Real-world data on initial treatment strategies for older adult patients with endometrial cancer in Japan

Yunokawa, Mayu; Sasada, Shinsuke; Takehara, Yae; Takahashi, Katsumi; Shimoi, Tatsunori; Yonemori, Kan; Ishikawa, Masatoshi; Kato, Tomoyasu; Tamura, Kenji

doi:10.1007/s00280-019-03938-8

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…We considered that a lower median BMI was related to regional factors. In a previous report from Japan, the BMI was 22.5–24.1, which is similar to the present study 30 , 31 .…”

Section: Discussionsupporting

confidence: 93%

Prognosis and adjuvant chemotherapy for patients with positive peritoneal cytology in stage IA endometrial cancer

Kanno

Yunokawa

Nakabayashi

et al. 2022

Sci Rep

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This study evaluated the influence of positive peritoneal cytology (PPC) on the prognosis of patients with stage IA endometrial cancer, and the usefulness of adjuvant chemotherapy in their treatment. We retrospectively analyzed the data of patients with stage IA endometrial cancer admitted in our hospital between 2005 and 2015. Among 989 patients who underwent peritoneal cytology, 135 (13.7%) had PPC. Multivariate analysis extracted several independent risk factors for recurrence in stage IA patients, including those with PPC. Adjuvant chemotherapy did not cause a significant difference in the 5-year relapse-free survival rate in patients with PPC (p = 0.78). Similarly, the 5-year recurrence-free survival rate with or without chemotherapy was not different among type II cancer patients (p = 0.11). However, the baseline risk of 5-year relapse-free survival without chemotherapy in patients with PPC and type II was very low (66.7%). While PPC was an independent risk factor for recurrence in stage IA endometrial cancer, adjuvant chemotherapy did not influence the survival rate in patients with PPC. While it is controversial whether adjuvant chemotherapy should be administered in stage IA uterine cancer with only PPC as a prognostic factor, it should be considered for early-stage patients who have multiple risk factors for recurrence.

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“…We considered that a lower median BMI was related to regional factors. In a previous report from Japan, the BMI was 22.5–24.1, which is similar to the present study 30 , 31 .…”

Section: Discussionsupporting

confidence: 93%

Prognosis and adjuvant chemotherapy for patients with positive peritoneal cytology in stage IA endometrial cancer

Kanno

Yunokawa

Nakabayashi

et al. 2022

Sci Rep

Self Cite

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“…The perfusion fraction f of the tissue represents the proportion of the stroma at different vascular levels to the diseased tissue, which is correlated to the microstructure of the tissue. Tamura et al [ 13 ] considered that the f value of non-invasive breast cancer is significantly higher than that of invasive breast cancer. The present study revealed that the minimum value, mean, kurtosis, the 10th percentile and the 50th percentile of malignant lesions are significantly lower than those of benign breast lesions.…”

Section: Discussionmentioning

confidence: 99%

The role of histogram analysis in diffusion-weighted imaging in the differential diagnosis of benign and malignant breast lesions

Jin

Zhang

Cheng

et al. 2020

BMC Med Inform Decis Mak

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Background The present study aims to investigate the role of histogram analysis of intravoxel incoherent motion (IVIM) in the differential diagnosis of benign and malignant breast lesions. Methods The magnetic resonance imaging and clinical data of 55 patients (63 lesions) were retrospectively analyzed. The multi-b-valued diffusion-weighted imaging image was processed using the MADC software to obtain the gray-scaled maps of apparent diffusion coefficient (ADC)-slow, ADC-fast and f. The MaZda software was used to extract the histogram metrics of these maps. Combined with the conventional sequence images, the region of interest (ROI) was manually drawn along the edge of the lesion at the maximum level of the gray-scale image, and the difference of the data was analyzed between the benign and malignant breast lesions. Results There were 29 patients with 37 benign lesions, which included 23 fibroadenomas, 6 adenosis, 1 breast cysts, 4 intraductal papillomas, and 3 inflammations of breast. Furthermore, 26 malignant lesions in 26 patients, which included 20 non-specific invasive ductal carcinomas, 5 intraductal carcinomas and 1 patient with squamous cell carcinoma. The ADC-slow (mean and the 50th percentile) and f (minimum, mean, kurtosis, the 10th percentile and 50th percentile) of these malignant breast lesions were significantly lower than those of benign lesions (P < 0.05), while ADC-fast (kurtosis) and f (variance, skewness) of these malignant breast lesions were significantly higher than those of benign lesions (P < 0.05). Conclusion The histogram analysis of ADC-slow (mean and the 50th percentile), ADC-fast (kurtosis) and f (minimum, mean, kurtosis, the 10th percentile and 50th percentile. Variance, skewness) can provide a more objective and accurate basis for the differential diagnosis of benign and malignant breast lesions.

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Real-world database analysis of the characteristics and treatment patterns of patients with endometrial cancer in Japan

Akada

Koyama

Miura

et al. 2021

Current Medical Research and Opinion

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Real-world data on initial treatment strategies for older adult patients with endometrial cancer in Japan

Cited by 4 publications

References 26 publications

Prognosis and adjuvant chemotherapy for patients with positive peritoneal cytology in stage IA endometrial cancer

Prognosis and adjuvant chemotherapy for patients with positive peritoneal cytology in stage IA endometrial cancer

The role of histogram analysis in diffusion-weighted imaging in the differential diagnosis of benign and malignant breast lesions

Real-world database analysis of the characteristics and treatment patterns of patients with endometrial cancer in Japan

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