Real-world assessment of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) nasopharyngeal swab testing in a region with a high burden of coronavirus disease 2019 (COVID-19)

Sangal, Rohit B.; Peaper, David R.; Rothenberg, Craig; Fadlallah, Hasan; Mobolaji-Lawal, Motunrayo; Landry, Marie L.; Sussman, L. Scott; Ulrich, Andrew; Venkatesh, Arjun K.

doi:10.1017/ice.2021.153

Infect. Control Hosp. Epidemiol.

2021

DOI: 10.1017/ice.2021.153

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Real-world assessment of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) nasopharyngeal swab testing in a region with a high burden of coronavirus disease 2019 (COVID-19)

Rohit B. Sangal

David R. Peaper

Craig Rothenberg

et al.

Abstract: Concerns persist regarding possible false negative results that may compromise COVID-19 containment. While obtaining a true false negative rate is infeasible, using real world observation these data suggest a possible false negative rate to be approximately 2.3%. Use of a sensitive, amplified RNA platform should reassure healthcare systems.

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Cited by 2 publications

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Clinical validation of 3D-printed swabs in adults and children for SARS-CoV-2 detection

Sanchez-Sandoval,

Sánchez-Pérez,

García-García

et al. 2023

Biology Methods and Protocols

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Throughout the entire COVID-19 pandemic, there were disruptions in the supply chain of test materials around the world, primarily in poor and middle-income countries. The use of 3D-prints is an alternative to address swab supply shortages. In this study, the feasibility of the clinical use of 3D-printed swabs for oropharyngeal and nasopharyngeal sampling for the detection of SARS-CoV-2 infection was evaluated. For that purpose, paired samples with the 3D-printed and the control swabs were taken from 42 adult patients and 10 pediatric patients, and the results obtained in the detection of SARS-CoV-2 by RT-qPCR were compared. Additionally, in those cases where the result was positive for SARS-CoV-2, the viral load was calculated by means of a mathematical algorithm proposed by us. For both adults and children, satisfactory results were obtained in the detection of SARS-CoV-2 by RT-qPCR; no significant differences were found in the Cq values between the 3D-printed swab samples and the control samples. Furthermore, we corroborated that the 3D-printed swabs caused less discomfort and pain at the time of sampling. In conclusion, this study shows the feasibility of routinely using 3D-printed swabs for both adults and children. In this way it is possible to maintain local and cheaper consumption, along with fewer distribution difficulties.

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Clinical validation of 3D-printed swabs in adults and children for SARS-CoV-2 detection

Sanchez-Sandoval,

Sánchez-Pérez,

García-García

et al. 2023

Biology Methods and Protocols

View full text Add to dashboard Cite

show abstract

Salivary Specimen in COVID-19 Testing for Dental Settings: A Meta-Analysis Comparing Saliva, Nasopharyngeal and Serum Specimens

Soman,

Hawzah,

Alsomali

et al. 2024

Ann Dent Spec

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Real-world assessment of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) nasopharyngeal swab testing in a region with a high burden of coronavirus disease 2019 (COVID-19)

Cited by 2 publications

References 9 publications

Clinical validation of 3D-printed swabs in adults and children for SARS-CoV-2 detection

Clinical validation of 3D-printed swabs in adults and children for SARS-CoV-2 detection

Salivary Specimen in COVID-19 Testing for Dental Settings: A Meta-Analysis Comparing Saliva, Nasopharyngeal and Serum Specimens

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