Real-World Analysis of the Aging Effects on Visual Field Reliability Indices in Central 10-2 Tests

Abstract

We investigated the influence of aging on the reliability indices of visual field (VF) testing using a large dataset of central 10-2 program tests, including 6674 VF tests, which consisted of 1782 eyes of 1094 Japanese subjects (the mean age ± standard deviation was 66.6 ± 14.1 years). All of the combinations for each parameter, except for the pairs between age and fixation losses (FLs) or false positives (FPs) and between pattern standard deviation (PSD) and FPs, had significant correlations (p < 0.0001). Among the reliability indices, the false negatives (FNs) had the strongest correlation against age (the correlation coefficient was ρ = 0.21). Each reliability index changes differently with aging. The FLs were the highest in the first 10 s and remained constant after 20 s. The FNs remained constant for 60 s and rose steeply after 70 s. The FPs reached their highest value in 10 s and remained constant after 40 s. In mixed-effect regression analyses in 40-year-old or older subjects, older age was significantly associated with higher FNs (p < 0.0001) but not with FLs (p = 0.9014) and FPs (p = 0.9267). Compared to central 30-2 VF testing, central 10-2 VF tests were associated with smaller FLs (p < 0.0001) and FPs (p < 0.0001). In central 10-2 testing, age-related deterioration was seen in FNs but not in FLs and FPs. Choosing the 10-2 program over the 30-2 program can be effective in reducing the FL, especially in older cases with severe VF loss. This study highlighted the relationships between age and each reliability index in central 10-2 VF testing.

Roles of Cognitive Function on Visual Field Reliability Indices among Glaucoma Patients

“…The effects of SERE observed in univariate analyses (Tables 2 and 3) disappeared in multivariable analysis (Table 6), and this can be attributed to covariate effects related to aging. Prior studies have reported the impact of aging on VF sensitivity [16,20,21], which aligns with our observation of a significant association between CI and MD (Table 2). In multivariable analysis, we also noted higher FL, FN, and FP in females compared to males (Table 6).…”

“…Previously, we reported that aging is associated with decreased reliability in VF testing using a large VF dataset in a real-world setting [20,21]. Each five-point decline in the MoCA score was associated with an increase of 0.23 dB in the prediction error of MD.…”

Microperimetry Characteristics of Regions With a Truly Nonresponding Location: Implications for Atrophic Age-Related Macular Degeneration

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“…Another factor—and perhaps the most important factor—that can affect the results of visual field tests is aging. Although higher false negatives were significantly associated with older age, older age was not found to be related to fixation losses or false positives [ 1 ]. In our current study, when examining severe visual field defects, especially in older patients, similar to other studies, we found that choosing the 10-2 program versus the 30-2 program was effective in reducing the fixation losses.…”