myokines, which can have greater effects on bone density [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Current treatments for osteoporosis are not entirely effective [ 3 ] and simply lead to an increase in health care expenditure. Thus, effective osteoporosis prevention protocols and guidelines aimed at increasing and maintaining bone mass need to be developed.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Physical Fitness, Body Composition, and Nutrition Are Associated with Bone Status in University Students

et al. 2018

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Understanding the modifiable factors that improve and maximize peak bone mass at an early age is necessary to design more effective intervention programs to prevent osteoporosis. To identify these modifiable factors, we analyzed the relationship of physical activity (PA), physical fitness, body composition, and dietary intake with bone stiffness index (SI), measured by quantitative ultrasonometry in young university students (18–21 years). Moderate-to-vigorous PA (MVPA) was the strongest predictor of SI (β = 0.184; p = 0.035). SI was most closely related with very vigorous PA in males (β = 0.288; p = 0.040) and with the number of steps/day in females (β = 0.319; p = 0.002). An association between thigh muscle and SI was consistent in both sexes (β = 0.328; p < 0.001). Additionally, extension maximal force was a bone SI predictor factor in females (β = 0.263; p = 0.016) independent of thigh muscle perimeter. Calcium intake was the only nutrition parameter that had a positive relationship with SI (R = 0.217; p = 0.022). However, it was not included as a predictor for SI in our regression models. This study identifies predictors of bone status in each sex and indicates that muscle and bone interrelate with PA and fitness in young adults.

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“…The Japan Fracture Observational Study (JFOS) was a prospective observational study that assessed the effectiveness of once-daily teriparatide in Japanese patients with osteoporosis treated in a real-world clinical setting. The baseline patient characteristics, preliminary 12-month findings [ 17 ], and final 24-month findings for JFOS have been published [ 18 ]. The main aim of this secondary analysis of the original study was to assess the effect of patient-support program enrollment on adherence to once-daily teriparatide.…”

Section: Introductionmentioning

confidence: 99%

Effect of a patient-support program on once-daily teriparatide adherence and persistence in the Japan Fracture Observational Study (JFOS)

et al. 2018

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Summary Japanese patients with osteoporosis prescribed once-daily teriparatide for 24 months could enroll in a patient-support program designed to aid adherence and persistence. Patients enrolled in the program had higher adherence and persistence rates than those who did not enroll, highlighting the value of patient-support programs for improving adherence and persistence. Objective To assess the effect of a patient-support program on once-daily teriparatide adherence and persistence of patients who did and did not enroll. Methods In the 24-month Japan Fracture Observational Study, patients with osteoporosis prescribed teriparatide 20 μg/day (N = 1996) could freely enroll in a patient-support program (call center support, monthly calendar, certificates of recognition). Outcome measures were medication adherence (investigator assessed) and persistence (first date of teriparatide use to last date of use or study end). Multivariate logistic models were applied for adherence, and Kaplan-Meier survival curve for persistence. Results Overall, mean ± standard deviation (SD) age was 76.9 ± 7.9 years, and the proportion of female patients was 90.1%. Program enrollment status was 39.6% yes (n = 790), 22.9% no (n = 458), and 37.5% unknown (n = 748). In the analysis sample (1248 patients), adherence (> 75%) to teriparatide was more likely for patients enrolled in the support program (54.2 vs. 48.3%; adjusted odds ratio 1.44 [95% confidence intervals 1.04-2.00], p = 0.030). Good to very good (> 75%) adherence was also associated with smoking (negative association) and previous osteoporosis therapy (marginal positive association). Persistence rates were greater for patients enrolled in the support program than not enrolled (12 months 77.2 vs. 69.6%; 24 months 63.2 vs. 54.8%). Conclusions Once-daily teriparatide adherence and persistence rates were higher among patients who enrolled in a patientsupport program than among those who did not, highlighting the value of patient-support programs for improving adherence and persistence.

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Real-world effectiveness of daily teriparatide in Japanese patients with osteoporosis at high risk for fracture: final results from the 24-month Japan Fracture Observational Study (JFOS)

Abstract: JFOS demonstrated effectiveness of teriparatide 20 μg/day to reduce the risk of clinical fractures in Japanese patients in a real-world setting.

Cited by 31 publications

References 44 publications

Adherence to Teriparatide Treatment and Risk of Fracture: A Systematic Review and Meta-Analysis

Adherence to Teriparatide Treatment and Risk of Fracture: A Systematic Review and Meta-Analysis

Physical Activity, Physical Fitness, Body Composition, and Nutrition Are Associated with Bone Status in University Students

Effect of a patient-support program on once-daily teriparatide adherence and persistence in the Japan Fracture Observational Study (JFOS)

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